Literature DB >> 35091693

Loss of TRP53 reduces but does not overcome dependency of lymphoma cells on MCL-1.

Andreas Strasser1,2, Gemma L Kelly3,4, Brandon J Aubrey5,6,7, Margs S Brennan5,6,8, Sarah T Diepstraten5,6, Zilu Wang5,6, Catherine Chang5, Marco J Herold5,6.   

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Year:  2022        PMID： 35091693      PMCID： PMC9090779          DOI： 10.1038/s41418-022-00946-9

Source DB:  PubMed          Journal:  Cell Death Differ        ISSN： 1350-9047            Impact factor:   12.067


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  7 in total

1.  The combination of reduced MCL-1 and standard chemotherapeutics is tolerable in mice.

Authors:  Kerstin Brinkmann; Stephanie Grabow; Craig D Hyland; Charis E Teh; Warren S Alexander; Marco J Herold; Andreas Strasser
Journal:  Cell Death Differ       Date:  2017-08-11       Impact factor: 15.828

2.  The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models.

Authors:  András Kotschy; Zoltán Szlavik; James Murray; James Davidson; Ana Leticia Maragno; Gaëtane Le Toumelin-Braizat; Maïa Chanrion; Gemma L Kelly; Jia-Nan Gong; Donia M Moujalled; Alain Bruno; Márton Csekei; Attila Paczal; Zoltán B Szabo; Szabolcs Sipos; Gábor Radics; Agnes Proszenyak; Balázs Balint; Levente Ondi; Gábor Blasko; Alan Robertson; Allan Surgenor; Pawel Dokurno; Ijen Chen; Natalia Matassova; Julia Smith; Christopher Pedder; Christopher Graham; Aurélie Studeny; Gaëlle Lysiak-Auvity; Anne-Marie Girard; Fabienne Gravé; David Segal; Chris D Riffkin; Giovanna Pomilio; Laura C A Galbraith; Brandon J Aubrey; Margs S Brennan; Marco J Herold; Catherine Chang; Ghislaine Guasconi; Nicolas Cauquil; Fabien Melchiore; Nolwen Guigal-Stephan; Brian Lockhart; Frédéric Colland; John A Hickman; Andrew W Roberts; David C S Huang; Andrew H Wei; Andreas Strasser; Guillaume Lessene; Olivier Geneste
Journal:  Nature       Date:  2016-10-19       Impact factor: 49.962

3.  p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa.

Authors:  Andreas Villunger; Ewa M Michalak; Leigh Coultas; Franziska Müllauer; Gunther Böck; Michael J Ausserlechner; Jerry M Adams; Andreas Strasser
Journal:  Science       Date:  2003-09-18       Impact factor: 47.728

4.  Loss of a Single Mcl-1 Allele Inhibits MYC-Driven Lymphomagenesis by Sensitizing Pro-B Cells to Apoptosis.

Authors:  Stephanie Grabow; Alex R D Delbridge; Brandon J Aubrey; Cassandra J Vandenberg; Andreas Strasser
Journal:  Cell Rep       Date:  2016-03-03       Impact factor: 9.423

5.  Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias.

Authors:  Rachel Thijssen; Sarah T Diepstraten; Donia Moujalled; Edward Chew; Christoffer Flensburg; Melissa X Shi; Michael A Dengler; Veronique Litalien; Sarah MacRaild; Maoshan Chen; Natasha S Anstee; Boris Reljić; Sarah S Gabriel; Tirta M Djajawi; Chris D Riffkin; Brandon J Aubrey; Catherine Chang; Lin Tai; Zhen Xu; Thomas Morley; Giovanna Pomilio; Claudia Bruedigam; Axel Kallies; David A Stroud; Ashish Bajel; Ruth M Kluck; Steven W Lane; Marie Schoumacher; Sébastien Banquet; Ian J Majewski; Andreas Strasser; Andrew W Roberts; David C S Huang; Fiona C Brown; Gemma L Kelly; Andrew H Wei
Journal:  Blood       Date:  2021-05-20       Impact factor: 22.113

6.  Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53.

Authors:  Gemma L Kelly; Stephanie Grabow; Stefan P Glaser; Leah Fitzsimmons; Brandon J Aubrey; Toru Okamoto; Liz J Valente; Mikara Robati; Lin Tai; W Douglas Fairlie; Erinna F Lee; Mikael S Lindstrom; Klas G Wiman; David C S Huang; Philippe Bouillet; Martin Rowe; Alan B Rickinson; Marco J Herold; Andreas Strasser
Journal:  Genes Dev       Date:  2014-01-01       Impact factor: 11.361

7.  The landscape of somatic copy-number alteration across human cancers.

Authors:  Rameen Beroukhim; Craig H Mermel; Dale Porter; Guo Wei; Soumya Raychaudhuri; Jerry Donovan; Jordi Barretina; Jesse S Boehm; Jennifer Dobson; Mitsuyoshi Urashima; Kevin T Mc Henry; Reid M Pinchback; Azra H Ligon; Yoon-Jae Cho; Leila Haery; Heidi Greulich; Michael Reich; Wendy Winckler; Michael S Lawrence; Barbara A Weir; Kumiko E Tanaka; Derek Y Chiang; Adam J Bass; Alice Loo; Carter Hoffman; John Prensner; Ted Liefeld; Qing Gao; Derek Yecies; Sabina Signoretti; Elizabeth Maher; Frederic J Kaye; Hidefumi Sasaki; Joel E Tepper; Jonathan A Fletcher; Josep Tabernero; José Baselga; Ming-Sound Tsao; Francesca Demichelis; Mark A Rubin; Pasi A Janne; Mark J Daly; Carmelo Nucera; Ross L Levine; Benjamin L Ebert; Stacey Gabriel; Anil K Rustgi; Cristina R Antonescu; Marc Ladanyi; Anthony Letai; Levi A Garraway; Massimo Loda; David G Beer; Lawrence D True; Aikou Okamoto; Scott L Pomeroy; Samuel Singer; Todd R Golub; Eric S Lander; Gad Getz; William R Sellers; Matthew Meyerson
Journal:  Nature       Date:  2010-02-18       Impact factor: 49.962
  7 in total

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