Patient and Caregiver Preferences for First-Line Treatments of Metastatic Non-Small Cell Lung Cancer: A Discrete Choice Experiment.

PURPOSE: The approval of immune checkpoint inhibitors for metastatic non-small-cell lung carcinomas (mNSCLC) treatment has presented more care options. Therefore, it is important to identify the benefit-risk trade-offs patients and caregivers are willing to make among potential treatment options. This study quantified the preferences of patients and caregivers for attributes of mNSCLC treatment.
METHODS: Patients with mNSCLC and caregivers completed an online survey assessing preferences using a discrete choice experiment. Respondents chose between hypothetical treatment profiles, with varying levels for 7 attributes associated with first-line treatment, including overall survival (OS), progression-free survival, select adverse events (AEs), and regimen (caregivers). Hierarchical Bayesian modeling was used to estimate attribute-level preference weights.
RESULTS: Patients (n = 308) and caregivers (n = 166) most valued increasing OS from 11 to 30 months, followed by decreasing the risk of a serious AE (grade 3/4) that may lead to hospitalization from 70% to 18%. These attributes were over twice as important to both sets of respondents as the other attributes measured. Patients and caregivers would accept increases in the risks of a serious AE (grade 3/4) from 18% to 70% and all grades nausea from 10% to 69% if OS increased by 16.8 and 4.0 months, respectively. The least valued attributes were all grades of pneumonitis (patients) and all grades of skin rash (caregivers).
CONCLUSION: Patients and caregivers are willing to make trade-offs between efficacy and toxicity and may require up to 1.5 years of increased OS to accept a higher risk of AEs. These results can provide guidance to oncologists when engaging in shared-decision making discussions.

Introduction

Lung cancer is associated with tremendous burden for patients and caregivers alike. Despite consistently declining rates over the past decade, it is estimated that this malignancy will account for more than 135,000 deaths and 22% of all cancer-related mortalities in the United States (US) in 2020,1 which is nearly as many as the next most frequent causes of cancer-related deaths due to pancreatic, colorectal and breast, combined.1

The majority of lung cancer diagnoses in the US are non-small-cell lung carcinomas (NSCLC),2 and many patients with NSCLC are diagnosed with advanced disease.1 Patients diagnosed with metastatic NSCLC (mNSCLC) have a poor prognosis, with less than 6% of individuals surviving beyond 5 years.

Traditionally, the first-line treatment for mNSCLC has been platinum-based doublet chemotherapy, with response rates of between 15–30%,3,4 followed by taxane-based chemotherapy regimens as second-line therapy, with response rates of less than 10%.5,6 In the past decade, the treatment landscape for NSCLC has undergone substantial changes, with the introduction of immune checkpoint inhibitors that have demonstrated more durable responses among patients with mNSCLC.7,8

Because of these encouraging results, checkpoint inhibitors have become front-line therapy, with US Food and Drug Administration approval for pembrolizumab and atezolizumab as monotherapy in patients whose tumors have high programmed death-ligand 1 (PD-L1) expression (tumor proportion score [TPS]≥50%; pembrolizumab’s approval was later expanded to include TPS≥1%), as well as combination regimens with pembrolizumab or atezolizumab plus chemotherapy. Additionally, trials evaluating combinations of checkpoint inhibitors, with or without chemotherapy, have had promising results.9,10 This has led to approvals for nivolumab plus ipilimumab, with or without chemotherapy, as another first-line treatment option for patients with mNSCLC.

As new treatment options become available, decision-making among physicians, patients, and their caregivers becomes more complex and challenging. Governing medical bodies and patient advocacy agencies alike have promoted a shared decision-making model in oncology, with previous studies demonstrating the importance of assessing and incorporating patient preferences in treatment planning.11 Such preferences are critical in guiding discussions between providers and patients and their caregivers in the context of mNSCLC.

The burden of informal caregiving in cancer has been widely documented, including in the context of lung cancer.12–16 Caregivers play a critical role in caring for patients, as well as helping guide treatment and care decisions. Despite this, there have been few studies examining caregiver treatment preferences in the context of NSCLC. Critically, those studies that do exist have primarily focused on preferences in the era before the widespread introduction of checkpoint inhibitor agents and exclusively examined patient preferences.17–23

The need for contemporary data that includes the voices of patients and caregivers is particularly notable given the differences in side effect profiles between traditional chemotherapy regimens and newer immune checkpoint inhibitor therapies.24 This study sought to understand the trade-offs that patients and caregivers are willing to make regarding efficacy and toxicities associated with chemotherapy alone, immunotherapy (IO) alone, IO in combination with chemotherapy, and IO in combination with another IO for the first-line treatment of mNSCLC.

Materials and Methods

This was a multi-phase study, including: 1) literature review and concept elicitation interviews to identify key features (attributes) of treatment that affect treatment choice; 2) cognitive interviews to get feedback on the draft quantitative survey, and 3) execution of online, cross-sectional quantitative stated preference surveys to measure preferences among patients and caregivers.

Patients and caregivers were recruited by convenience sampling via referrals from physician sites, cancer advocacy groups, social media outreach, and databases of patients who have opted in to be contacted for scientific studies. For the purposes of this research, participating patients and caregivers may have been, but were not required to have been, associated with one another. Patients and caregivers who participated in the concept elicitation interviews or the cognitive interviews were not included in the quantitative phase of the study.

Patients were included if they had a diagnosis of mNSCLC (stage IV), were aged 18–94 years, and self-reported receiving (past or current) or being scheduled to receive treatment with prescription medications for mNSCLC. A targeted recruitment of 300 patients was undertaken, evenly split between those under 65 years of age and those 65 years or older.

Caregivers were included if they were 18–94 years old, self-reported that they were currently caring for a patient with a diagnosis of mNSCLC (stage IV) between 18–94 years old, the patient they were caring for was receiving/had received or was scheduled to receive treatment with prescription medications for mNSCLC, they were the primary caregiver (mainly responsible or sharing responsibility equally for making treatment decisions and managing finances), did not receive payment as a form of employment for providing care to the patient (unless the patient was a family member), and provided care to the patient for ≥4 hours per week. Quotas were set to recruit 75 caregivers for patients under 65 years old and 75 caregivers for patients 65 years or older.

Patients who reported having an epidermal growth factor receptor (EGFR) or anaplastic large-cell lymphoma kinase (ALK) mutation or having been treated with a tyrosine kinase inhibitor (TKI) were excluded, as were caregivers of patients with either of these mutations or who were treated with a TKI.

As the data from the interview and survey procedures were not linked with personally identifying information (exempt review category DHHS 45 CFR 46.104(d) category 2), this study was determined to be exempt from ethics review by Pearl IRB (Indianapolis, IN; IRB Study Number: 18-KANT-170) prior to starting data collection. This study was conducted in accordance with the Declaration of Helsinki, and informed consent was obtained from all respondents electronically.

Survey Content

Treatment preferences were evaluated using a discrete choice experiment (DCE) designed to estimate respondents’ willingness to accept trade-offs among hypothetical treatment profiles.25 In a series of 12 choice tasks, respondents choose their preferred option among two side-by-side treatment profiles that vary with respect to their attribute levels. Each choice task included 7 attributes with 3–4 levels per attribute for each respondent group. As our qualitative research revealed that patients and caregivers had less awareness of PD-L1 status, attributes and levels were not split by PD-L1 level in the DCEs. The DCEs incorporated a balanced, overlap design.26

Attributes and levels were selected through an iterative, comprehensive process. First, a focused literature review of key clinical trials was undertaken27–41 to help guide the selection of attributes and levels. Concept elicitation interviews with 10 patients and 10 caregivers informed the final selection of attributes in the quantitative survey. Open-ended questions were used to identify factors that were important to patients and caregivers in treatment selection. Patients and caregivers were also probed on key attributes identified in the focused literature review. Survey questions were then designed based on these findings and finalized through cognitive interviews with 8 patients and 8 caregivers. Attributes were worded using non-technical language, including utilizing the Common Terminology Criteria for Adverse Events descriptions for adverse events (AEs).42 The levels selected for each attribute represented the range of performance seen in available therapies or expected for those under investigation, at the time of the study.

The operational definitions of the attributes and levels used in the DCE exercise for patients and caregivers are presented in Table 1. Whereas the DCE for both respondent groups included overall survival (OS), progression-free survival (PFS), risks of a serious AE (grade 3/4) that may lead to hospitalization, nausea, and pneumonitis, some of the attributes differed for the two respondent groups, due to differences identified in the qualitative research. Notably, whereas patients were concerned about the risks of neuropathy and fatigue, caregivers were more concerned about the risk of skin rash, possibly due to the efforts required on their part to treat the skin rash, and dosing schedule, as treatment was demanding and exhausting for the patient.

Table 1

Attributes and Levels Included in the Discrete Choice Experiment

Attribute	Description Shown	Levels Shown to Patients	Levels Shown to Caregivers
Median OS (months)	Survival (life expectancy) of X months	11
		17
		30
Median PFS (months)	Remain stable (cancer does not worsen) for X months	5
		8
		10
Nausea (all grades)	X% risk of nausea affecting appetite, which could lead to dehydration and malnutrition	10% risk
		36% risk
		69% risk
Neuropathy (all grades)	X% risk of neuropathy involving numbness or/and pain, possibly severe, in hands and feet which may limit daily activities	5% risk	(not included in caregiver DCE)
		16% risk
		39% risk
Pneumonitis (all grades)	X% risk of inflammation in the lungs, which could become serious and possibly require temporary medical oxygen	<1% risk
		5% risk
		8% risk
Fatigue (grade 3/4)	X% risk of fatigue that is not relieved by rest and may limit your energy to care for yourself (eg bathing, dressing, feeding self)	1% risk	(not included in caregiver DCE)
		6% risk
		12% risk
Skin rash (all grades)	X% risk of skin rash involving itching and/or burning, which could become severe, limiting daily activities	(not included in patient DCE)	12% risk
			17% risk
			22% risk
Serious (grade 3/4) AE	X% risk of a serious side effect that may lead to hospitalization	18% risk
		48% risk
		70% risk
Regimen		(not included in patient DCE)	4 different regimensa

Notes: Attributes included for only patients or only caregivers reflect differences in the attributes that were identified as most concerning in our prior qualitative research. aRegimens included: (1) 2 to 8 hours of chair time receiving IV therapy every 1 to 3 weeks for 3 to 4 months then 45 to 75 minutes every 3 to 4 weeks; (2) 1 to 2 hours of chair time receiving IV therapy every 3 to 4 weeks for 3 to 4 months then 30 to 60 minutes every 2 to 4 weeks; (3) 1 to 4 hours of chair time receiving IV therapy every 1 to 3 weeks; (4) 30 to 60 minutes of chair time receiving IV therapy every 3 to 4 weeks.

Abbreviations: AE, adverse event; OS, overall survival; PFS, progression-free survival.

This study also collected data on patient and caregiver sociodemographic characteristics, patient health characteristics and treatment history, timing of cost discussions with physicians, and patient and caregiver out-of-pocket costs and financial assistance. A series of rating items were also included, in which respondents rated each attribute level included in the DCE on a 5-point scale (1 = very bad, 5 = very good). These items served two purposes: 1) they helped familiarize respondents to the attributes in the DCE choice exercise; and 2) they aided in identifying respondents who may have been inattentive in their responses.

Statistical Analysis

Descriptive statistics were calculated for all study variables, using means and standard deviations (SDs) for continuous variables and frequencies and percentages for categorical variables.

A hierarchical Bayesian (HB) model, utilizing a conditional logit underlying choice probability model and effects-coded attribute levels, was fitted to the choice data to derive mean preference weights.43 Willingness to make trade-offs was assessed by comparing the magnitude of change between levels of one attribute to the magnitude of change between levels in another attribute. The number of additional months of OS required to offset an increase in the risk of an AE from the lowest to the highest level was calculated for each AE. The conditional relative importance of each attribute was calculated for each respondent based on the difference between the respective minimum and maximum levels. As these relative importance estimates are ratio-scaled, the importance of one attribute can be directly compared to the importance of another attribute (eg, an attribute with a relative importance of 20% is twice as important as an attribute with a relative importance of 10%). Further details on this methodology have been reported elsewhere.44

Bivariate analyses were performed to examine whether the relative importance of attributes differed by select subgroups of respondents using one-way analysis of variance tests. Subgroups examined included patient age (<65 vs 65+ years), caregiver age (<44 years vs 45–54 years vs 55–64 years vs 65+ years), race/ethnicity (African American vs Asian vs Hispanic vs White, patients only), household income (<$50,000 vs $50,000–$99,999 vs $100,000–$149,999 vs $150,000+), employment status (employed vs temporary leave of absence vs not employed vs retired, patients only), future treatment options for NSCLC (on last treatment option vs limited other treatment options vs several other treatment options), and patient insurance status (coverage through employer vs Medicare with Medigap vs Medicare without Medigap, caregivers only). Patients and caregivers were not directly compared, given the different sets of attributes and levels included in the DCE for each stakeholder group.

Data were analyzed using Sawtooth’s Choice-Based Conjoint HB (CBC/HB) Lighthouse Studio software version 9.8.0 for the DCE and using IBM SPSS version 23.0 for descriptive and bivariate statistics.

Results

Of the 349 patients and 217 caregivers who entered the survey, 308 patients and 188 caregivers qualified for and completed the survey. As 38 patients and 22 caregivers were flagged as potentially showing a lack of attention when completing the survey (ie, had 2 or more illogical responses to the attribute rating items, completed the survey in less than half of the median completion time, and/or completed the DCE section in less than 5 seconds per task), the preference weights were examined with and without these data. For patients, none of the preference weights differed significantly between the full sample and the sample without these 38 respondents. However, for caregivers, at least one of the preference weights differed between the full sample and the sample without the 22 caregivers. Therefore, 0 patients and 22 caregivers were excluded from the analysis, yielding final effective sample sizes of 308 patients and 166 caregivers.

The mean patient age was 63.6 years. The majority were married/in a committed relationship (69.5%) and had completed at least some college (85.7%); 35.1% were employed, of which 21.1% were on a temporary leave of absence. Almost three-quarters (71.8%) were undergoing treatment with prescription medication at the time of study. Over one-third (38.3%) of patients did not know their PD-L1 status, and 31.8% reported that their PD-L1 had not been discussed (Table 2).

Table 2

Sample Characteristics

Variable	Patients	Caregivers
	(n=308)	(n=166)
Patient age, years, mean ± SD	63.6 ± 11.7	65.4 ± 12.8
Caregiver age, years, mean ± SD	–	57.6 ± 14.8
Patient gender, male, n (%)	163 (52.9)	89 (53.6)
Caregiver gender, male, n (%)	–	55 (33.1)
Marital status, n (%)
Single/separated/divorced/widowed	94 (30.5)	35 (21.1)
Committed relationship/married	214 (69.5)	131 (78.9)
Education, n (%)
Less than college degree	117 (38.0)	68 (41.0)
College graduate or higher	191 (62.0)	98 (59.0)
Current employment status, n (%)
Employed (full or part time)	43 (14.0)	82 (49.4)
Employed, but currently on temporary leave of absence	65 (21.1)	7 (4.2)
Not employed	42 (13.6)	18 (10.8)
Retired	143 (46.4)	55 (33.1)
Other	15 (4.9)	4 (2.4)
Household income, n (%)
Less than $50,000	71 (23.1)	46 (27.7)
$50,000-$99,999	103 (33.4)	62 (37.3)
$100,000-$149,999	81 (26.3)	27 (16.3)
$150,000+	39 (12.7)	31 (18.7)
Prefer not to answer	14 (4.5)	0 (0)
Patient’s primary health insurance, n (%)
Coverage through own, spouse’s or parent’s employer	140 (45.5)	64 (38.6)
Individual/family insurance plan	35 (11.4)	19 (11.4)
Medicaid/MediCal	14 (4.5)	5 (3.0)
Medicare/Medicare Advantage	114 (37.0)	73 (44.0)
Veteran’s administration/TRICARE	3 (1.0)	3 (1.8)
Not sure/decline to answer	2 (0.6)	2 (1.2)
Race/Ethnicity, n (%)*
African American/Black	39 (12.7)	15 (9.0)
Asian	32 (10.4)	15 (9.0)
American Indian	4 (1.3)	0 (0.0)
Hispanic	56 (18.2)	23 (13.9)
White	183 (59.4)	110 (66.3)
Other	1 (0.3)	3 (1.8)
Region, n (%)
Northeast	16 (5.2)	7 (4.2)
Midwest	28 (9.1)	15 (9.0)
South	39 (12.7)	32 (19.3)
West	225 (73.1)	112 (67.5)
Urban area, n (%)
Major metropolitan/urban area	126 (40.9)	66 (39.8)
Suburb	78 (25.3)	35 (21.1)
Rural/small city	104 (33.8)	65 (39.2)
Duration of NSCLC disease, years, mean ± SD	1.8 ± 1.6	2.0 ± 1.9
Number of treatment regimen changes, n (%)
Never undergone systemic treatment	40 (13.0)	19 (11.4)
Currently on or completed first-line treatment	47 (15.3)	35 (21.1)
Currently on or completed second-line treatment	79 (25.6)	44 (26.5)
Currently on or completed third-line or later treatment	142 (46.1)	68 (41.0)
PD-L1 statusa
High PD-L1	29 (9.4)	18 (10.8)
Low PD-L1	53 (17.2)	20 (12.0)
Do not recall/not sure	118 (38.3)	82 (49.4)
Not discussed	98 (31.8)	41 (24.7)
Future treatment options for mNSCLCb
On last treatment option	65 (21.2)	36 (21.7)
Limited number of treatment options	141 (45.9)	71 (42.8)
Several other treatment options	85 (27.7)	56 (33.7)

Notes: *Total may sum to >100%, as multiple options could be selected for race/ethnicity. aN=10 patients and N=5 caregivers selected “None of the above” to the question about PD-L1 status. bN=16 patients and N=3 caregivers selected “None of the above” to the question about future treatment options.

Abbreviations: mNSCLC, metastatic non-small-cell lung carcinomas; SD, standard deviation.

The mean age for patients being cared for was 65.4 years, and the mean caregiver age was 57.6 years. The majority of caregivers had completed at least some college (86.1%) and over half were employed (53.6%), of which 4.2% were on a leave of absence (constituting nearly 10% of those employed). Most caregivers were patients’ spouses or significant others (65.1%). Nearly three-quarters (72.3%) of patients being cared for were undergoing treatment with prescription medication at the time of study. Almost half (49.4%) of patients being cared for were unaware of their PD-L1 status, with another 24.7% reporting that their PD-L1 status had not been discussed by their physician (Table 2).

Patients reported an average annual out-of-pocket maximum of $2900.37; 30.8% had requested financial assistance for a cancer drug, and over one-third (35.7%) indicated that they had been denied financial assistance. Four in ten patients (40.6%) reported that they did not discuss treatment costs with the physician’s office. Notably, 23.9% of patients rated the cost of cancer drugs as burdensome.

Caregivers reported that patients being cared for had an average annual out-of-pocket maximum of $3156.90; 29.5% had requested financial assistance for a cancer drug, and 28.9% had been denied financial assistance. Almost three-quarters (72.3%) of caregivers helped support the patient financially; Financial burden included costs associated with: traveling for the patient’s medical care (30.1%), unpaid leave from work (25.3%), cancer drugs (18.6%), and other out-of-pocket expenses (50.6%) (Table 3). Approximately one in four caregivers (29.5%) reported that treatment costs were not discussed with the physician’s office, and 15.7% reported being unsure about the timing of any treatment cost discussions.

Table 3

Financial Support and Burden Among Caregivers

Variable	N=166
Help support patient financially, yes, n (%)	120 (72.3)
Burdensome out-of-pocket expenses outside the cost of medication, yes, n (%)
Cost of travel for treatment	50 (30.1)
Unpaid leave from work	42 (25.3)
Lodging/overnight stays	15 (9.0)
Other	84 (50.6)
None	52 (31.3)
Financial burden of out-of-pocket expenses, rating of 4 or 5, n (%)
Cost of cancer drugs	31 (18.7)
Cost of travel for treatment	14 (28.0)
Unpaid leave from work	24 (57.1)
Lodging/overnight stays	8 (53.3)

Notes: Rating of financial burden of cost of cancer drugs, travel, lodging/overnight stays, and unpaid leave from work were rated on a scale from 1=Not at all a burden to 5=A great burden.

Preference Findings

Patient and caregiver DCE results are shown in Figures 1 and 2, respectively. Improving median OS from 11 to 30 months was the most important attribute to patients and caregivers, followed by decreasing the risk of a serious AE (grade 3/4) that may lead to hospitalization from 70% to 18%. Improvements in these attributes were over two times more important than improvements in each of the other attributes measured. Additionally, caregivers placed importance on a treatment regimen with shorter administration time and lower dosing frequency. Least important was decreasing the risk of all grades of pneumonitis from 8% to <1% among patients and decreasing the risk of all grades of skin rash from 22% to 12% among caregivers (Figures 1A and 2A).

Figure 1

Patient preferences: (A) relative importance of treatment attributes, (B) attribute-level preference weights, and (C) increases in number of OS months needed to accept increases in toxicity levels.

Figure 2

Caregiver preferences: (A) relative importance of treatment attributes, (B) attribute-level preference weights, and (C) increases in number of OS months needed to accept increases in toxicity levels.

The differences among attribute-level preference weights demonstrate how much they are valued and show the trade-offs individuals are willing to make. For example, among patients, an increase in OS from 17 months to 30 months (−0.65–[3.73]=−4.38) outweighed the reduction in risk of all grades nausea from 69% to 36% (0.22–[−0.79]=1.01) in importance for patients (Figure 1B). Among caregivers, an increase in OS from 11 months to 17 months (−2.74–[−0.23]=−2.51) outweighed the reduction in risk from 8% to 5% in pneumonitis (0.03–[−0.07]=0.10) in importance (Figure 2B). A 6-month gain in OS (from 11 to 17 months) outweighed a 5-month increase in PFS (from 5 to 10 months) for both patients (−2.43 vs −0.88) and caregivers (−2.51 vs −1.01).

Both patients and caregivers would require median OS improvements of 16.8 and 4.0 months to accept an increase in risks of a serious AE (grade 3/4) that may lead to hospitalization from 18% to 70% and all grades nausea from 10% to 69%, respectively (Figures 1C and 2C).

Bivariate Analysis Results

Statistically significant differences in the relative importance of reducing the risk of a serious AE (grade 3/4) that may lead to hospitalization from 70% to 18% were identified by patient employment status and future treatment options for NSCLC. Regarding employment status, reducing the risk of a serious AE (grade 3/4) that may lead to hospitalization from 70% to 18% was more important to employed patients than to patients on a temporary leave of absence or retired patients (38.1% vs 30.1% and 29.9%, respectively, P=0.031), but no different than unemployed patients (35.4%). As such, employed patients require a greater increase in median OS to offset the increase in risk of a serious AE (grade 3/4) that may lead to hospitalization from 18% to 70% than patients on a temporary leave of absence, unemployed patients, or retired patients (25.1 vs 14.3 and 16.7 and 13.5 months, respectively; see ).

With respect to future treatment options, reducing the risk of a serious AE (grade 3/4) that may lead to hospitalization from 70% to 18% was more important to patients who felt there were limited or several other treatment options available, compared with patients on their last treatment option (32.4% and 35.3% vs 26.3%, respectively, P=0.010), and was more important to caregivers of patients with limited other treatment options, compared with caregivers of patients on their last treatment option or with several other treatment options (29.8% vs 19.9% and 23.1%, respectively, P=0.006).

In addition, with the exception of all grades nausea, patients who perceived having several other treatment options required the greatest increases in OS to accept the increased risk of toxicities compared to those who perceived they had limited other treatment options or that they were on their last treatment option. Caregivers who perceived that the patient they cared for had limited other treatment options required the greatest increases in OS to accept the increased risk of toxicities. Nevertheless, patients and caregivers required the largest increase in number of OS months to accept a risk of a serious AE (grade 3/4) that may lead to hospitalization (from 18% to 70%) than any other toxicity, regardless of the quantity of remaining treatment options perceived ().

Patient age, caregiver age, patient race/ethnicity, household income, and patient insurance status generally did not affect treatment preferences.

Discussion

This study helps to fill the gap in the literature on the treatment preferences of patients and caregivers in first-line mNSCLC given the newly available treatments in this space. Overall, this study found that patients and caregivers were both willing to accept increases in toxicity risks, within the ranges evaluated, in exchange for improvements in efficacy. Notably, improved OS was the most important attribute for both groups. Patients and caregivers both reported a willingness to make trade-offs between efficacy and toxicities when selecting a treatment. Specifically, this study demonstrated that to accept a higher risk of toxicities, patients and caregivers may require an increase in OS of up to a year and a half.

The current study found that among patients, increasing OS from 11 to 30 months was most important, followed by decreasing the risk of a serious AE (grade 3/4) that may lead to hospitalization from 70% to 18%. These attributes were over three times more important than increasing PFS from 5 to 9 months and reducing the risks of grade 3/4 fatigue from 12% to 1%, and all grades nausea from 69% to 10%, neuropathy from 39% to 5%, and pneumonitis from 8% to 1%. The same two attributes, OS and the risk of a serious AE that may lead to hospitalization, were also the most important among caregivers and more than twice as important as increasing PFS from 5 to 9 months, reducing the risks of all grades nausea from 69% to 10%, pneumonitis from 8% to 1%, and skin rash from 22% to 12%, and reducing the administration time and dosing frequency of treatment among this respondent group.

The consistent preference for survival benefit among both study groups reflects previous work in this domain, with Girones et al reporting that nearly half of their elderly respondents with lung cancer were willing to risk severe side effects, hospitalization, or death for a treatment that possessed the greatest chance of survival.20 Sun et al similarly reported the high importance of treatment efficacy among a cohort of patients with lung cancer; however, they noted the role of side effects, mode of administration, and treatment cost in guiding preferences,22 with further studies highlighting the complexity of preferences in relation to disease symptomatology.23 In addition, one of the few studies that have examined stakeholder preferences in the post-chemotherapy era reported that, although PFS was the most important treatment factor among patients with EGFR positive tumors, they would accept reduced PFS with TKIs in order to gain more favorable side effects and more convenient dosing.45

Notably, employed patients were less likely to choose a treatment with a high risk of a serious AE (grade 3/4) that may lead to hospitalization, compared with patients who were on a temporary leave of absence or retired. Indeed, employed patients required approximately 10 more months in OS to accept an increase in the risk of a serious AE (grade 3/4) that may lead to hospitalization from 18% to 70% than patients who were on a temporary leave of absence, unemployed, or retired. While it is important to note that many employed patients (approximately two-thirds) were not working at the time of the survey, possibly due to treatment, these results suggest that employment status can be an important driver of treatment preference.

This finding is in contrast with a previous study among those receiving treatment for recurrent ovarian cancer, which did not find employment status to be a driver of patient preferences.46 However, Jagsi et al found that among women diagnosed with breast cancer, those who were employed and undergoing aggressive treatment reported significant interference in their professional role.47 Thus, employed patients may possess significant concern of missing time from work should they be hospitalized, especially given that, for many individuals in the US, health insurance is provided through their employer.

Among both respondent groups, preferences also differed based on perceived future treatment options for mNSCLC. Those individuals who perceived that there were additional treatment options were less likely to choose a treatment with a high risk of a serious AE (grade 3/4) that may lead to hospitalization, compared with those who perceived there to be no further treatment options. This suggests that, if there are several available treatment options, then patients and caregivers will minimize their risk of serious side effects. Notably however, as these options become more limited, both patients and caregivers are more willing to assume such risks. These findings provide insight into the many factors that can influence treatment preferences and the importance of shared decision-making with each patient.

The current study also found that treatment for mNSCLC poses a significant economic burden for caregivers in terms of both direct and indirect (eg, unpaid leave) costs. Further, maintaining insurance coverage appeared to be important to caregivers, as suggested by the nearly 10% of employed caregivers who were taking a leave of absence.

Finally, in the current study, over 40% of patients reported not discussing treatment costs with their oncologist, and 45% of caregivers either reported that treatment costs discussions did not occur or could not recall the timing of these conversation, which could imply that treatment costs were not discussed with caregivers. This finding contrasts with a previous study of oncologists where only 24% of oncologists noted that treatment costs were not discussed (manuscript in preparation). This disconnect is critical, given the escalating costs of oncology care and therapeutics, and emphasizes the need for more formal and systematic ways by which costs are addressed during medical visits.

The current study has limitations that should be acknowledged. Due to targeting a 50/50 split of patients under 65 years old and 65 years or older in both respondent groups, our sample over-represented patients under age 65. As the median age of patients in the current study was less than the median age of diagnosis in NSCLC of 71,48 the results may not be generalizable to the entire mNSCLC population. Since the DCE methodology involves choosing between hypothetical treatment profiles based on a finite number of treatment attributes, an additional limitation is that actual treatment choices may differ from stated preferences. To mitigate this bias, qualitative research was conducted to include the attributes of most importance to patients and caregivers when making treatment decisions. Whereas attribute levels were developed based on available clinical evidence at the time of the study, it is possible that other attributes may exist or have become more prominent among the groups surveyed since this time. Finally, while the economic burden of treatment for mNSCLC is important for patients and caregivers, the current study was not designed to examine the impact of OOP costs on treatment preferences. Therefore, future research is needed to understand how economic burden plays a role in treatment preferences.

Conclusion

This study provides key insights into the trade-offs that patients and caregivers are willing to make between efficacy and toxicities in the context of currently available therapies for mNSCLC. The study demonstrated that, to accept a higher risk of toxicities, patients and caregivers required an increase in OS of up to 1.5 years, highlighting the importance of treatment efficacy in treatment decision-making among both groups.

The eliciting of patient and caregiver preferences remains an integral part of compassionate, comprehensive, patient-centered cancer care. Accordingly, the results of this novel study can help guide effective discussions between oncologists and patients/caregivers regarding treatments for mNSCLC.