Literature DB >> 3508525

A reversed-phase high-performance liquid chromatography assay procedure for progabide and its related metabolic derivatives.

N F Farraj1, S S Davis, G D Parr, H N Stevens.   

Abstract

A reversed-phase high-performance liquid chromatography (HPLC) assay procedure for Progabide, its active acid metabolite (PGA), and its hydrolytic degradation product (SL79.182) has been developed. This highly specific technique has allowed the simultaneous determination of these drugs in aqueous samples, and when coupled with a single and easy extraction step, spiked plasma samples could also be analyzed. The method had a sensitivity of about 30, 45, and 100 ng/ml for Progabide, SL79.182, and PGA, respectively.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 3508525     DOI： 10.1023/a:1016421725650

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  7 in total

1.  The stability and solubility of progabide and its related metabolic derivatives.

Authors:  N F Farraj; S S Davis; G D Parr; H N Stevens
Journal:  Pharm Res       Date:  1988-04       Impact factor: 4.200

2.  Gas chromatographic method for the determination of progabide (SL 76.002) in biological fluids.

Authors:  G Gillet; J Fraisse-André; C R Lee; L G Dring; P L Morselli
Journal:  J Chromatogr       Date:  1982-06-11

3.  Determination of progabide and its acid metabolite in biological fluids by high-performance liquid chromatography on silica column with ultraviolet detection.

Authors:  V Ascalone; P Catalani; L Dal Bò
Journal:  J Chromatogr       Date:  1985-11-08

4.  Measurement of progabide and its deaminated metabolite in plasma by high-performance liquid chromatography and electrochemical detection.

Authors:  W Yonekawa; H J Kupferberg; T Lambert
Journal:  J Chromatogr       Date:  1983-08-12

5.  Pharmacokinetic profile of progabide, a new gamma-aminobutyric acid-mimetic drug, in rhesus monkey.

Authors:  I Johno; B T Ludwick; R H Levy
Journal:  J Pharm Sci       Date:  1982-06       Impact factor: 3.534

6.  Determination of progabide and its main acid metabolite in biological fluids using high-performance liquid chromatography and electrochemical detection. Application to the measurement of blood/plasma partition ratio.

Authors:  P Padovani; C Deves; G Bianchetti; J P Thenot; P L Morselli
Journal:  J Chromatogr       Date:  1984-06-08

7.  New anticonvulsants: Schiff bases of gamma-aminobutyric acid and gamma-aminobutyramide.

Authors:  J P Kaplan; B M Raizon; M Desarmenien; P Feltz; P M Headley; P Worms; K G Lloyd; G Bartholini
Journal:  J Med Chem       Date:  1980-06       Impact factor: 7.446
  7 in total
  1 in total

1.  The stability and solubility of progabide and its related metabolic derivatives.

Authors:  N F Farraj; S S Davis; G D Parr; H N Stevens
Journal:  Pharm Res       Date:  1988-04       Impact factor: 4.200
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.