| Literature DB >> 35074700 |
Fleur Cordier1, Joni Van der Meulen2, Nadine van Roy3, Jilke De Wilde4, Herwig van Dijck5, Filip Vanhoenacker6, Marc Lambrechts7, Valentin Noyez8, Koen Van de Vijver9, Liesbeth Ferdinande10, Amélie Dendooven9, Jo Van Dorpe10, David Creytens11.
Abstract
Case report of malignant pleural mesothelioma with an ALK gene rearrangement, detected by FISH and confirmed by RNA-based next-generation sequencing. The co-occurrence of ALK gene fusions with the more common genetic alterations in CDKN2A, NF2 and BAP1 has, to our best knowledge, not yet been described in malignant mesothelioma. Furthermore, this unexpected finding could suggest a potential target for therapy in this subset of malignant mesotheliomas.Entities:
Keywords: ALK fusion; Copy-number variation sequencing; Immunohistochemistry; Molecular techniques; Next-generation sequencing; Pleural mesothelioma
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Year: 2022 PMID： 35074700 DOI： 10.1016/j.prp.2022.153772
Source DB: PubMed Journal: Pathol Res Pract ISSN： 0344-0338 Impact factor: 3.250