Literature DB >> 35083450

Neutrophil response to cyclophosphamide predicts resilience to age-related learning impairment.

Katie Nickel1, Marianne Bjorner1, Warren Ladiges1, Lida Zhu1.   

Abstract

The ability to respond to stress, defined as resilience, was measured by white blood cell counts in C57BL/6 mice of various ages receiving a nonlethal dose of cyclophosphamide (CYP). Neutrophil counts dipped and then rebounded in a consistent and age-dependent manner. Low neutrophil rebound correlated with improved learning in middle-age mice suggesting CYP-nduced neutrophil response may predict resilience to aging.

Entities:  

Keywords:  Resilience to aging; aging mice; ear punch biopsy; wound healing

Year:  2020        PMID： 35083450      PMCID： PMC8789152          DOI： 10.31491/apt.2020.12.046

Source DB:  PubMed          Journal:  Aging Pathobiol Ther        ISSN： 2690-1803


  4 in total

1.  Development of a cyclophosphamide stress test to predict resilience to aging in mice.

Authors:  Lida Zhu; Yan Dou; Marianne Bjorner; Warren Ladiges
Journal:  Geroscience       Date:  2020-07-01       Impact factor: 7.713

2.  A Novel One-Day Learning Procedure for Mice.

Authors:  Martin Darvas; Kishore Mukherjee; Amanda Lee; Warren Ladiges
Journal:  Curr Protoc Mouse Biol       Date:  2020-03

3.  A comparative analysis of low-dose metronomic cyclophosphamide reveals absent or low-grade toxicity on tissues highly sensitive to the toxic effects of maximum tolerated dose regimens.

Authors:  Urban Emmenegger; Shan Man; Yuval Shaked; Giulio Francia; John W Wong; Daniel J Hicklin; Robert S Kerbel
Journal:  Cancer Res       Date:  2004-06-01       Impact factor: 12.701

Review 4.  The potential use of physical resilience to predict healthy aging.

Authors:  Anna Schorr; Christy Carter; Warren Ladiges
Journal:  Pathobiol Aging Age Relat Dis       Date:  2017-11-21
  4 in total

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