Premashis Kar1, Bhabadev Goswami2, Jagdish Mahanta3, Thngam Bhimo4, Anup K Das5, Manab Deka6, Kyrshanlang G Lynrah7, Mool R Kotwal8, Pradip Bhaumik9, Moji Jini10, Rahul Karna1, Vijay K Karra11, Harpreet Kaur11. 1. Maulana Azad Medical College, University of Delhi, New Delhi, India. 2. Department of Gastroenterology, Gauhati Medical College, Guwahati, Assam, India. 3. Regional Medical Research Centre, Dibrugarh, Assam, India. 4. Department of Medicine, Regional Institute of Medical Sciences, Regional Medical College, Imphal, Manipur, India. 5. Department of Medicine, Assam Medical College, Dibrugarh, Assam, India. 6. Department of Biotechnology, Gauhati University, Assam, India. 7. Department of Medicine, NEIGRIHMS, Shillong, Meghalaya, India. 8. STNM Hospital, Gangtok, Sikkim, India. 9. Department of Medicine, Agartala Govt. Medical College, Agartala, Tripura, India. 10. General Hospital, Naharlagun, Arunachal Pradesh, India. 11. Division of Epidemiology and Communicable Diseases, Indian Council of Medical Research, Department of Health Research, New Delhi, India.
Abstract
BACKGROUND/ OBJECTIVE: Hepatitis B virus (HBV) infection is a major public health problem globally. Northeast India is home to indigenous tribes with different ethnicity and high rates of drug abuse and HIV infection. The study was designed to estimate the burden of HBV infection across various spectrums of liver diseases from this region. HBV genotypes and subgenotypes play a role in the chronicity of disease, response to treatment and its progression. As very limited data are available from this region, we tried to elucidate the role of HBV genotypes, HBV mutants and their phylogenetic analysis. METHOD: We designed a prospective multicentric study, and included 7464 liver disease cases, 7432 blood donors and 650 health care workers, who were screened for HBV infection. HBV DNA positive patients were genotyped and subjected to surface protein, precore and core mutation and phylogenetic analysis. RESULTS: The prevalence of HBV infection with respect to different types of liver diseases, blood donors and health care workers was 9.9% (1550/15,546). 49.5% (768/1550) cases were found to be HBV DNA positive. The most common genotype was found to be genotype D 74.2% (570/768), followed by genotype C 6.5% (50/768), A 4.4% (34/768) and I 0.9% (7/768). CONCLUSION: This study highlights the high hepatitis B burden in Northeast India, reflecting lacunae in health care needs of the region. Also, the different genotype distribution and presence of mutations may translate into different rates of liver disease progression, prognosis and ultimately, clinical significance. However, further prospective cohort study from Northeast India is warranted, to elucidate the clinical significance of multiple genotypes and mutation in this unique population.
BACKGROUND/ OBJECTIVE: Hepatitis B virus (HBV) infection is a major public health problem globally. Northeast India is home to indigenous tribes with different ethnicity and high rates of drug abuse and HIV infection. The study was designed to estimate the burden of HBV infection across various spectrums of liver diseases from this region. HBV genotypes and subgenotypes play a role in the chronicity of disease, response to treatment and its progression. As very limited data are available from this region, we tried to elucidate the role of HBV genotypes, HBV mutants and their phylogenetic analysis. METHOD: We designed a prospective multicentric study, and included 7464 liver disease cases, 7432 blood donors and 650 health care workers, who were screened for HBV infection. HBV DNA positive patients were genotyped and subjected to surface protein, precore and core mutation and phylogenetic analysis. RESULTS: The prevalence of HBV infection with respect to different types of liver diseases, blood donors and health care workers was 9.9% (1550/15,546). 49.5% (768/1550) cases were found to be HBV DNA positive. The most common genotype was found to be genotype D 74.2% (570/768), followed by genotype C 6.5% (50/768), A 4.4% (34/768) and I 0.9% (7/768). CONCLUSION: This study highlights the high hepatitis B burden in Northeast India, reflecting lacunae in health care needs of the region. Also, the different genotype distribution and presence of mutations may translate into different rates of liver disease progression, prognosis and ultimately, clinical significance. However, further prospective cohort study from Northeast India is warranted, to elucidate the clinical significance of multiple genotypes and mutation in this unique population.
Authors: E Orito; M Mizokami; H Sakugawa; K Michitaka; K Ishikawa; T Ichida; T Okanoue; H Yotsuyanagi; S Iino Journal: Hepatology Date: 2001-01 Impact factor: 17.425