Ryota Hamada1,2, Tadakazu Kondo3, Kazuhiro Harada4, Masanobu Murao5,4, Junsuke Miyasaka5, Michiko Yoshida5, Honami Yonezawa5, Manabu Nankaku5, Yasuyuki Arai3,6, Junya Kanda3, Akifumi Takaori-Kondo3, Ryosuke Ikeguchi5, Shuichi Matsuda5. 1. Rehabilitation Unit, Kyoto University Hospital, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan. e1923126@kuhp.kyoto-u.ac.jp. 2. Department of Physical Therapy, Graduate School of Health Science, Kibi International University, Okayama, Japan. e1923126@kuhp.kyoto-u.ac.jp. 3. Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. 4. Department of Physical Therapy, Graduate School of Health Science, Kibi International University, Okayama, Japan. 5. Rehabilitation Unit, Kyoto University Hospital, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan. 6. Department of Clinical Laboratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Abstract
PURPOSE: Decline in physical function in the early stage after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a major challenge. Exercise tolerance tests, such as the 6-min walk test, are useful markers for predicting exercise tolerance and various other traits, including cardiometabolic risk and non-relapse mortality. This retrospective cohort study aimed to investigate and identify predictors of recovery of exercise tolerance in the early stage after allo-HSCT. METHODS: Ninety-eight patients were classified into recovery and non-recovery groups according to the median 6-min walk distance (6MWD) at discharge. RESULTS: Logistic regression analysis revealed that pre-post change in knee extensor strength (ΔKES) and hematopoietic cell transplantation comorbidity index were useful predictors of recovery of exercise tolerance at discharge and moderate predictors of 6MWD recovery in the early post-transplant period. Receiver operating characteristic analysis showed that pre-transplant ΔKES was an accurate predictor of 6MWD recovery in the early post-transplant period. The cutoff point for ΔKES calculated using the Youden index was - 1.17 Nm/kg. CONCLUSIONS: The results of this study emphasize the importance of the need for programs designed to prevent muscle weakness in the early period after allo-HSCT. The results from markers of recovery of exercise tolerance are promising and can be used for patient education in rehabilitation programs after allo-HSCT.
PURPOSE: Decline in physical function in the early stage after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a major challenge. Exercise tolerance tests, such as the 6-min walk test, are useful markers for predicting exercise tolerance and various other traits, including cardiometabolic risk and non-relapse mortality. This retrospective cohort study aimed to investigate and identify predictors of recovery of exercise tolerance in the early stage after allo-HSCT. METHODS: Ninety-eight patients were classified into recovery and non-recovery groups according to the median 6-min walk distance (6MWD) at discharge. RESULTS: Logistic regression analysis revealed that pre-post change in knee extensor strength (ΔKES) and hematopoietic cell transplantation comorbidity index were useful predictors of recovery of exercise tolerance at discharge and moderate predictors of 6MWD recovery in the early post-transplant period. Receiver operating characteristic analysis showed that pre-transplant ΔKES was an accurate predictor of 6MWD recovery in the early post-transplant period. The cutoff point for ΔKES calculated using the Youden index was - 1.17 Nm/kg. CONCLUSIONS: The results of this study emphasize the importance of the need for programs designed to prevent muscle weakness in the early period after allo-HSCT. The results from markers of recovery of exercise tolerance are promising and can be used for patient education in rehabilitation programs after allo-HSCT.
Authors: Jerry Tran; Emily E Norder; Philip T Diaz; Gary S Phillips; Pat Elder; Steven M Devine; Karen L Wood Journal: Biol Blood Marrow Transplant Date: 2012-01-30 Impact factor: 5.742
Authors: Megan E Slater; Julia Steinberger; Julie A Ross; Aaron S Kelly; Eric J Chow; Ildiko H Koves; Paul Hoffmeister; Alan R Sinaiko; Anna Petryk; Antoinette Moran; Jill Lee; Lisa S Chow; K Scott Baker Journal: Biol Blood Marrow Transplant Date: 2015-04-10 Impact factor: 5.742
Authors: Sascha A Tuchman; Amy Lane; Whitney E Hornsby; Caroline Bishop; Samantha Thomas; James E Herndon; Gwynn Long; Cristina Gasparetto; Lee W Jones Journal: Clin Lymphoma Myeloma Leuk Date: 2014-09-28
Authors: Inge E P M van Haren; Hans Timmerman; Carin M Potting; Nicole M A Blijlevens; J Bart Staal; Maria W G Nijhuis-van der Sanden Journal: Phys Ther Date: 2012-12-06