| Literature DB >> 35061167 |
Naoki Iwasa1,2, Satoshi Takashima2, Tatsuo Iwasa1, Rie Kumazawa1, Saki Nomura2, Sara Asami2, Mamu Shimizu2, Yui Kobatake2, Naohito Nishii3.
Abstract
This study investigated the effects of age, sex and breed on serum cystatin C (Cys-C) and creatinine in small breed dogs. This retrospective study included 250 dogs weighing less than 15 kg without azotemia. Serum Cys-C and creatinine concentrations were analyzed, along with their correlation with age, and the difference between sexes or dog breeds. Serum Cys-C concentration correlated with age (P < 0.001), and did not differ between sexes or dog breeds. By contrast, serum creatinine concentration did not correlate with age. Serum creatinine concentration was higher in males than females (P < 0.05), and was lower in Miniature Dachshunds and Chihuahuas, and was higher in Shiba Inus compared to the general study population (P < 0.001). Serum Cys-C concentration correlates with age, and might be more sensitive to aging-associated subclinical renal dysfunction than serum creatinine concentration in dogs. Unlike serum creatinine concentration, serum Cys-C concentration is not affected by sex or dog breed.Entities:
Keywords: Age; Creatinine; Cystatin C; Dog breed; Sex
Mesh：
Substances：
Year: 2022 PMID： 35061167 DOI： 10.1007/s11259-021-09844-w
Source DB: PubMed Journal: Vet Res Commun ISSN： 0165-7380 Impact factor: 2.459