Literature DB >> 35087335

Factors Associated With Elevated Inflammatory Markers Prior to Shoulder Arthroplasty.

Kyle J Kopechek1, Gregory L Cvetanovich1, Joshua S Everhart1, Travis L Frantz1, Richard Samade1, Julie Y Bishop1, Andrew S Neviaser1.   

Abstract

Background: Preoperative erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) ranges for several shoulder arthroplasty indications are not well understood. Purpose: We sought to compare preoperative ESR and CRP values for a variety of shoulder arthroplasty indications and evaluate risk factors for elevated preoperative ESR and CRP values.
Methods: We conducted a retrospective cohort study of shoulder arthroplasty cases performed at a single academic medical institution from 2013 to 2018. Preoperative ESR and CRP values for 235 shoulder arthroplasties with various indications were recorded. Independent risk factors for elevated values (CRP > 10.0 mg/L and ESR > 30.0 mm/h) were determined via multiple variable logistic regression.
Results: Patients undergoing shoulder arthroplasty for osteoarthritis had an ESR (mean ± SD) of 22.6 ± 17.8, with 29.8% of patients elevated, and a CRP of 6.5 ± 6.4, with 25.5% of patients elevated. Arthroplasty for acute fracture and prosthetic joint infection (PJI) had higher preoperative ESR and CRP values. Multivariate analysis identified several predictors of elevated ESR, including infection, acute fracture, diabetes, and female sex. It also identified predictors of elevated CRP, including infection, acute fracture, and younger age. Conclusions: Preoperative ESR and CRP values may be elevated in 25% to 30% of patients undergoing primary shoulder arthroplasty. Arthroplasty for both acute fracture and PJI, along with several other patient factors, was associated with elevated preoperative ESR and CRP. Thus, routine collection of ESR and CRP preoperatively may not be of benefit, as elevated values are common. Further study is warranted.
© The Author(s) 2021.

Entities:  

Keywords:  CRP; ESR; TSA; periprosthetic joint infection; rTSA; shoulder arthroplasty

Year:  2021        PMID: 35087335      PMCID: PMC8753553          DOI: 10.1177/1556331621998662

Source DB:  PubMed          Journal:  HSS J        ISSN: 1556-3316


  38 in total

Review 1.  Prevalence and projections of total shoulder and elbow arthroplasty in the United States to 2015.

Authors:  Judd S Day; Edmund Lau; Kevin L Ong; Gerald R Williams; Matthew L Ramsey; Steven M Kurtz
Journal:  J Shoulder Elbow Surg       Date:  2010-06-15       Impact factor: 3.019

2.  Proceedings from the 2018 International Consensus Meeting on Orthopedic Infections: the definition of periprosthetic shoulder infection.

Authors:  Grant E Garrigues; Benjamin Zmistowski; Alexus M Cooper; Andrew Green
Journal:  J Shoulder Elbow Surg       Date:  2019-06       Impact factor: 3.019

3.  Propionibacterium acnes infection after shoulder arthroplasty: a diagnostic challenge.

Authors:  Christopher C Dodson; Edward V Craig; Frank A Cordasco; David M Dines; Joshua S Dines; Edward Dicarlo; Barry D Brause; Russell F Warren
Journal:  J Shoulder Elbow Surg       Date:  2009-11-01       Impact factor: 3.019

4.  Clinical significance of extreme elevation of the erythrocyte sedimentation rate.

Authors:  R M Fincher; M I Page
Journal:  Arch Intern Med       Date:  1986-08

5.  C-reactive protein may misdiagnose prosthetic joint infections, particularly chronic and low-grade infections.

Authors:  Daniel Pérez-Prieto; María E Portillo; Lluís Puig-Verdié; Albert Alier; Santos Martínez; Lluisa Sorlí; Juan P Horcajada; Joan C Monllau
Journal:  Int Orthop       Date:  2017-03-21       Impact factor: 3.075

6.  C-reactive protein, erythrocyte sedimentation rate and orthopedic implant infection.

Authors:  Kerryl E Piper; Marta Fernandez-Sampedro; Kathryn E Steckelberg; Jayawant N Mandrekar; Melissa J Karau; James M Steckelberg; Elie F Berbari; Douglas R Osmon; Arlen D Hanssen; David G Lewallen; Robert H Cofield; John W Sperling; Joaquin Sanchez-Sotelo; Paul M Huddleston; Mark B Dekutoski; Michael Yaszemski; Bradford Currier; Robin Patel
Journal:  PLoS One       Date:  2010-02-22       Impact factor: 3.240

7.  Erythrocyte sedimentation rate and C-reactive protein values in patients with total hip arthroplasty.

Authors:  L Y Shih; J J Wu; D J Yang
Journal:  Clin Orthop Relat Res       Date:  1987-12       Impact factor: 4.176

8.  C-reactive protein levels for early detection of postoperative infection after fracture surgery in 787 patients.

Authors:  Markus Neumaier; Michael A Scherer
Journal:  Acta Orthop       Date:  2008-06       Impact factor: 3.717

9.  C-reactive protein level after total hip and total knee replacement.

Authors:  J White; M Kelly; R Dunsmuir
Journal:  J Bone Joint Surg Br       Date:  1998-09

10.  Screening for Periprosthetic Joint Infections With ESR and CRP: The Ideal Cutoffs.

Authors:  Joshua S Bingham; Jeffrey D Hassebrock; Austin L Christensen; Christopher P Beauchamp; Henry D Clarke; Mark J Spangehl
Journal:  J Arthroplasty       Date:  2019-12-02       Impact factor: 4.757

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  2 in total

1.  Screening For and Evaluation of Inflammation Prior to TJA Has Implications for Perioperative Care and Outcomes.

Authors:  Steven S Overman
Journal:  HSS J       Date:  2022-06-03

2.  A Broader View.

Authors:  Charles N Cornell
Journal:  HSS J       Date:  2022-05-19
  2 in total

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