Mahdieh-Sadat Moosavi1, Fatemeh Tavakol2. 1. Dental Research Center, Dentistry Research Institute, Department of Oral and Maxillofacial Medicine, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. 2. Department of Oral and Maxillofacial Medicine, School of Dentistry, Lorestan University of Medical Sciences, Khorramabad, Iran.
Abstract
OBJECTIVE: As there is no review study about cancer stem cells (CSCs) involved in the pathogenesis of oral lichen planus (OLP), for the first time we review the role of these cells in OLP and this hypothesis may be a clue for the evaluation of the premalignancy of OLP. BACKGROUND: Cellular mediated immune responses are the main etiopathogenesis in OLP and it is a potentially premalignant lesion. One of the factors proposed in the pathogenesis of OLP and the comparable trend of this autoimmune disease to squamous cell carcinoma (SCC) are CSCs. CSCs have been detected in several solid tumors including head and neck cancers, and have special characteristics including metastasis and resistance to chemotherapy. METHODS: Related keywords were searched and risk of bias assessment was done for each study. CONCLUSIONS: Among all of the studies reviewed in this article, all markers had increased expression in OLP compared to controls that are consistent with SCC. Only CD44 was in contradiction to other papers, in which different expression of CD44 strains was measured in different samples such as saliva and tissue. Based on the results of this review and more studies in the future by investigating the levels of these markers in OLP, it may be possible to determine the prognosis and course of the disease for each patient individually. 2021 Stem Cell Investigation. All rights reserved.
OBJECTIVE: As there is no review study about cancer stem cells (CSCs) involved in the pathogenesis of oral lichen planus (OLP), for the first time we review the role of these cells in OLP and this hypothesis may be a clue for the evaluation of the premalignancy of OLP. BACKGROUND: Cellular mediated immune responses are the main etiopathogenesis in OLP and it is a potentially premalignant lesion. One of the factors proposed in the pathogenesis of OLP and the comparable trend of this autoimmune disease to squamous cell carcinoma (SCC) are CSCs. CSCs have been detected in several solid tumors including head and neck cancers, and have special characteristics including metastasis and resistance to chemotherapy. METHODS: Related keywords were searched and risk of bias assessment was done for each study. CONCLUSIONS: Among all of the studies reviewed in this article, all markers had increased expression in OLP compared to controls that are consistent with SCC. Only CD44 was in contradiction to other papers, in which different expression of CD44 strains was measured in different samples such as saliva and tissue. Based on the results of this review and more studies in the future by investigating the levels of these markers in OLP, it may be possible to determine the prognosis and course of the disease for each patient individually. 2021 Stem Cell Investigation. All rights reserved.
Entities:
Keywords:
Cancer stem cell (CSC); malignancy; oral lichen planus (OLP)
Authors: Andrea Santarelli; Marco Mascitti; Corrado Rubini; Fabrizio Bambini; Antonio Zizzi; Annamaria Offidani; Giulia Ganzetti; Luigi Laino; Marco Cicciù; Lorenzo Lo Muzio Journal: Int J Immunopathol Pharmacol Date: 2015-08-24 Impact factor: 3.219