Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Binding of basic drugs to rat lung mitochondria.

Literature DB >> 3509138

Binding of basic drugs to rat lung mitochondria.

Abstract

The role of the mitochondria in the accumulation of basic amine drugs in the rat lung was studied. Drug binding to the mitochondria was rapid and reached maximum levels after 2.5 min of incubation. Lipophilic basic drugs accumulated in the mitochondria more than nonlipophilic basic drugs and nonbasic drugs, and the accumulation was dose dependent. Schatchard plots revealed at least two independent sets of binding sites for basic drugs in the mitochondria. The binding was competitively inhibited by other basic drugs but not nonbasic drugs. The degree of inhibition by competing basic drugs was correlated with their lipid solubilities. These findings with isolated mitochondria agree with previous results obtained with the perfused lung preparation and indicate that the mitochondria play an important role in the accumulation of basic drugs in the lung.

Entities: Chemical Species

Mesh：

Substances：

Year: 1987 PMID： 3509138 DOI： 10.1023/a:1016423220624

Source DB: PubMed Journal: Pharm Res ISSN： 0724-8741 Impact factor: 4.200

11 in total

Binding of basic drugs to rat lung mitochondria.

Review 1. Uptake, release and metabolism of drugs in the lungs.

2. The estimation of basic organic compounds in biological material; estimation of fluorescent compounds.

3. Protein measurement with the Folin phenol reagent.

4. The fluorimetric estimation of N1-methylnicotinamide and its differentiation from coenzyme.

5. Binding of propranolol and chlorpromazine by mitochondrial membranes.

6. Tissue distribution and metabolism of drugs. IV. Accumulation and penetration of some antibiotics in rat lungs.

Review 7. THe localization, metabolism and effects of drugs and toxicants in lung.

8. Chlorphentermine binding in rat lung subcellular fractions and its displacement by desmethylimipramine.

9. Studies on the uptake and binding of propranolol by rat tissues.

10. Prostaglandin E1 uptake by isolated cat lungs perfused with physiological salt solution.

Review 1. Methods of determining plasma and tissue binding of drugs. Pharmacokinetic consequences.

2. Contribution of monoamine oxidase(MAO) to the binding of tertiary basic drugs in isolated perfused rat lung.

3. Binding of bepridil to isolated rat heart mitochondria.

4. Contribution of monoamine oxidase (MAO) to the binding of tertiary basic drugs in lung mitochondria.

5. Contribution of lysosomes to the subcellular distribution of basic drugs in the rat liver.