OBJECTIVE: To evaluate the relationship between diurnal salivary cortisol patterns and distress from heart palpitations in midlife women. METHODS: We analyzed baseline data from 293 women who were eligible for a 3 × 2 factorial trial of exercise or yoga versus routine activity, and omega-3 fish oil versus placebo for vasomotor symptoms. Women self-collected salivary cortisol using swabs at four time points over 2 consecutive days and reported distress from heart racing or pounding during the past 2 weeks using a single item. Sample description and covariate data included demographics, clinical data, vasomotor symptom frequency from daily diaries, medication use, and validated questionnaires on depression, stress, and insomnia (Patient Health Questionnaire-8, Perceived Stress Scale, and Insomnia Severity index). Data were analyzed using descriptive statistics, chi-square and t tests, and repeated measure linear regression models. RESULTS: Participants were on average 54.6 (SD = 3.6) years old, most were White (67%) postmenopausal (84%), and 26% reported distress related to palpitations. In adjusted models, the morning (wake plus 30-min) geometric mean daily salivary cortisol concentrations were significantly more blunted in those with distress from palpitations compared with those without distress (P ≤ 0.03). When all covariates were controlled, distress from palpitations was the sole significant predictor of wake plus 30-minute cortisol (-0.25 [-0.45 to -0.04], P = 0.02). CONCLUSIONS: Palpitations among midlife women may be associated with blunted morning cortisol, and this relationship is not explained by demographics, clinical variables, vasomotor symptoms, medications, depression, stress, or insomnia.
OBJECTIVE: To evaluate the relationship between diurnal salivary cortisol patterns and distress from heart palpitations in midlife women. METHODS: We analyzed baseline data from 293 women who were eligible for a 3 × 2 factorial trial of exercise or yoga versus routine activity, and omega-3 fish oil versus placebo for vasomotor symptoms. Women self-collected salivary cortisol using swabs at four time points over 2 consecutive days and reported distress from heart racing or pounding during the past 2 weeks using a single item. Sample description and covariate data included demographics, clinical data, vasomotor symptom frequency from daily diaries, medication use, and validated questionnaires on depression, stress, and insomnia (Patient Health Questionnaire-8, Perceived Stress Scale, and Insomnia Severity index). Data were analyzed using descriptive statistics, chi-square and t tests, and repeated measure linear regression models. RESULTS: Participants were on average 54.6 (SD = 3.6) years old, most were White (67%) postmenopausal (84%), and 26% reported distress related to palpitations. In adjusted models, the morning (wake plus 30-min) geometric mean daily salivary cortisol concentrations were significantly more blunted in those with distress from palpitations compared with those without distress (P ≤ 0.03). When all covariates were controlled, distress from palpitations was the sole significant predictor of wake plus 30-minute cortisol (-0.25 [-0.45 to -0.04], P = 0.02). CONCLUSIONS: Palpitations among midlife women may be associated with blunted morning cortisol, and this relationship is not explained by demographics, clinical variables, vasomotor symptoms, medications, depression, stress, or insomnia.
Authors: Ying Sheng; Janet S Carpenter; Charles D Elomba; Jennifer S Alwine; Min Yue; Caitlin A Pike; Chen X Chen; James E Tisdale Journal: Womens Midlife Health Date: 2021-05-31
Authors: Janet S Carpenter; James E Tisdale; Chen X Chen; Richard Kovacs; Joseph C Larson; Katherine A Guthrie; Kristine E Ensrud; Katherine M Newton; Andrea Z LaCroix Journal: J Womens Health (Larchmt) Date: 2020-11-20 Impact factor: 3.017
Authors: Katherine M Newton; Janet S Carpenter; Katherine A Guthrie; Garnet L Anderson; Bette Caan; Lee S Cohen; Kristine E Ensrud; Ellen W Freeman; Hadine Joffe; Barbara Sternfeld; Susan D Reed; Sheryl Sherman; Mary D Sammel; Kurt Kroenke; Joseph C Larson; Andrea Z Lacroix Journal: Menopause Date: 2014-01 Impact factor: 3.310
Authors: Barbara Sternfeld; Andrea LaCroix; Bette J Caan; Andrea L Dunn; Katherine M Newton; Susan D Reed; Katherine A Guthrie; Cathryn Booth-LaForce; Karen J Sherman; Lee Cohen; Marlene P Freeman; Janet S Carpenter; Julie R Hunt; Melanie Roberts; Kristine E Ensrud Journal: Contemp Clin Trials Date: 2013-02-24 Impact factor: 2.261