Shunming Zhang1,2,3, Ge Meng2,4, Qing Zhang5, Li Liu5, Hongmei Wu2, Yeqing Gu1, Yawen Wang2, Tingjing Zhang2, Xuena Wang2, Juanjuan Zhang2, Shaomei Sun5, Xing Wang5, Ming Zhou5, Qiyu Jia5, Kun Song5, Yaogang Wang2, Lu Qi6,7, Kaijun Niu8,9,10,11,12. 1. Nutrition and Radiation Epidemiology Research Center, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China. 2. Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China. 3. Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden. 4. Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin, China. 5. Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China. 6. Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA. lqi1@tulane.edu. 7. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. lqi1@tulane.edu. 8. Nutrition and Radiation Epidemiology Research Center, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China. nkj0809@gmail.com. 9. Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China. nkj0809@gmail.com. 10. Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China. nkj0809@gmail.com. 11. Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China. nkj0809@gmail.com. 12. Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin, China. nkj0809@gmail.com.
Abstract
BACKGROUND/ OBJECTIVES: Diet is an important factor that can exacerbate or ameliorate chronic inflammation, which has been implicated in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). However, no prospective study has yet investigated the relation between the inflammatory potential of diet and NAFLD. The aim of this study was to investigate the association between the inflammatory potential of the diet and the risk of NAFLD. SUBJECT/ METHODS: The study included 12,877 participants aged over 18 years (mean [standard deviation]: 39.4 [11.5] years). Dietary intake was assessed at baseline through food frequency questionnaires. Using white blood cell count as the inflammatory marker, we newly created a dietary inflammatory potential score by reduced rank regression and stepwise linear regression. NAFLD was identified by abdominal ultrasound during yearly health checkups. Cox proportional hazards regression models were used to estimate the association between the dietary inflammatory potential score and the risk of NAFLD. RESULTS: During a median follow-up period of 4.2 years, 2744 first incident cases of NAFLD occurred. After adjustment for potential confounders, the multivariable hazards ratios (95% confidence intervals) for NAFLD across increasing quartiles of the dietary inflammatory potential score were 1.00 (reference), 1.01 (0.90, 1.13), 1.15 (1.03, 1.29), and 1.26 (1.13, 1.41), with P for trend <0.0001. This positive association appeared greater in men than in women (P for interaction = 0.02). CONCLUSIONS: Our results indicate that a dietary pattern with high inflammatory potential is associated with a higher risk of NAFLD. Such findings provide the support that inflammation may be a potential mechanism linking diet to the risk of NAFLD.
BACKGROUND/ OBJECTIVES: Diet is an important factor that can exacerbate or ameliorate chronic inflammation, which has been implicated in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). However, no prospective study has yet investigated the relation between the inflammatory potential of diet and NAFLD. The aim of this study was to investigate the association between the inflammatory potential of the diet and the risk of NAFLD. SUBJECT/ METHODS: The study included 12,877 participants aged over 18 years (mean [standard deviation]: 39.4 [11.5] years). Dietary intake was assessed at baseline through food frequency questionnaires. Using white blood cell count as the inflammatory marker, we newly created a dietary inflammatory potential score by reduced rank regression and stepwise linear regression. NAFLD was identified by abdominal ultrasound during yearly health checkups. Cox proportional hazards regression models were used to estimate the association between the dietary inflammatory potential score and the risk of NAFLD. RESULTS: During a median follow-up period of 4.2 years, 2744 first incident cases of NAFLD occurred. After adjustment for potential confounders, the multivariable hazards ratios (95% confidence intervals) for NAFLD across increasing quartiles of the dietary inflammatory potential score were 1.00 (reference), 1.01 (0.90, 1.13), 1.15 (1.03, 1.29), and 1.26 (1.13, 1.41), with P for trend <0.0001. This positive association appeared greater in men than in women (P for interaction = 0.02). CONCLUSIONS: Our results indicate that a dietary pattern with high inflammatory potential is associated with a higher risk of NAFLD. Such findings provide the support that inflammation may be a potential mechanism linking diet to the risk of NAFLD.
Authors: Chris Estes; Quentin M Anstee; Maria Teresa Arias-Loste; Heike Bantel; Stefano Bellentani; Joan Caballeria; Massimo Colombo; Antonio Craxi; Javier Crespo; Christopher P Day; Yuichiro Eguchi; Andreas Geier; Loreta A Kondili; Daniela C Kroy; Jeffrey V Lazarus; Rohit Loomba; Michael P Manns; Giulio Marchesini; Atsushi Nakajima; Francesco Negro; Salvatore Petta; Vlad Ratziu; Manuel Romero-Gomez; Arun Sanyal; Jörn M Schattenberg; Frank Tacke; Junko Tanaka; Christian Trautwein; Lai Wei; Stefan Zeuzem; Homie Razavi Journal: J Hepatol Date: 2018-06-08 Impact factor: 25.083
Authors: Alessandro Mantovani; Graziana Petracca; Giorgia Beatrice; Alessandro Csermely; Amedeo Lonardo; Jörn M Schattenberg; Herbert Tilg; Christopher D Byrne; Giovanni Targher Journal: Gut Date: 2020-12-10 Impact factor: 23.059
Authors: Alessandro Mantovani; Graziana Petracca; Giorgia Beatrice; Herbert Tilg; Christopher D Byrne; Giovanni Targher Journal: Gut Date: 2020-09-16 Impact factor: 23.059
Authors: Anne M Minihane; Sophie Vinoy; Wendy R Russell; Athanasia Baka; Helen M Roche; Kieran M Tuohy; Jessica L Teeling; Ellen E Blaak; Michael Fenech; David Vauzour; Harry J McArdle; Bas H A Kremer; Luc Sterkman; Katerina Vafeiadou; Massimo Massi Benedetti; Christine M Williams; Philip C Calder Journal: Br J Nutr Date: 2015-07-31 Impact factor: 3.718