BACKGROUND: As immunity against SARS-COV-2 wanes following first and second doses of vaccination, a third dose is administered in several countries around the world. Similarly to the first doses, risks related to vaccination and humoral immune response in patients with multiple sclerosis (MS) need to be assessed. OBJECTIVE: Characterize safety and humoral immune response following the third dose of COVID-19 vaccination in a large cohort of MS patients. METHODS: We assessed the safety of the third dose of the BNT162b2-COVID-19 mRNA vaccination in adult MS patients and evaluated SARS-CoV-2 IgG response. RESULTS: Two hundred and eleven adult MS patients received a third dose of BNT162b2 COVID-19 vaccination. Median follow up time was 66 days from vaccine administration (IQR 54-84). The frequency of any adverse event was 54.5%, with the most common reported adverse events being fatigue, local pain at the injection site, fever and muscle or joint pain. Transient increase in MS symptoms was reported in 3.8% of patients, none of them requiring treatment. The rate of acute relapses treated with IV steroids was 3.3%. In a sub-group of 55 patients, 20 untreated and 35 treated with vaccination-safe disease-modifying treatments, SARS-CoV-2 IgG levels increased 21-fold (median ± SD 21.6 ± 53.05). CONCLUSIONS: The third dose of COVID-19-BNT162b2 vaccine proved safe for MS patients, with no increased risk of relapse activity. Untreated patients and patients treated with vaccination-safe disease-modifying treatments show significant increase in SARS-CoV-2 IgG levels following the third dose of vaccination.
BACKGROUND: As immunity against SARS-COV-2 wanes following first and second doses of vaccination, a third dose is administered in several countries around the world. Similarly to the first doses, risks related to vaccination and humoral immune response in patients with multiple sclerosis (MS) need to be assessed. OBJECTIVE: Characterize safety and humoral immune response following the third dose of COVID-19 vaccination in a large cohort of MS patients. METHODS: We assessed the safety of the third dose of the BNT162b2-COVID-19 mRNA vaccination in adult MS patients and evaluated SARS-CoV-2 IgG response. RESULTS: Two hundred and eleven adult MS patients received a third dose of BNT162b2 COVID-19 vaccination. Median follow up time was 66 days from vaccine administration (IQR 54-84). The frequency of any adverse event was 54.5%, with the most common reported adverse events being fatigue, local pain at the injection site, fever and muscle or joint pain. Transient increase in MS symptoms was reported in 3.8% of patients, none of them requiring treatment. The rate of acute relapses treated with IV steroids was 3.3%. In a sub-group of 55 patients, 20 untreated and 35 treated with vaccination-safe disease-modifying treatments, SARS-CoV-2 IgG levels increased 21-fold (median ± SD 21.6 ± 53.05). CONCLUSIONS: The third dose of COVID-19-BNT162b2 vaccine proved safe for MS patients, with no increased risk of relapse activity. Untreated patients and patients treated with vaccination-safe disease-modifying treatments show significant increase in SARS-CoV-2 IgG levels following the third dose of vaccination.
Authors: Agata Czarnowska; Joanna Tarasiuk; Olga Zajkowska; Marcin Wnuk; Monika Marona; Klaudia Nowak; Agnieszka Słowik; Anna Jamroz-Wiśniewska; Konrad Rejdak; Beata Lech; Małgorzata Popiel; Iwona Rościszewska-Żukowska; Adam Perenc; Halina Bartosik-Psujek; Mariola Świderek-Matysiak; Małgorzata Siger; Agnieszka Ciach; Agata Walczak; Anna Jurewicz; Mariusz Stasiołek; Karolina Kania; Klara Dyczkowska; Alicja Kalinowska-Łyszczarz; Weronika Galus; Anna Walawska-Hrycek; Ewa Krzystanek; Justyna Chojdak-Łukasiewicz; Jakub Ubysz; Anna Pokryszko-Dragan; Katarzyna Kapica-Topczewska; Monika Chorąży; Marcin Bazylewicz; Anna Mirończuk; Joanna Kulikowska; Jan Kochanowicz; Marta Białek; Małgorzata Stolarz; Katarzyna Kubicka-Bączyk; Natalia Niedziela; Paweł Warmus; Monika Adamczyk-Sowa; Aleksandra Podlecka-Piçtowska; Monika Nojszewska; Beata Zakrzewska-Pniewska; Elżbieta Jasińska; Jacek Zaborski; Marta Milewska-Jȩdrzejczak; Jacek Zwiernik; Beata Zwiernik; Andrzej Potemkowski; Waldemar Brola; Alina Kułakowska Journal: Front Neurol Date: 2022-06-14 Impact factor: 4.086
Authors: Niklas Frahm; Firas Fneish; David Ellenberger; Judith Haas; Micha Loebermann; Tina Parciak; Melanie Peters; Dieter Pöhlau; Jeff Rodgers; Anna-Lena Röper; Sarah Schilling; Alexander Stahmann; Herbert Temmes; Uwe K Zettl; Rodden M Middleton Journal: Lancet Reg Health Eur Date: 2022-09-02