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Literature DB >> 35072112

A simplified protocol for performing MAGMA/H-MAGMA gene set analysis utilizing high-performance computing environments.

Abstract

Here, we present a quick-start protocol to perform generalized gene-set analysis of GWAS data on a metaset of gene lists generated by upstream pipelines, such as differential expression analysis, using the Multi-marker Analysis of GenoMic Annotation (MAGMA) software package and Hi-C coupled H-MAGMA annotation data (de Leeuw et al., 2015; Sey et al., 2020). We specifically tailor the steps and operations to meet the multithreading capability in modern computers, a feature nowadays shared by personal computers and high-performance clusters alike. For complete details on the use and execution of this profile, please refer to Yao et al. (2021).

Entities: Chemical

Keywords: Bioinformatics; Genetics; Genomics; Neuroscience

Mesh：

Year: 2022 PMID： 35072112 PMCID： PMC8761752 DOI： 10.1016/j.xpro.2021.101083

Source DB: PubMed Journal: STAR Protoc ISSN： 2666-1667

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References

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A simplified protocol for performing MAGMA/H-MAGMA gene set analysis utilizing high-performance computing environments.

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