BACKGROUND: It has been hypothesized that medial temporal sparing may be related to preserved posterior cingulate metabolism and the cingulate island sign (CIS) on [18F]fluorodeoxyglucose (FDG) PET in posterior cortical atrophy (PCA). OBJECTIVE: To assess the severity of medial temporal atrophy in PCA and determine whether the presence of a CIS is related to medial temporal sparing. METHODS: Fifty-five PCA patients underwent MRI and FDG-PET. The degree and symmetry of medial temporal atrophy on MRI was visually assessed using a five-point scale for both hemispheres. Visual assessments of FDG-PET coded the presence/absence of a CIS and whether the CIS was symmetric or asymmetric. Hippocampal volumes and a quantitative CIS were also measured. RESULTS: Medial temporal atrophy was most commonly mild or moderate, was symmetric in 55% of patients, and when asymmetric was most commonly worse on the right (76%). Older age and worse memory performance were associated with greater medial temporal atrophy. The CIS was observed in 44% of the PCA patients and was asymmetric in 50% of these. The patients with a CIS showed greater medial temporal asymmetry, but did not show lower medial temporal atrophy scores, compared to those without a CIS. Hippocampal volumes were not associated with quantitative CIS. CONCLUSION: Mild medial temporal atrophy is a common finding in PCA and is associated with memory impairment. However, medial temporal sparing was not related to the presence of a CIS in PCA.
BACKGROUND: It has been hypothesized that medial temporal sparing may be related to preserved posterior cingulate metabolism and the cingulate island sign (CIS) on [18F]fluorodeoxyglucose (FDG) PET in posterior cortical atrophy (PCA). OBJECTIVE: To assess the severity of medial temporal atrophy in PCA and determine whether the presence of a CIS is related to medial temporal sparing. METHODS: Fifty-five PCA patients underwent MRI and FDG-PET. The degree and symmetry of medial temporal atrophy on MRI was visually assessed using a five-point scale for both hemispheres. Visual assessments of FDG-PET coded the presence/absence of a CIS and whether the CIS was symmetric or asymmetric. Hippocampal volumes and a quantitative CIS were also measured. RESULTS: Medial temporal atrophy was most commonly mild or moderate, was symmetric in 55% of patients, and when asymmetric was most commonly worse on the right (76%). Older age and worse memory performance were associated with greater medial temporal atrophy. The CIS was observed in 44% of the PCA patients and was asymmetric in 50% of these. The patients with a CIS showed greater medial temporal asymmetry, but did not show lower medial temporal atrophy scores, compared to those without a CIS. Hippocampal volumes were not associated with quantitative CIS. CONCLUSION: Mild medial temporal atrophy is a common finding in PCA and is associated with memory impairment. However, medial temporal sparing was not related to the presence of a CIS in PCA.
Entities:
Keywords:
Cingulate island sign; FDG-PET; MRI; hippocampus; visual assessmentzzm321990
Authors: Jennifer L Whitwell; Clifford R Jack; Kejal Kantarci; Stephen D Weigand; Bradley F Boeve; David S Knopman; Daniel A Drubach; David F Tang-Wai; Ronald C Petersen; Keith A Josephs Journal: Neurobiol Aging Date: 2006-06-23 Impact factor: 4.673
Authors: Ziad S Nasreddine; Natalie A Phillips; Valérie Bédirian; Simon Charbonneau; Victor Whitehead; Isabelle Collin; Jeffrey L Cummings; Howard Chertkow Journal: J Am Geriatr Soc Date: 2005-04 Impact factor: 5.562
Authors: Musa Gabere; Nha Trang Thu Pham; Jonathan Graff-Radford; Mary M Machulda; Joseph R Duffy; Keith A Josephs; Jennifer L Whitwell Journal: J Alzheimers Dis Date: 2020 Impact factor: 4.472
Authors: Irene Sintini; Christopher G Schwarz; Peter R Martin; Jonathan Graff-Radford; Mary M Machulda; Matthew L Senjem; Robert I Reid; Anthony J Spychalla; Daniel A Drubach; Val J Lowe; Clifford R Jack; Keith A Josephs; Jennifer L Whitwell Journal: Hum Brain Mapp Date: 2018-12-13 Impact factor: 5.038
Authors: G B Frisoni; C Testa; F Sabattoli; A Beltramello; H Soininen; M P Laakso Journal: J Neurol Neurosurg Psychiatry Date: 2005-01 Impact factor: 10.154
Authors: Seok Ming Lim; Andrew Katsifis; Victor L Villemagne; Rene Best; Gareth Jones; Michael Saling; Jennifer Bradshaw; John Merory; Michael Woodward; Malcolm Hopwood; Christopher C Rowe Journal: J Nucl Med Date: 2009-09-16 Impact factor: 10.057
Authors: Christopher G Goetz; Barbara C Tilley; Stephanie R Shaftman; Glenn T Stebbins; Stanley Fahn; Pablo Martinez-Martin; Werner Poewe; Cristina Sampaio; Matthew B Stern; Richard Dodel; Bruno Dubois; Robert Holloway; Joseph Jankovic; Jaime Kulisevsky; Anthony E Lang; Andrew Lees; Sue Leurgans; Peter A LeWitt; David Nyenhuis; C Warren Olanow; Olivier Rascol; Anette Schrag; Jeanne A Teresi; Jacobus J van Hilten; Nancy LaPelle Journal: Mov Disord Date: 2008-11-15 Impact factor: 10.338
Authors: Tarun D Singh; Keith A Josephs; Mary M Machulda; Daniel A Drubach; Liana G Apostolova; Val J Lowe; Jennifer L Whitwell Journal: J Neurol Date: 2015-04-11 Impact factor: 4.849
Authors: Alissa M Butts; Mary M Machulda; Peter Martin; Scott A Przybelski; Joseph R Duffy; Jonathan Graff-Radford; David S Knopman; Ronald C Petersen; Clifford R Jack; Val J Lowe; Keith A Josephs; Jennifer L Whitwell Journal: J Alzheimers Dis Rep Date: 2022-08-05