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Literature DB >> 3508530

Subcellular distribution of basic drugs accumulated in the isolated perfused lung.

Abstract

To clarify the mechanism by which basic drugs accumulate in the lung, the binding selectivity of drugs to different subcellular structures of the perfused rat lung was examined. Imipramine, quinine, and metoclopramide were used as examples of basic drugs. The accumulation of basic drugs was highest in the mitochondrial fraction. The drug accumulation in the lung mitochondrial fraction increased with increasing lipid solubility and was dose dependent. These results suggest the presence of specific binding sites for basic drugs in mitochondria and that mitochondria play an important role as a reservoir for basic drugs.

Entities: Chemical Species

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Year: 1987 PMID： 3508530 DOI： 10.1023/a:1016481911538

Source DB: PubMed Journal: Pharm Res ISSN： 0724-8741 Impact factor: 4.200

11 in total

1. On the mechanism of intestinal absorption of drugs.

Authors: C A HOGBEN; D J TOCCO; B B BRODIE; L S SCHANKER
Journal: J Pharmacol Exp Ther Date: 1959-04 Impact factor: 4.030

2. Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue.

Authors: C DE DUVE; B C PRESSMAN; R GIANETTO; R WATTIAUX; F APPELMANS
Journal: Biochem J Date: 1955-08 Impact factor: 3.857

3. The estimation of basic organic compounds in biological material; estimation of fluorescent compounds.

Authors: B B BRODIE; S UDENFRIEND
Journal: J Biol Chem Date: 1947-04 Impact factor: 5.157

4. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

5. A microspectrophotometric method for the determination of cytochrome oxidase.

Authors: S J COOPERSTEIN; A LAZAROW
Journal: J Biol Chem Date: 1951-04 Impact factor: 5.157

6. Carbon-11 labeled aliphatic amines in lung uptake and metabolism studies: potential for dynamic measurements in vivo.

Authors: J S Fowler; B M Gallagher; R R MacGregor; A P Wolf
Journal: J Pharmacol Exp Ther Date: 1976-07 Impact factor: 4.030

7. Preparation and properties of plasma membrane and endoplasmic reticulum fragments from isolated rat fat cells.

Authors: J Avruch; D F Wallach
Journal: Biochim Biophys Acta Date: 1971-04-13

8. Preparation of lung microsomes and a comparison of the distribution of enzymes between subcellular fractions of rabbit lung and liver.

Authors: G E Hook; J R Bend; D Hoel; J R Fouts; T E Gram
Journal: J Pharmacol Exp Ther Date: 1972-09 Impact factor: 4.030

Subcellular distribution of basic drugs accumulated in the isolated perfused lung.

1. On the mechanism of intestinal absorption of drugs.

2. Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue.

3. The estimation of basic organic compounds in biological material; estimation of fluorescent compounds.

4. Protein measurement with the Folin phenol reagent.

5. A microspectrophotometric method for the determination of cytochrome oxidase.

6. Carbon-11 labeled aliphatic amines in lung uptake and metabolism studies: potential for dynamic measurements in vivo.

7. Preparation and properties of plasma membrane and endoplasmic reticulum fragments from isolated rat fat cells.

8. Preparation of lung microsomes and a comparison of the distribution of enzymes between subcellular fractions of rabbit lung and liver.

9. Tissue distribution and metabolism of drugs. IV. Accumulation and penetration of some antibiotics in rat lungs.

10. Studies on the uptake and binding of propranolol by rat tissues.

1. Contribution of monoamine oxidase(MAO) to the binding of tertiary basic drugs in isolated perfused rat lung.

2. Role of phosphatidylserine in the cellular and subcellular lung distribution of quinidine in rats.

Review 3. The subcellular distribution of small molecules: from pharmacokinetics to synthetic biology.

4. Contribution of monoamine oxidase (MAO) to the binding of tertiary basic drugs in lung mitochondria.

5. Effects of 2,4-dichlorophenoxyacetic acid butyl ester on chick liver.