Shunsuke Goto1, Hideyo Oguchi2, Ken Sakai2, Tetsuo Mikami3, Daisuke Ichikawa4, Masahiko Yazawa4, Junki Koike5, Kengo Furuichi6, Masahiko Kawabata7, Hitoshi Yokoyama6, Tadashi Sofue8, Emi Ibuki9, Shinichi Nishi10. 1. Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan. sgoto@med.kobe-u.ac.jp. 2. Department of Nephrology, Faculty of Medicine, Toho University, Tokyo, Japan. 3. Department of Pathology, Faculty of Medicine, Toho University, Tokyo, Japan. 4. Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan. 5. Department of Diagnostic Pathology, St. Marianna University School of Medicine, Kawasaki, Japan. 6. Department of Nephrology, Kanazawa Medical University School of Medicine, Uchinada, Japan. 7. Department of Internal Medicine, Toyama Prefectural Central Hospital, Toyama, Japan. 8. Division of Nephrology and Dialysis, Department of Cardiorenal and Cerebrovascular Medicine, Kagawa University, Kagawa, Japan. 9. Department of Diagnostic Pathology, Kagawa University, Kagawa, Japan. 10. Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Abstract
BACKGROUND: There are certain criteria for selecting living kidney donors. However, the association between clinical characteristics of these criteria and kidney biopsy findings in living kidney donors have not yet been elucidated. Thus, we investigated the association between kidney biopsy findings and clinical characteristics defined in the Japanese guidelines for living kidney donors. METHODS: A retrospective multicentre study was conducted on donors and their recipients who underwent kidney transplantation between July 2014 and June 2017. Multiple linear regression analysis and multiple logistic regression analysis were performed to investigate the association between biopsy findings and clinical characteristics. RESULTS: A total of 240 donors and 240 recipients were included. Age was significantly correlated with global glomerulosclerosis and intimal thickening in multiple linear regression analysis and multiple logistic regression analysis, whereas diabetes was correlated with tubular atrophy in multiple linear regression analysis after multiple imputation and multiple logistic regression analysis. CONCLUSIONS: Amongst the clinical factors investigated in our study, age was positively correlated and diabetes was possibly correlated with kidney tissue injury in living kidney donors. Age and diabetes may be more important for selecting suitable living kidney donors than other clinical factors.
BACKGROUND: There are certain criteria for selecting living kidney donors. However, the association between clinical characteristics of these criteria and kidney biopsy findings in living kidney donors have not yet been elucidated. Thus, we investigated the association between kidney biopsy findings and clinical characteristics defined in the Japanese guidelines for living kidney donors. METHODS: A retrospective multicentre study was conducted on donors and their recipients who underwent kidney transplantation between July 2014 and June 2017. Multiple linear regression analysis and multiple logistic regression analysis were performed to investigate the association between biopsy findings and clinical characteristics. RESULTS: A total of 240 donors and 240 recipients were included. Age was significantly correlated with global glomerulosclerosis and intimal thickening in multiple linear regression analysis and multiple logistic regression analysis, whereas diabetes was correlated with tubular atrophy in multiple linear regression analysis after multiple imputation and multiple logistic regression analysis. CONCLUSIONS: Amongst the clinical factors investigated in our study, age was positively correlated and diabetes was possibly correlated with kidney tissue injury in living kidney donors. Age and diabetes may be more important for selecting suitable living kidney donors than other clinical factors.
Authors: Naim Issa; Lisa E Vaughan; Aleksandar Denic; Walter K Kremers; Harini A Chakkera; Walter D Park; Arthur J Matas; Sandra J Taler; Mark D Stegall; Joshua J Augustine; Andrew D Rule Journal: Am J Transplant Date: 2019-02-01 Impact factor: 8.086