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Literature DB >> 35059112

Antivirals against (Re)emerging Flaviviruses: Should We Target the Virus or the Host?

María-Jesús Pérez-Pérez¹, Juan-Carlos Saiz², Eva-María Priego¹, Miguel A Martín-Acebes².

Abstract

The COVID pandemic has evidenced how vulnerable we are to emerging infectious diseases and how short our current armamentarium is. Flavivirus, single stranded RNA viruses transmitted by arthropods, are considered a global health challenge. No drugs to treat these infections have been approved. In this Viewpoint, we analyze the advantages and disadvantages of two different, but probably also complementary, therapeutic approaches: virus-targeting antivirals and host-targeting drugs.

Entities: Chemical

Year: 2021 PMID： 35059112 PMCID： PMC8762743 DOI： 10.1021/acsmedchemlett.1c00617

Source DB: PubMed Journal: ACS Med Chem Lett ISSN： 1948-5875 Impact factor: 4.345

36 in total

Review 1. The continued threat of emerging flaviviruses.

Authors: Theodore C Pierson; Michael S Diamond
Journal: Nat Microbiol Date: 2020-05-04 Impact factor: 17.745

Review 2. Dengue and dengue vectors in the WHO European region: past, present, and scenarios for the future.

Authors: Francis Schaffner; Alexander Mathis
Journal: Lancet Infect Dis Date: 2014-08-26 Impact factor: 25.071

3. No shortcuts to SARS-CoV-2 antivirals.

Authors: Aled Edwards; Ingo V Hartung
Journal: Science Date: 2021-07-30 Impact factor: 47.728

Review 4. Broad-Spectrum Flavivirus Inhibitors: a Medicinal Chemistry Point of View.

Authors: Tommaso Felicetti; Giuseppe Manfroni; Violetta Cecchetti; Rolando Cannalire
Journal: ChemMedChem Date: 2020-10-22 Impact factor: 3.466

Review 5. Broad-spectrum agents for flaviviral infections: dengue, Zika and beyond.

Authors: Veaceslav Boldescu; Mira A M Behnam; Nikos Vasilakis; Christian D Klein
Journal: Nat Rev Drug Discov Date: 2017-05-05 Impact factor: 84.694

Review 6. Lipids and flaviviruses, present and future perspectives for the control of dengue, Zika, and West Nile viruses.

Authors: Miguel A Martín-Acebes; Ángela Vázquez-Calvo; Juan-Carlos Saiz
Journal: Prog Lipid Res Date: 2016-10-01 Impact factor: 16.195

7. Discovery, X-ray Crystallography and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease.

Authors: Yuan Yao; Tong Huo; Yi-Lun Lin; Shenyou Nie; Fangrui Wu; Yuanda Hua; Jingyu Wu; Alexander R Kneubehl; Megan B Vogt; Rebecca Rico-Hesse; Yongcheng Song
Journal: J Am Chem Soc Date: 2019-04-23 Impact factor: 15.419

Review 8. Targeting the protease of West Nile virus.

Authors: Saan Voss; Christoph Nitsche
Journal: RSC Med Chem Date: 2021-05-26

Review 9. Dengue drug discovery: Progress, challenges and outlook.

Authors: Siew Pheng Lim
Journal: Antiviral Res Date: 2018-12-29 Impact factor: 5.970

10. Association of Statins and 28-Day Mortality Rates in Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 Infection.

Authors: Zoe N Memel; Jenny J Lee; Andrea S Foulkes; Raymond T Chung; Tanayott Thaweethai; Patricia P Bloom
Journal: J Infect Dis Date: 2022-01-05 Impact factor: 5.226

3 in total