Behrang Mahjani1,2,3,4, Christina Gustavsson Mahjani1,3, Abraham Reichenberg1,3,5, Sven Sandin1,3,4, Christina M Hultman4, Joseph D Buxbaum1,3,5,6,7,8, Dorothy E Grice9,10,11,12,13. 1. Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 2. Division of Tics, OCD and Related Disorders, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 3. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1230, New York, NY, 10029, USA. 4. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. 5. The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 6. Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 7. Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 8. Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 9. Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Dorothy.Grice@mssm.edu. 10. Division of Tics, OCD and Related Disorders, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Dorothy.Grice@mssm.edu. 11. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1230, New York, NY, 10029, USA. Dorothy.Grice@mssm.edu. 12. The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Dorothy.Grice@mssm.edu. 13. Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Dorothy.Grice@mssm.edu.
Abstract
PURPOSE: EGOS is an epidemiological obsessive-compulsive disorder (OCD) cohort in Sweden. Individuals contributed DNA for genotyping and sequencing and completed a Swedish translation of the Obsessive-Compulsive Inventory-Revised (OCI-R), a self-report questionnaire for assessing the severity of OCD. This study aimed first to evaluate the psychometric properties of the Swedish translation of the OCI-R and then shed light on the frequency, severity, and symptom dimensions of OCD comorbid with other psychiatric disorders. METHODS: OCI-R data were available for 1010 individuals diagnosed with OCD, and 124 individuals diagnosed with chronic tic disorders without OCD used as a comparison group. We first performed a confirmatory factor analysis to confirm the six-factor structure of OCI-R. Then, we estimated Cronbach's α coefficient and the generalizability coefficient to evaluate the internal consistency of the OCI-R. We linked the data from the Swedish national registries to access and analyze psychiatric comorbidities of OCD. RESULTS: The Swedish translation of OCI-R demonstrated internal consistency and clear agreement with the OCI-R six-factor model. The mean total OCI-R score for females was significantly higher than for males. The most comorbid psychiatric condition to OCD were anxiety disorders (13.6%) and major depression (12%). CONCLUSION: The Swedish translation of OCI-R was a valid and reliable measure for assessing the severity of OCD. We observed that individuals with OCD frequently had additional comorbid psychiatric disorders and that the severity of OCD was significantly higher in individuals with at least one additional psychiatric comorbidity as compared to individuals with no psychiatric comorbidity.
PURPOSE: EGOS is an epidemiological obsessive-compulsive disorder (OCD) cohort in Sweden. Individuals contributed DNA for genotyping and sequencing and completed a Swedish translation of the Obsessive-Compulsive Inventory-Revised (OCI-R), a self-report questionnaire for assessing the severity of OCD. This study aimed first to evaluate the psychometric properties of the Swedish translation of the OCI-R and then shed light on the frequency, severity, and symptom dimensions of OCD comorbid with other psychiatric disorders. METHODS: OCI-R data were available for 1010 individuals diagnosed with OCD, and 124 individuals diagnosed with chronic tic disorders without OCD used as a comparison group. We first performed a confirmatory factor analysis to confirm the six-factor structure of OCI-R. Then, we estimated Cronbach's α coefficient and the generalizability coefficient to evaluate the internal consistency of the OCI-R. We linked the data from the Swedish national registries to access and analyze psychiatric comorbidities of OCD. RESULTS: The Swedish translation of OCI-R demonstrated internal consistency and clear agreement with the OCI-R six-factor model. The mean total OCI-R score for females was significantly higher than for males. The most comorbid psychiatric condition to OCD were anxiety disorders (13.6%) and major depression (12%). CONCLUSION: The Swedish translation of OCI-R was a valid and reliable measure for assessing the severity of OCD. We observed that individuals with OCD frequently had additional comorbid psychiatric disorders and that the severity of OCD was significantly higher in individuals with at least one additional psychiatric comorbidity as compared to individuals with no psychiatric comorbidity.
Authors: Behrang Mahjani; Lambertus Klei; Christina M Hultman; Henrik Larsson; Bernie Devlin; Joseph D Buxbaum; Sven Sandin; Dorothy E Grice Journal: Biol Psychiatry Date: 2020-01-22 Impact factor: 13.382
Authors: Kristen Grabill; Lisa Merlo; Danny Duke; Kelli-Lee Harford; Mary L Keeley; Gary R Geffken; Eric A Storch Journal: J Anxiety Disord Date: 2007-02-03
Authors: M M Weissman; R C Bland; G J Canino; S Greenwald; H G Hwu; C K Lee; S C Newman; M A Oakley-Browne; M Rubio-Stipec; P J Wickramaratne Journal: J Clin Psychiatry Date: 1994-03 Impact factor: 4.384
Authors: Edna B Foa; Jonathan D Huppert; Susanne Leiberg; Robert Langner; Rafael Kichic; Greg Hajcak; Paul M Salkovskis Journal: Psychol Assess Date: 2002-12