Maria Perrone1, Carlo Garufi2, Maurizio Cosimelli3, Franco Graziano4, Chiara Falcicchio5, Alessandro Bonucci5, Luana Fotia5, Diana Giannarelli6, Luca Giacomelli7, Gennaro Ciliberto8, Patrizia Pugliese5. 1. Psychology Unit, IRCCS Regina Elena Cancer Institute, Rome, Italy. maria.perrone@ifo.gov.it. 2. Medical Oncology, Azienda Ospedaliera San Camillo Forlanini Roma, Rome, Italy. 3. Colon Rectal Surgery, Fondazione IRCCS Istituto Nazionale Dei Tumori, S.C. Oncological 2 , Milan, Italy. 4. Department of Surgery, IRCCS Regina Elena Cancer Institute, Rome, Italy. 5. Psychology Unit, IRCCS Regina Elena Cancer Institute, Rome, Italy. 6. Biostatistics Unit, IRCCS Regina Elena Cancer Institute, Rome, Italy. 7. Polistudium SRL, Milan, Italy. 8. Scientific Direction, IRCCS Regina Elena Cancer Institute, Rome, Italy.
Abstract
PURPOSE: The major improvements in the diagnosis and treatment of colorectal cancer (CRC) over the past decades increased the patients' survival rates. Despite this, patients and clinicians still need to address the long-term physical and psychosocial effects over time. This paper aims to prospectively assess CRC patients' HR-QoL psychological distress and sexual functioning and identify clinical, demographic, and psychological predictors. METHODS: In total, 55 patients were evaluated from diagnosis to 5-year follow-up with the following instruments: EORTC QLQ-C30 and QLQ-C38 for QoL and sexuality; HADS for psychological distress; and specific questions to detect psychological variables. RESULTS: QoL worsened after diagnosis and returned to baseline values after 5 years. Sexual function significantly deteriorated over time (with no recovery, especially in women), while borderline/severe anxiety and depression decreased. A better HR-QoL at baseline was associated with better physical, social and sexual functioning, positive body image and sexual pleasure after 5 years. CONCLUSION: HR-QoL allows the early detection of patients at risk, favoring prompt patient-centered interventions.
PURPOSE: The major improvements in the diagnosis and treatment of colorectal cancer (CRC) over the past decades increased the patients' survival rates. Despite this, patients and clinicians still need to address the long-term physical and psychosocial effects over time. This paper aims to prospectively assess CRC patients' HR-QoL psychological distress and sexual functioning and identify clinical, demographic, and psychological predictors. METHODS: In total, 55 patients were evaluated from diagnosis to 5-year follow-up with the following instruments: EORTC QLQ-C30 and QLQ-C38 for QoL and sexuality; HADS for psychological distress; and specific questions to detect psychological variables. RESULTS: QoL worsened after diagnosis and returned to baseline values after 5 years. Sexual function significantly deteriorated over time (with no recovery, especially in women), while borderline/severe anxiety and depression decreased. A better HR-QoL at baseline was associated with better physical, social and sexual functioning, positive body image and sexual pleasure after 5 years. CONCLUSION: HR-QoL allows the early detection of patients at risk, favoring prompt patient-centered interventions.
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