Literature DB >> 3507235

Simple and rapid GLC method for the determination of orphenadrine in human plasma.

M Contin1, R Riva, F Albani, A Baruzzi.   

Abstract

A rapid and specific method has been developed for the determination of orphenadrine concentration in plasma. It involves a one-step sample preparation using n-hexane/isopropyl alcohol (98:2) extraction, and analysis by gas chromatography on a wide bore capillary column using nitrogen/phosphorus detection. This procedure considerably simplifies previously reported assays and is specific and sensitive enough for the determination of orphenadrine in plasma of patients on chronic therapy.

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Year:  1987        PMID： 3507235     DOI： 10.1002/bmc.1130020504

Source DB:  PubMed          Journal:  Biomed Chromatogr        ISSN： 0269-3879            Impact factor:   1.902


  5 in total

1.  Development of a capillary electrophoresis method for the determination of orphenadrine citrate in tablets in the presence of paracetamol.

Authors:  Dana N Haj-Ali; Imad I Hamdan
Journal:  Saudi Pharm J       Date:  2010-08-02       Impact factor: 4.330

2.  Orphenadrine prevents 3-nitropropionic acid-induced neurotoxicity in vitro and in vivo.

Authors:  D Pubill; E Verdaguer; A M Canudas; F X Sureda; E Escubedo; J Camarasa; M Pallàs; A Camins
Journal:  Br J Pharmacol       Date:  2001-02       Impact factor: 8.739

3.  Orphenadrine is an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist: binding and patch clamp studies.

Authors:  J Kornhuber; C G Parsons; S Hartmann; W Retz; S Kamolz; J Thome; P Riederer
Journal:  J Neural Transm Gen Sect       Date:  1995

Review 4.  Clinical pharmacokinetic and pharmacodynamic properties of drugs used in the treatment of Parkinson's disease.

Authors:  Dirk Deleu; Margaret G Northway; Yolande Hanssens
Journal:  Clin Pharmacokinet       Date:  2002       Impact factor: 6.447

5.  Spectrophotometric determination of tizanidine and orphenadrine via ion pair complex formation using eosin Y.

Authors:  Mohamed I Walash; Fathalla F Belal; Manal I Eid; Samah Abo El Abass Mohamed
Journal:  Chem Cent J       Date:  2011-10-08       Impact factor: 4.215
  5 in total

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