| Literature DB >> 35084970 |
Mercedes F Paredes1,2,3,4, Cristina Mora5, Quetzal Flores-Ramirez1, Arantxa Cebrian-Silla2,6, Ashley Del Dosso5, Phil Larimer1, Jiapei Chen3,5, Gugene Kang4,6, Susana Gonzalez Granero7, Eric Garcia1, Julia Chu1, Ryan Delgado2, Jennifer A Cotter8, Vivian Tang5, Julien Spatazza6, Kirsten Obernier6, Jaime Ferrer Lozano9, Maximo Vento10,11, Julia Scott12, Colin Studholme13,14,15, Tomasz J Nowakowski2,16, Arnold R Kriegstein1,2,3,4, Michael C Oldham4,5,6, Andrea Hasenstaub17, Jose Manuel Garcia-Verdugo7, Arturo Alvarez-Buylla2,3,4,6, Eric J Huang2,3,4,5.
Abstract
The human cortex contains inhibitory interneurons derived from the medial ganglionic eminence (MGE), a germinal zone in the embryonic ventral forebrain. How this germinal zone generates sufficient interneurons for the human brain remains unclear. We found that the human MGE (hMGE) contains nests of proliferative neuroblasts with ultrastructural and transcriptomic features that distinguish them from other progenitors in the hMGE. When dissociated hMGE cells are transplanted into the neonatal mouse brain, they reform into nests containing proliferating neuroblasts that generate young neurons that migrate extensively into the mouse forebrain and mature into different subtypes of functional interneurons. Together, these results indicate that the nest organization and sustained proliferation of neuroblasts in the hMGE provide a mechanism for the extended production of interneurons for the human forebrain.Entities:
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Year: 2022 PMID： 35084970 PMCID： PMC8887556 DOI： 10.1126/science.abk2346
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 63.714