Literature DB >> 35072513

Case Commentary: Long-Term Fosmanogepix Use in a Transplant Recipient with Disseminated Aspergillosis Caused by Azole-Resistant Aspergillus calidoustus.

Ahnika Kline1, Michail S Lionakis1.   

Abstract

Aspergillus calidoustus is an emerging, azole-resistant, cryptic Aspergillus species in immunosuppressed patients that often features extrapulmonary involvement and carries high mortality. The case presented by J. F. Camargo, R. Jabr, A. D. Anderson, L. Lekakis, et al. (Antimicrob Agents Chemother 66:e02206-21, 2022, https://doi.org/10.1128/aac.02206-21) describes a transplant recipient with disseminated A. calidoustus infection who was successfully treated with surgical source control, tapering of immunosuppression, and long-term, combination antifungal treatment that included the first-in-class fosmanogepix, which targets fungal mannoprotein trafficking and anchoring.

Entities:  

Keywords:  Aspergillus calidoustus; azole resistance; cryptic Aspergillus species; disseminated aspergillosis; fosmanogepix

Mesh：

Substances：

Year:  2022        PMID： 35072513      PMCID： PMC8923175          DOI： 10.1128/aac.02368-21

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.938


  33 in total

Review 1.  Aspergillus calidoustus case series and review of the literature.

Authors:  Justin Seroy; Philip Antiporta; Shellee A Grim; Laurie A Proia; Kamaljit Singh; Nina M Clark
Journal:  Transpl Infect Dis       Date:  2017-09-19       Impact factor: 2.228

2.  Successful Treatment of Disseminated Disease Due to Highly Resistant Aspergillus calidoustus with a Novel Antifungal Therapy.

Authors:  Jose F Camargo; Ra'ed Jabr; Anthony D Anderson; Lazaros Lekakis; Meilin Diaz-Paez; Laurence M Briski; Mohammed Raja; Michele I Morris; Krishna V Komanduri; Denise Pereira
Journal:  Antimicrob Agents Chemother       Date:  2021-12-20       Impact factor: 5.938

3.  Clinical and Microbiological Characteristics of Proven Invasive Aspergillosis Due to Rare/Cryptic Species in Allogeneic Hematopoietic Stem Cell Transplant Recipients.

Authors:  Ryosuke Yamamuro; Muneyoshi Kimura; Yuki Asano-Mori; Masahiro Abe; Shigeki Nakamura; Takashi Umeyama; Satoshi Yamagoe; Yoshitsugu Miyazaki; Sho Ogura; Takashi Sakoh; Takashi Mitsuki; Kyosuke Yamaguchi; Mitsuhiro Yuasa; Daisuke Kaji; Kosei Kageyama; Aya Nishida; Yuki Taya; Kazuya Ishiwata; Shinsuke Takagi; Hisashi Yamamoto; Go Yamamoto; Naoyuki Uchida; Atsushi Wake; Shuichi Taniguchi; Hideki Araoka
Journal:  Antimicrob Agents Chemother       Date:  2021-11-15       Impact factor: 5.938

4.  In vitro activity of nine antifungal agents against clinical isolates of Aspergillus calidoustus.

Authors:  Ana Alastruey-Izquierdo; Isabel Cuesta; Jos Houbraken; Manuel Cuenca-Estrella; Araceli Monzón; Juan L Rodriguez-Tudela
Journal:  Med Mycol       Date:  2010-02       Impact factor: 4.076

5.  Invasive aspergillosis due to Aspergillus cryptic species: a prospective multicenter study.

Authors:  Sebastien Imbert; Sophie Cassaing; Christine Bonnal; Anne-Cecile Normand; Frederic Gabriel; Damien Costa; Marion Blaize; Laurence Lachaud; Lilia Hasseine; Lise Kristensen; Juliette Guitard; Christine Schuttler; Helene Raberin; Sophie Brun; Marijke Hendrickx; Renaud Piarroux; Arnaud Fekkar
Journal:  Mycoses       Date:  2021-06-28       Impact factor: 4.377

6.  Invasive Aspergillosis Due to Aspergillus Section Usti: A Multicenter Retrospective Study.

Authors:  Emmanouil Glampedakis; Sophie Cassaing; Arnaud Fekkar; Eric Dannaoui; Marie-Elisabeth Bougnoux; Stéphane Bretagne; Dionysios Neofytos; Peter W Schreiber; Christophe Hennequin; Florent Morio; Olga Shadrivova; Felix Bongomin; Mario Fernández-Ruiz; Anne Pauline Bellanger; Sevtap Arikan-Akdagli; Veronique Erard; Maria Aigner; Michela Paolucci; Nina Khanna; Eléna Charpentier; Christine Bonnal; Sophie Brun; Frederic Gabriel; Arnaud Riat; Reinhard Zbinden; Patrice Le Pape; Nikolai Klimko; Russel E Lewis; Malcolm Richardson; Ahmet Cagkan İnkaya; Alix T Coste; Pierre-Yves Bochud; Frederic Lamoth
Journal:  Clin Infect Dis       Date:  2021-04-26       Impact factor: 9.079

7.  Molecular identification of Aspergillus species collected for the Transplant-Associated Infection Surveillance Network.

Authors:  S Arunmozhi Balajee; Rui Kano; John W Baddley; Stephen A Moser; Kieren A Marr; Barbara D Alexander; David Andes; Dimitrios P Kontoyiannis; Giancarlo Perrone; Stephen Peterson; Mary E Brandt; Peter G Pappas; Tom Chiller
Journal:  J Clin Microbiol       Date:  2009-08-12       Impact factor: 5.948

8.  Population-based survey of filamentous fungi and antifungal resistance in Spain (FILPOP Study).

Authors:  A Alastruey-Izquierdo; E Mellado; T Peláez; J Pemán; S Zapico; M Alvarez; J L Rodríguez-Tudela; M Cuenca-Estrella
Journal:  Antimicrob Agents Chemother       Date:  2013-05-13       Impact factor: 5.191

9.  Aspergillus ustus infections among transplant recipients.

Authors:  Anil A Panackal; Alexander Imhof; Edward W Hanley; Kieren A Marr
Journal:  Emerg Infect Dis       Date:  2006-03       Impact factor: 6.883

10.  APX001 Is Effective in the Treatment of Murine Invasive Pulmonary Aspergillosis.

Authors:  Teclegiorgis Gebremariam; Sondus Alkhazraji; Abdullah Alqarihi; Heewon H Jeon; Yiyou Gu; Mili Kapoor; Karen J Shaw; Ashraf S Ibrahim
Journal:  Antimicrob Agents Chemother       Date:  2019-01-29       Impact factor: 5.191
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