Photoinitiated Multicomponent Anti-Markovnikov Alkoxylation over Graphene Oxide.

The development of graphene oxide-based heterogeneous materials with an economical and environmentally-friendly manner has the potential to facilitate many important organic transformations but proves to have few relevant reported reactions. Herein, we explore the synergistic role of catalytic systems driven by graphene oxide and visible light that form nucleophilic alkoxyl radical intermediates, which enable an anti-Markovnikov addition exclusively to the terminal alkenes, and then the produced benzyl radicals are subsequently added with N-methylquinoxalones. This photoinduced cascade radical difunctionalization of olefins offers a concise and applicable protocol for constructing alkoxyl-substituted N-methylquinoxalones.

1. Introduction

The graphene oxide (GO), as one of the popular carbocatalysts with two-dimensional honeycomb structures, has giant π-conjugated systems, unpaired electrons and several oxygen-containing function groups, such as hydroxy, epoxide, carbonyl and carboxyl groups, which have the acidic, nucleophilic and oxidized capabilities [1,2,3,4,5,6,7,8,9,10]. These unique chemical structures of GOs play an important role in its acidic, nucleophilic and oxidized capabilities. The superior electrical conductivity, high specific surface area and excellent optical transmittance impart to GO crucial properties such as: a template for anchor active species to metal or photocatalysts, and synergistic interactions between them resulting in improved yield [11,12,13,14]. Given such a situation, GO-based photocatalysts offer prospective applications to associate with photoenergy conversion, and the exploration of different approaches in organic transformations have been also improved by GO-based photocatalytic redox processes.

The alkoxyl radicals are versatile reactive intermediates which have been widely exploited in various organic transformations [15,16,17,18,19,20,21]. Compared to aryloxy radicals, this electrophilic O-centered radicals lack the stabilization of mesomeric effects and spin density delocalization compared with aryloxy radicals. The cleavage of N-O bond from various N-alkoxypyridinium ions (NAPs) generates the corresponding alkoxyl radicals, affording attractive approaches to the construction of C-O bond under visible light-induced conditions [22,23,24,25]. A plethora of these O-radical intermediates is commonly considered as a powerful toolbox for synthetic and mechanistic studies, which participates in oxidation, hydrogen atom transfer (HAT) and radical addition reactions (Scheme 1a). For example, the photogeneration of alkoxy radicals via reductive cleavage of 4-cyano-substituted N-methoxypyridinium had oxidated alcohol to yield oxidation product [26]. Recently, the groups of Hong and Zhu independently described a generation of oxygen-centered radicals mediated by NAPs, and subsequent radical translocation easily activated the remote unactivated C(sp3)-H bonds by intramolecular 1,5-hydrogen atom transfer (1,5-HAT) [27,28,29]. For no hydrogen abstracted in intermolecular process, alkoxy radicals was efficiently trapped with styrenes by anti-Markovnikov regioselectivity [30,31]. However, the development of multicomponent reactions (MCR) of anti-Markovnikov alkoxylation is still great a challenge without traditional transition–metal catalysts. Thus, we intend to use NAPs that release alkoxyl radical through the synergistic effect of GO and visible-light excitation, and subsequent MCR the approach in anti-Markovnikov addition will have been smooth for constructing C3-substituted alkoxyquinoxalones (Scheme 1b).

Scheme 1

Diverse reactivities of alkoxyl radicals under photoredox catalysis.

2. Results

The GO material used in this investigation was prepared by Hummers oxidation of graphite and subsequent exfoliation, as reported [32]. The obtained GO material has been characterized by X-ray photoelectron spectroscopy (XPS), scanning electron microscope (SEM), and infrared spectrum (IR) (see the Supporting Information).

To validate the above design, we selected N-methyl quinoxalone (1a), styrene (2a) and 4-cyano-substituted N-methoxypyridinium salt (3a) as pilot substrates to test the difunctional reaction (Table 1). Based on extensive screening of conditions (see Supplementary Materials Table S1), we found that when using 80 wt% GO, 0.2 mmol 1a, 1.5 equivalents of 2a, and 3 equivalents of 3a in a mixed solvent of MeCN and H2O (70:1 v/v) at room temperature under the irradiation of 15 W blue LEDs, the expected three-component product 4a was obtained in 70% yield (Table 1, entry 1). When the other N-methoxypyridiniums without substitutes or bearing electron-donating and electron–withdrawing groups were used instead of N-methoxypyridinium salt (3a), the yields were substantially showed as disappointing results (entries 2–3). Next, the effect of photocatalysts, such as Ru(bpy)3Cl2 (entry 4) and fac-Ir(ppy)3, were evaluated, affording 39% and 37% conversion, respectively (entry 5). Notably, the low conversions were observed by using other solvents (entries 6–7). Moreover, adding small amount of water to CH3CN had a remarkable impact on the anti-Markovnikov alkoxylation yield (entry 8). The GO loadings were evaluated, the yield of alkoxyquinoxalone 4a decreased when the GO loadings were 50 wt% or 100 wt% (entries 9–10). Finally, no reaction was observed in the absence of GO as a photocatalyst or light (entry 11).

Table 1

Optimization of the reaction conditions

Entry	MeO• Source	Variation from the Conditions	Yield b (%)
1	3a	none	70
2	3b	none	30
3	3c– 3e	none	0
4	3a	5 mol% Ru(bpy)3Cl2 instead of GO	39
5	3a	5 mol% fac−Ir(ppy)3 instead of GO	37
6	3a	MeOH	30
7	3a	DMSO	40
8	3a	dry CH3CN or CH3CN:H2O (1:1 v/v)	0
9	3a	50 wt% GO instead of 80 wt% GO	38
10	3a	100 wt% GO instead of 80 wt% GO	69
11	3a	without light or GO	0

Reaction conditions: 1a (0.2 mmol, 1 equiv), 2a (0.3 mmol, 1.5 equiv), 3a (0.6 mmol, 3 equiv), GO (80 wt%), 15 w blue LEDs, Ar, rt, and 24 h. Isolated yield.

Encouraged by these promising results, we studied the general applicability of the developed reaction methods using various substituted quinoxalones 1, styrene 2a, and 4-cyano-substituted N-methoxypyridinium salts 3 to obtain methoxylquinoxalones 4, and the results are summarized in Scheme 2. At first, different N-methoxypyridinium salts (BF4−, OTf−, MeSO4−) as a methoxy source were tested under a nitrogen atmosphere and 15 W blue LEDs irradiation for 24 h (entries 1–3). However, the yields of the desired product were decreased in N-methoxypyridinium salts (X = OTf, MeSO4) (entries 2 and 3). Thus, N-methoxypyridinium salt 3a was selected as a methoxy source. Subsequently, the N-methylquinoxalones moiety bearing electron–rich (6,7-Me) and electron−deficient (6-Cl) were suitable for this transformation, affording the corresponding products 4b and 4c in 58% and 55% yield, respectively.

Scheme 2

Scope of the reaction with respect to various substituted quinoxalones ,. Reaction conditions: 1 (0.2 mmol, 1 equiv), 2a (0.3 mmol, 1.5 equiv), 3a (0.6 mmol, 3 equiv), GO (80 wt%), 15 w blue LEDs, Ar, rt, and 24 h. Isolated yield.

Further, substrates having various N-substituents, including benzyl, naphthalen-2-ylmethyl, hexyl, cyclohexylmethyl, allyl, propargyl, and 2-ethoxy-2-oxoethyl groups, reacted with equal ease with 2a and 3a to provide the corresponding methoxylquinoxalone derivatives (4d–4n) in moderate to good yields. Among them, the substituent effect on the benzyl ring was investigated. The results have shown that electron–donating substituents showed better results than electron-withdrawing substituents in this transformation. For example, 4-methylbenzyl derivative afforded the desired 4e in 60% yield. However, N-substituted benzyl derivatives with electron-withdrawing substituents (F, Cl, and CF3) provided the desired products 4f–4h in yields ranging from 33% to 45%. Quinoxalone bearing electron-neutral (N-H) was also found to furnish the desired product 4o in 58% yield. Furthermore, the structure of compound 4f was unambiguously confirmed by X-ray crystallographic analysis (see Supporting Information).

In order to expand the molecular library of methoxylquinoxalone frameworks, our work was extended to the usage of other substituted styrenes, and the results are summarized in Scheme 3. These results indicated that the electronic properties of the substituents on these styrenes showed little influence on the efficiency of this reaction. In general, the reactions of styrenes with electron-neutral (4-H), electron−deficient (4-CF3, 4-OCOMe), electron-rich (4-Me, 4-Bu-t), and halogenated (4-Cl, 3-Br) groups were all compatible to afford the corresponding products in moderate to good yields (43–70%; 4a, 4p−4u) under the optimal reaction conditions. It is noticed that 2-chlorostyrene was not good alkene substrate presumably due to the sterically hindered (2-Cl) substituent. Similarly, reaction of N-methylquinoxalone 1a and N-methoxypyridinium salt 3a with rigid 2-vinylnaphthalene gave desired product 4y in 26% yield. In addition, the feasibility of this protocol was further expanded by utilizing N-ethoxypyridinium salt 3b as an ethoxy source, which proceeded successfully under the optimized conditions to give the product 4z in 62% yield.

Scheme 3

Scope of the reaction with respect to various substituted quinoxalones ,. Reaction conditions: 1a (0.2 mmol, 1 equiv), 2 (0.3 mmol, 1.5 equiv), 3 (0.6 mmol, 3 equiv), GO (80 wt%), 15 w blue LEDs, Ar, rt, and 24 h. Isolated yield.

UV–vis absorption experiments were performed to examine the role of photocatalysts, and the results showed that GO exhibited evident absorption in the visible-light region (Figure 1a). Based on the absorption experiments, we anticipated no photoactive electron donor–acceptor (EDA) aggregation between GO, quinoxalone 1a, styrene 2a, and 4–cyano–substituted N–methoxypyridinium 3a. The fluorescence excitation spectrum were excited at 419 nm and 437 nm (excitation maximum of GO), respectively (Figure 1b). The two values were in the range of 380–500 nm, and so the blue light LED lamp was effective for this reaction. Fluorescence quenching techniques and the Stern-Volmer analysis on 1a, 2a and 3a showed effective quenching of the photoluminescence of GO, which revealed that the quenching of GO was directly proportional to the concentrations of substrates (Figure 1c,d). These investigations showed the single–electron transfer (SET) between GO and substrates under visible–light irradiation.

Figure 1

Ultraviolet–visible absorption and Stern–Volmer quenching experiments. (a) UV–visible spectra of GO and different substrates. (b) The fluorescence excitation spectrum of GO. (c) The fluorescence emission spectra of GO with different concentration of added quencher excited at 437 nm. (d) GO emission quenching by linear quenching on different concentrations of substrates.

Various control experiments were conducted to shine light on the plausible mechanism of this three-component cascade process. As showed in Scheme 4 (1), no reaction took place, or it was not effective for this anti-Markovnikov addition under an oxygen or air atmosphere. When dibutylhydroxytoluene (BHT) or (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO) was put into the standard reaction conditions, the reaction was completely suppressed, strongly suggesting the involvement of alkoxy radicals in product formation (Scheme 4 (2) and (3)). Moreover, the radical addition products I and II were detected by LC-MS, indicating the presence of methoxybenzyl radicals A after methoxy radical intermediates addition to the styrenes (Scheme 4 (3)). In addition, the radical clock reaction of diethyl 2,2-diallylmalonate 5 with 1a and 3a delivered the cyclopentane derivative III in favor of the cis-selectivity assigned on the Beckwith-Houk model (Scheme 4 (4)) [33,34,35]. These results indicated that free radical mechanism for this three-component cascade transformation was initiated by the alkoxy radical.

Scheme 4

Control experiments.

The catalyst reusability was examined. The GO was separated by filtration after the first reaction run and used for the second one under the same conditions. However, the yield of 3a is very low, indicating that the recovered-GO is ineffective.

X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared (FT-IR) analysis showed that a large of epoxide groups and carbonyl functional groups are lost when GO participates the reaction (Figures S1 and S3). The GO and recovered-GO (GO-R) were analyzed by XPS in order to study the surface chemical state and chemical composition of GO and GO-R. The full-scale XPS spectrum (Figure S3) proved that GO have C, O and S elements. For GO-R, the presence of C, O, S, F and B were confirmed by survey XPS spectra, indicating that the anion BF4− was successfully doped in carbon catalyst.

Based on the current results and previous reports [36,37], the following tentative SET mechanism for this metal–free domino process was depicted in Scheme 5. Initiation proceeds had driven by the synergistic effect of GO and visible light-mediated C-O bond cleavage of N-methoxypyridinium that generated the corresponding methoxy-radical. Then, methoxy radical added to the C=C bond of styrene 2a, delivering nucleophilic β-methoxylated radical A. Sequentially, the addition of chemo-selective intermediate A to the electrophilic C=N bond in substrate 1a afforded nitrogen radical intermediate B, which could be further oxidized by GO through SET and deprotonation process to give the desired product 4a.

Scheme 5

Proposed reaction mechanism.

3. Materials and Methods

3.1. General Information

Unless otherwise specified, commercial reagents and solvents were used without further purification. Commercially available chemicals were purchased from Leyan (Shanghai Haohong Scientific Co., Ltd. Shanghai, China) and used without any further purification. 1H and 13C NMR spectra were recorded on a Bruker spectrometers at 400 and 100 MHz, respectively. The chemical shifts were given in parts per million, relative to CDCl3 (7.26 ppm for 1H) and CDCl3 (77.0 ppm for 13C. Peak multiplicities were reported as follows: s, singlet; d, doublet; t, triplet; m, multiplet; br. s, broad singlet and J, coupling constant (Hz). Mass spectra were recorded with Bruker Dalton Esquire 3000 plus LC–MS apparatus. Elemental analyses were carried out on a Perkin-Elmer 240B instrument. HRFABMS spectra were recorded on a FTMS apparatus. Silica gel (300–400 mesh) was used for flash column chromatography, eluting (unless otherwise stated) with an ethyl acetate/petroleum ether (PE) (60–90 °C) mixture.

3.2. General Procedure of the Products 4

To a mixed solvent of MeCN and H2O (70:1 v/v) of quinoxalone 1 (0.2 mmol), N−methoxypyridinium salt 3a (0.6 mmol), and GO (80 wt%) was added styrene 2a (0.3 mmol) under an argon atmosphere irradiated by 15 w blue LEDs and the mixture was stirred at room temperature for 24 h. The reaction mixture was concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel (eluent: EtOAc/PE = 1:4) to yield the corresponding product 4.

3.3. Characterization Data of Products 4

3-(2-Methoxyl-1-phenylethyl)-methylquinoxalin-2(1H)-one 4a. Yellow solid (41 mg, 70%). Mp: 98−101 °C. 1H NMR (400 MHz, CDCl3): δ 7.96 (dd, J = 8.0, 1.2 Hz, 1H), 7.53 (dt, J = 1.2, 8.5 Hz, 1H), 7.50 (d, J = 8.5 Hz, 2H), 7.36 (t, J = 7.3 Hz, 1H), 7.31 (t, J = 7.3 Hz, 2H), 7.27 (d, J = 8.0 Hz, 1H), 7.23 (t, J = 7.3 Hz, 1H), 5.06 (dd, J = 9.0, 6.3 Hz, 1H), 4.41 (t, J = 9.0 Hz, 1H), 3.92 (dd, J = 9.0, 6.3 Hz, 1H), 3.64 (s, 3H), 3.41 (s, 3H). 13C NMR (100 MHz, CDCl3): δ 159.3, 154.6, 138.7, 133.1, 132.7, 130.3, 129.9, 128.7, 128.5, 127.1, 123.5, 113.5, 74.8, 59.0, 47.3, 29.1. HRESIMS calcd for [C18H18N2O2 + H]+ 295.1447, found 295.1454.

3-(2-Methoxy-1-phenylethyl)-1,6,7-trimethylquinoxalin-2(1H)-one 4b. Yellow solid (37 mg, 58%), Mp: 129–132 °C. 1H NMR (400 MHz, CDCl3): δ 7.71 (s, 1H), 7.49 (d, J = 7.4 Hz, 2H), 7.30 (t, J = 7.4 Hz, 2H), 7.21 (t, J = 7.4 Hz, 1H), 7.03 (s, 1H), 5.04 (t, J = 7.1 Hz, 1H), 4.37 (t, J = 8.9 Hz, 1H), 3.92 (t, J = 7.9 Hz, 1H), 3.61 (s, 3H), 3.40 (s, 3H), 2.42 (s, 3H), 2.38 (s, 3H). 13C NMR (100 MHz, CDCl3): δ 157.9, 154.6, 139.7, 139.0, 132.3, 131.1, 130.3, 128.7, 128.5, 128.4, 127.0, 114.1, 74.9, 59.0, 47.1, 29.1, 20.6, 19.2. HRESIMS calcd for [C20H22N2O2 + H]+ 323.1760, found 323.1769.

6-Chloro-3-(2-methoxyl-1-phenylethyl)-1-methylquinoxalin-2(1H)-one 4c. Yellow solid (36 mg, 55%). Mp: 127–130 °C. 1H NMR (400 MHz, CDCl3): δ 7.96 (s, 1H), 7.48 (d, J = 8.5 Hz, 2H), 7.47 (s, 1H), 7.31 (t, J = 7.0 Hz, 2H), 7.24 (d, J = 7.0 Hz, 1H), 7.19 (d, J = 8.5 Hz, 1H), 5.07 (t, J = 6.7 Hz, 1H), 4.38 (t, J = 9.1 Hz, 1H), 3.87 (dd, J = 6.7, 1.8 Hz, 1H), 3.61 (s, 3H), 3.40 (s, 3H). 13C NMR (100 MHz, CDCl3): δ 160.7, 154.2, 138.2, 133.2, 131.8, 129.9, 129.5, 128.8, 128.7, 128.6, 127.3, 114.7, 74.6, 59.0, 47.4, 29.3. HRESIMS calcd for [C18H17ClN2O2 + H]+ 329.1057, found 329.1067.

1-Benzyl-3-(2-methoxy-1-phenylethyl)quinoxalin-2(1H)-one 4d. Yellow solid (48 mg, 65%). Mp: 85–87 °C. 1H NMR (400 MHz, CDCl3): δ 7.99 (d, J = 7.8 Hz, 1H), 7.55 (d, J = 7.4 Hz, 2H), 7.41 (t, J = 7.7 Hz, 1H), 7.38–7.27 (m, 8H), 7.20 (d, J = 7.4 Hz, 2H), 5.54 (d, J = 15.6 Hz, 1H), 5.34 (d, J = 15.6 Hz, 1H), 5.17 (t, J = 7.0 Hz, 1H), 4.46 (t, J = 8.9 Hz, 1H), 3.98 (t, J = 8.3 Hz, 1H), 3.45 (s, 3H). 13C NMR (100 MHz, CDCl3): δ 159.4, 154.7, 138.7, 135.3, 133.0, 132.5, 130.4, 129.9, 128.9, 128.8, 128.6, 127.6, 127.2, 126.9, 123.6, 114.4. 74.9, 59.1, 47.4, 46.0. HRESIMS calcd for [C24H23N2O4 + H]+ 371.1754, found 371.1769.

3-(2-Methoxyl-1-phenylethyl)-1-(4-methylbenzyl)quinoxalin-2(1H)-one 4e. Yellow oil (46 mg, 60%). 1H NMR (400 MHz, CDCl3): δ 7.95 (d, J = 7.9 Hz, 1H), 7.52 (d, J = 7.5 Hz, 2H), 7.42 (t, J = 7.5 Hz, 1H), 7.33 (t, J = 7.1 Hz, 2H), 7.31 (t, J = 7.1 Hz, 1H), 7.25 (d, J = 7.9 Hz, 2H), 7.10 (s, 4H), 5.50 (d, J = 15.5 Hz, 1H), 5.29 (d, J = 15.5 Hz, 1H), 5.13 (t, J = 6.5 Hz, 1H), 4.43 (t, J = 9.1 Hz, 1H), 3.95 (dd, J = 9.1, 6.5 Hz, 1H), 3.43 (s, 3H), 2.31 (s, 3H). 13C NMR (100 MHz, CDCl3): δ 159.4, 154.6, 138.7, 137.3, 132.9, 132.5, 132.3, 130.4, 129.9, 129.5, 128.7, 128.5, 127.1, 126.9, 123.5, 114.4, 74.9, 59.0, 47.4, 45.8, 21.1. HRESIMS calcd for [C25H24N2O2 + H]+ 385.1916, found 385.1929.

1-(4-Fluorobenzyl)-3-(2-methoxy-1-phenylethyl)quinoxalin-2(1H)-one 4f. White solid (27 mg, 35%). Mp: 114–116 °C. 1H NMR (400 MHz, CDCl3): δ 7.94 (d, J = 7.4 Hz, 1H), 7.48 (d, J = 7.2 Hz, 2H), 7.40 (t, J = 7.2 Hz, 1H), 7.38–7.13 (m, 7H), 6.94 (d, J = 8.4 Hz, 2H), 5.44 (d, J = 15.3 Hz, 1H), 5.27 (d, J = 15.3 Hz, 1H), 5.09 (t, J = 7.3 Hz, 1H), 4.40 (d, J = 9.0 Hz, 1H), 3.91 (dd, J = 9.0, 7.3 Hz, 1H), 3.39 (s, 3H). 13C NMR (100 MHz, CDCl3): δ 162.0 (d, J = 246.4 Hz), 159.4, 154.5, 138.6, 132.9, 132.3, 131.0 (d, J = 3.1 Hz), 130.5, 129.9, 128.8, 128.7, 128.5, 127.1, 123.6, 115.8 (d, J = 21.7 Hz), 114.1, 74.8, 59.0, 47.4, 45.3. 19F NMR (376 MHz, CDCl3): δ −114.52; HRESIMS calcd for [C24H21FN2O2 + H]+ 389.1665, found 389.1651.

1-(2,6-Dichlorobenzyl)-3-(2-methoxy-1-phenylethyl)quinoxalin-2(1H)-one 4g. Yellow solid (29 mg, 33%). Mp: 85–86 °C. 1H NMR (400 MHz, CDCl3): δ 8.10 (d, J = 8.0 Hz, 1H), 7.87 (d, J = 8.0 Hz, 1H), 7.65 (t, J = 7.3 Hz, 1H), 7.59 (t, J = 7.3 Hz, 1H), 7.40 (d, J = 7.6 Hz, 2H), 7.30 (t, J = 7.6 Hz, 1H), 7.26 (d, J = 7.6 Hz, 2H), 7.18 (s, 3H), 5.79 (d, J = 11.4 Hz, 1H), 5.64 (d, J = 11.4 Hz, 1H), 4.80 (t, J = 7.0 Hz, 1H), 4.48 (t, J = 8.5 Hz, 1H), 4.02 (t, J = 7.9 Hz, 1H), 3.39 (s, 3H). 13C NMR (100 MHz, CDCl3): δ 155.2, 149.7, 139.7, 139.0, 138.8, 137.2, 132.1, 130.5, 129.3, 128.9, 128.7, 128.4, 128.3, 126.9, 126.8, 126.4, 74.6, 63.2, 59.1, 47.4. HRESIMS calcd for [C24H20Cl2N2O2 + H]+ 439.0980, found 439.0989.

3-(2-Methoxyl-1-phenylethyl)-1-(4-(trifluoromethyl)benzyl)quinoxalin-2(1H)-one 4h. Yellow oil (39 mg, 45%). 1H NMR (400 MHz, CDCl3): δ 8.00 (d, J = 7.9 Hz, 1H), 7.55 (d, J = 7.9 Hz, 2H), 7.52 (d, J = 7.9 Hz, 2H), 7.44 (t, J = 7.7 Hz, 1H), 7.36 (t, J = 7.7 Hz, 2H), 7.33 (t, J = 7.7 Hz, 1H), 7.31 (t, J = 7.5 Hz, 2H), 7.26 (t, J = 7.5 Hz, 1H), 7.14 (d, J = 7.9 Hz, 1H), 5.56 (d, J = 15.9 Hz, 1H), 5.40 (d, J = 15.9 Hz, 1H), 5.12 (t, J = 7.3 Hz, 1H), 4.45 (t, J = 9.1 Hz, 1H), 3.94 (dt, J = 9.1, 7.3 Hz, 1H), 3.44 (s, 3H). 13C NMR (100 MHz, CDCl3): δ 159.4, 154.5, 139.3, 138.5, 132.9, 132.2, 130.6, 130.1, 129.8, 128.7, 128.6, 127.2, 127.1, 125.9 (d, J = 7.7 Hz), 123.9 (q, J = 272.1 Hz), 123.8, 113.9, 74.8, 59.1, 47.5, 45.6. 19F NMR (376 MHz, CDCl3) δ −62.64; HRESIMS calcd for [C25H21F3N2O2 + H]+ 439.1633, found 439.1621.

3-(2-Methoxy-1-phenylethyl)-1-(naphthalen-2-ylmethyl)quinoxalin-2(1H)-one 4i. Yellow solid (29 mg, 35%). Mp: 56–58 °C. 1H NMR (400 MHz, CDCl3): δ 7.99 (d, J = 8.0 Hz, 1H), 7.80 (d, J = 4.9 Hz, 2H), 7.72 (t, J = 4.9 Hz, 1H), 7.59 (d, J = 7.9 Hz, 2H), 7.56 (s, 1H), 7.47 (t, J = 4.9 Hz, 2H), 7.40–7.30 (m, 7H), 5.72 (d, J = 15.8 Hz, 1H), 5.48 (d, J = 15.8 Hz, 1H), 5.19 (t, J = 7.3 Hz, 1H), 4.49 (t, J = 9.0 Hz, 1H), 3.99 (t, J = 7.8 Hz, 1H), 3.47 (s, 3H). 13C NMR (100 MHz, CDCl3): δ 159.4, 154.7, 138.7, 133.3, 133.0, 132.8, 132.7, 132.5, 130.4, 130.0, 128.9, 128.8, 128.6, 127.8, 127.7, 127.2, 126.4, 126.1, 125.6, 124.8, 123.6, 114.4, 74.9, 59.1, 47.5, 46.3. HRESIMS calcd for [C28H24N2O2 + H]+ 421.1916, found 421.1933.

1-Hexyl-3-(2-methoxy-1-phenylethyl)quinoxalin-2(1H)-one 4j. Yellow oli (35 mg, 48%). 1H NMR (400 MHz, CDCl3): δ 7.97 (d, J = 8.0 Hz, 1H), 7.52 (t, J = 7.0 Hz, 2H), 7.51 (s, 1H), 7.36–7.21 (m, 5H), 5.10 (t, J = 7.6 Hz, 1H), 4.42 (t, J = 9.0 Hz, 1H), 4.24 (dt, J = 7.8, 14.3 Hz, 1H), 4.11 (dt, J = 7.8, 14.3 Hz, 1H), 3.94 (t, J = 7.6 Hz, 1H), 3.42 (s, 3H), 1.71 (dt, J = 6.8, 15.5 Hz, 1H), 1.45–1.28 (m, 6H), 0.92 (t, J = 6.0 Hz, 1H). 13C NMR (100 MHz, CDCl3): δ 159.2, 154.2, 138.8, 133.0, 132.3, 130.5, 129.8, 128.7, 128.5, 127.1, 123.2, 113.5, 74.8, 59.0, 47.2, 42.5, 31.5, 27.2, 26.7, 22.6, 14.0. HRESIMS calcd for [C23H28N2O2 + H]+ 365.2229, found 365.2211.

1-(Cyclohexylmethyl)-3-(2-methoxy-1-phenylethyl)quinoxalin-2(1H)-one 4k. Colorless oil (48 mg, 64%). 1H NMR (400 MHz, CDCl3): δ 8.07 (d, J = 7.9 Hz, 1H), 7.78 (d, J = 7.9 Hz, 1H), 7.61 (t, J = 7.5 Hz, 1H), 7.55 (t, J = 7.1 Hz, 1H), 7.38 (d, J = 7.1 Hz, 2H), 7.28 (t, J = 6.8 Hz, 2H), 7.22 (d, J = 6.8 Hz, 1H), 4.85 (t, J = 6.4 Hz, 1H), 4.48 (t, J = 8.3 Hz, 1H), 4.22 (dd, J = 18.6, 5.6 Hz, 2H), 4.01 (t, J = 8.3 Hz, 1H), 3.41 (s, 3H), 1.82–1.68 (m, 7H), 1.30–1.23 (m, 2H), 1.08–1.00 (m, 2H). 13C NMR (100 MHz, CDCl3): δ 156.0, 149.8, 139.9, 139.4, 138.4, 129.1, 128.8, 128.7, 128.3, 126.9, 126.6, 126.0, 75.1, 71.6, 59.1, 47.5, 37.4, 29.8, 26.5, 25.8. HRESIMS calcd for [C24H28N2O2 + H]+ 377.2229, found 377.2254.

Ethyl 2-(3-(2-methoxy-1-phenylethyl)-2-oxoquinoxalin-1(2H)-yl)acetate 4l. White solid (40 mg, 60%). Mp: 86–89 °C. 1H NMR (400 MHz, CDCl3): δ 7.88 (dd, J = 8.0, 1.4 Hz, 1H), 7.41 (dt, J = 2.0, 8.0 Hz, 1H), 7.39 (dd, J = 3.6, 2.0 Hz, 1H), 7.37 (s, 1H), 7.28 (dt, J = 1.4, 8.0 Hz, 1H), 7.21 (t, J = 7.5 Hz, 2H), 7.13 (dt, J = 2.0, 7.5 Hz, 1H), 6.95 (d, J = 8.0 Hz, 1H), 4.95 (d, J = 17.3 Hz, 1H), 4.94 (dd, J = 8.3, 6.6 Hz, 1H), 4.78 (d, J = 17.3 Hz, 1H), 4.28 (dd, J = 9.3, 8.6 Hz, 1H), 4.11 (m, 2H), 3.83 (dd, J = 9.3, 6.6 Hz, 1H), 3.31 (s, 3H), 1.14 (t, J = 7.1 Hz, 3H). 13C NMR (100 MHz, CDCl3): δ 167.1, 159.0, 154.1, 138.5, 132.7, 132.2, 130.6, 130.1, 128.7, 128.6, 127.2, 123.8, 113.1, 74.7, 62.0, 59.0, 47.3, 43.7, 14.1. HRESIMS calcd for [C21H22N2O4 + H]+ 367.1658, found 367.1682.

1-Allyl-3-(2-methoxy-1-phenylethyl)quinoxalin-2(1H)-one 4m. White solid (38 mg, 60%). Mp: 76–78 °C. 1H NMR (400 MHz, CDCl3): δ 7.98 (d, J = 7.9 Hz, 1H), 7.53 (d, J = 7.5 Hz, 2H), 7.49 (t, J = 7.9 Hz, 1H), 7.35 (t, J = 7.9 Hz, 1H), 7.33 (t, J = 7.5 Hz, 2H), 7.26 (t, J = 8.3 Hz, 1H), 7.24 (t, J = 8.3 Hz, 1H), 5.95–5.83 (m, 1H), 5.24 (d, J = 10.3 Hz, 1H), 5.16 (d, J = 17.9 Hz, 1H), 5.11 (t, J = 7.1 Hz, 1H), 4.92 (dd, J = 15.9, 4.3 Hz, 1H), 4.77 (dd, J = 15.9, 4.3 Hz, 1H), 4.43 (t, J = 9.0 Hz, 1H), 3.94 (t, J = 7.7 Hz, 1H), 3.43 (s, 3H). 13C NMR (100 MHz, CDCl3): δ 159.3, 154.1, 138.7, 132.9, 132.4, 130.8, 130.4, 129.9, 128.7, 128.5, 127.1, 123.5, 118.2, 114.1, 74.9, 59.0, 47.3, 44.7. HRESIMS calcd for [C20H20N2O2 + H]+ 321.1603, found 321.1625.

3-(2-Methoxy-1-phenylethyl)-1-(prop-2-yn-1-yl)quinoxalin-2(1H)-one 4n. Yellow solid (38 mg, 60%). Mp: 87–90 °C. 1H NMR (400 MHz, CDCl3): δ 7.97 (d, J = 7.6 Hz, 1H), 7.57 (t, J = 7.6 Hz, 1H), 7.50 (d, J = 7.1 Hz, 2H), 7.44 (d, J = 8.3 Hz, 1H), 7.39 (t, J = 8.3 Hz, 1H), 7.31 (d, J = 7.1 Hz, 2H), 7.24 (t, J = 7.1 Hz, 1H), 5.08 (d, J = 17.4 Hz, 1H), 5.07 (t, J = 6.8 Hz, 1H), 4.90 (d, J = 17.4 Hz, 1H), 4.40 (t, J = 9.0 Hz, 1H), 3.90 (d, J = 7.9 Hz, 1H), 3.41 (s, 3H), 2.27 (s, 1H). 13C NMR (100 MHz, CDCl3): δ 159.1, 153.5, 138.4, 132.9, 131.6, 130.4, 130.0, 128.7, 128.5, 127.2, 123.8, 114.1, 76.8, 74.8, 73.2, 59.0, 47.3, 31.6. HRESIMS calcd for [C20H18N2O2 + H]+ 319.1447, found 319.1469.

3-(2-Methoxy-1-phenylethyl)quinoxalin-2(1H)-one 4o. Yellow solid (32 mg, 58%). Mp: 160–163 °C. 1H NMR (400 MHz, CDCl3): δ 12.24 (s, 1H), 7.92 (d, J = 8.0 Hz, 1H), 7.50 (d, J = 7.6 Hz, 1H), 7.49 (t, J = 8.5 Hz, 2H), 7.35 (t, J = 7.6 Hz, 1H), 7.30 (t, J = 8.5 Hz, 2H), 7.22 (t, J = 8.0 Hz, 2H), 5.07 (t, J = 7.0 Hz, 1H), 4.41 (t, J = 8.8 Hz, 1H), 3.95 (t, J = 7.6 Hz, 1H), 3.41 (s, 3H). 13C NMR (100 MHz, CDCl3): δ 159.7, 156.2, 138.6, 132.8, 130.9, 129.9, 129.2, 128.7, 128.5, 127.1, 124.0, 115.6, 74.8, 59.1, 46.8. HRESIMS calcd for [C17H16N2O2 + H]+ 281.1290, found 281.1296.

3-(2-Methoxyl-1-(p-tolyl)ethyl)-1-methylquinoxalin-2(1H)-one 4p. White solid (34 mg, 55%). Mp: 107–110 °C. 1H NMR (400 MHz, CDCl3): δ 7.95 (d, J = 7.5 Hz, 1H), 7.53 (t, J = 8.1 Hz, 1H), 7.40 (d, J = 7.7 Hz, 2H), 7.36 (t, J = 7.5 Hz, 1H), 7.26 (d, J = 8.1 Hz, 1H), 7.13 (d, J = 7.7 Hz, 2H), 5.04 (t, J = 6.7 Hz, 1H), 4.40 (t, J = 9.0 Hz, 1H), 3.92 (dd, J = 9.0, 6.7 Hz, 1H), 3.63 (s, 3H), 3.42 (s, 3H), 2.31 (s, 3H). 13C NMR (100 MHz, CDCl3): δ 159.4, 154.5, 136.7, 135.6, 133.1, 132.7, 130.2, 129.9, 129.3, 128.6, 123.4, 113.5, 74.8, 59.0, 46.9, 29.1, 21.1. HRESIMS calcd for [C19H20N2O2 + H]+ 309.1603, found 309.1021.

3-(1-(4-(tert-Butyl)phenyl)-2-methoxyl)-1-methylquinoxalin-2(1H)-one 4q. Yellow oil (32 mg, 55%). 1H NMR (400 MHz, CDCl3): δ 7.95 (dd, J = 8.3, 1.1 Hz, 1H), 7.52 (dt, J = 1.4, 8.6 Hz, 1H), 7.43 (dt, J = 1.4, 8.6 Hz, 2H), 7.36 (dt, J = 1.1, 8.3 Hz, 1H), 7.33 (dt, J = 1.4, 8.6 Hz, 2H), 7.26 (d, J = 8.3 Hz, 1H), 5.07 (dd, J = 9.2, 6.0 Hz, 1H), 4.42 (t, J = 9.2 Hz, 1H), 3.90 (dd, J = 9.2, 6.0 Hz, 1H), 3.64 (s, 3H), 3.41 (s, 3H), 1.29 (s, 9H). 13C NMR (100 MHz, CDCl3): δ 159.4, 154.6, 149.7, 135.4, 133.1, 132.7, 130.2, 129.8, 128.3, 125.5, 123.4, 113.5, 74.8, 59.0, 46.7, 34.4, 31.3, 29.1. HRESIMS calcd for [C22H26N2O2 + H]+ 351.2073, found 351.2075.

3-(1-(4-Chlorophenyl)-2-methoxyethyl)-1-methylquinoxalin-2(1H)-one 4r. Yellow solid (28 mg, 43%). Mp: 124–126 °C. 1H NMR (400 MHz, CDCl3): δ 7.94 (d, J = 8.0 Hz, 1H), 7.55 (d, J = 7.8 Hz, 1H), 7.44 (d, J = 8.0 Hz, 2H), 7.37 (t, J = 7.8 Hz, 1H), 7.28 (s, 1H), 7.27 (d, J = 8.0 Hz, 2H), 5.03 (t, J = 7.4 Hz, 1H), 4.32 (t, J = 8.8 Hz, 1H), 3.92 (t, J = 8.1 Hz, 1H), 3.64 (s, 3H), 3.40 (s, 3H). 13C NMR (100 MHz, CDCl3): δ 158.8, 154.4, 137.2, 133.1, 132.9, 132.6, 130.3, 130.2, 130.1, 128.6, 123.6, 113.6, 74.6, 59.0, 46.7, 29.2. HRESIMS calcd for [C18H17ClN2O2 + H]+ 329.1057, found 329.1077.

3-(2-Methoxyl-1-(4-(trifluoromethyl)phenyl)ethyl)-1-methylquinoxalin-2(1H)-one 4s. White solid (36 mg, 50%). Mp: 118–122 °C. 1H NMR (400 MHz, CDCl3): δ 7.95 (d, J = 8.0 Hz, 1H), 7.63 (d, J = 8.1 Hz, 2H), 7.57 (t, J = 8.0 Hz, 1H), 7.56 (d, J = 8.1 Hz, 2H), 7.39 (t, J = 7.6 Hz, 1H), 7.30 (d, J = 7.6 Hz, 1H), 5.11 (t, J = 7.3 Hz, 1H), 4.34 (t, J = 8.6 Hz, 1H), 3.98 (t, J = 8.6 Hz, 1H), 3.66 (s, 3H), 3.41 (s, 3H). 13C NMR (100 MHz, CDCl3): δ 158.4, 154.4, 142.9, 133.1, 132.6, 130.3, 129.4, 129.1, 128.8, 125.4 (d, J = 3.8 Hz), 124.2 (d, J = 272.0 Hz), 123.7, 113.6, 74.5, 59.1, 47.2, 29.2. 19F NMR (376 MHz, CDCl3) δ −62.49; HRESIMS calcd for [C19H17F3N2O2 + H]+ 363.1320, found 363.1334.

4-(2-Methoxy-1-(4-methyl-3-oxo-3,4-dihydroquinoxalin-2-yl)ethyl)phenyl acetate 4t. Yellow solid (37 mg, 52%). Mp: 128–130 °C. 1H NMR (400 MHz, CDCl3): δ 7.91 (dd, J = 8.0, 1.4 Hz, 1H), 7.52 (dt, J = 1.4, 8.5 Hz, 1H), 7.49 (dt, J = 2.6, 7.6 Hz, 2H), 7.34 (dt, J = 1.4, 7.6 Hz, 1H), 7.25 (d, J = 8.5 Hz, 1H), 6.99 (dt, J = 2.6, 8.6 Hz, 2H), 5.06 (dd, J = 8.6, 6.3 Hz, 1H), 4.36 (t, J = 9.0 Hz, 1H), 3.88 (dd, J = 9.0, 6.3 Hz, 1H), 3.63 (s, 3H), 3.38 (s, 3H), 2.26 (s, 3H). 13C NMR (100 MHz, CDCl3): δ 169.6, 158.9, 154.5, 149.7, 136.1, 133.1, 132.6, 130.2, 130.1, 129.8, 123.5, 121.5, 113.6, 74.6, 59.0, 46.6, 29.2, 21.2. HRESIMS calcd for [C20H20N2O4 + H]+ 353.1501, found 353.1487.

3-(1-(3-Bromophenyl)-2-methoxyethyl)-1-methylquinoxalin-2(1H)-one 4u. White solid (34 mg, 45%). Mp: 96–101 °C. 1H NMR (400 MHz, CDCl3): δ 7.94 (d, J = 8.2 Hz, 1H), 7.62 (d, J = 1.1 Hz, 1H), 7.53 (t, J = 7.8 Hz, 1H), 7.45 (d, J = 7.8 Hz, 1H), 7.36 (t, J = 7.1 Hz, 1H), 7.35 (d, J = 7.1 Hz, 1H), 7.26 (d, J = 8.2 Hz, 1H), 7.18 (t, J = 7.8 Hz, 1H), 5.02 (t, J = 7.7 Hz, 1H), 4.32 (t, J = 8.8 Hz, 1H), 3.92 (t, J = 8.8, 7.7 Hz, 1H), 3.63 (s, 3H), 3.40 (s, 3H). 13C NMR (100 MHz, CDCl3): δ 158.5, 154.4, 141.1, 133.1, 132.6, 131.5, 130.3, 130.2, 130.1, 130.0, 127.7, 123.6, 122.5, 113.6, 74.6, 59.1, 46.9, 29.2. HRESIMS calcd for [C18H17BrN2O2 + H]+ 373.0552, found 373.0558.

3-(2-Methoxyl-1-(o-tolyl)ethyl)-1-methylquinoxalin-2(1H)-one 4v. Yellow solid (32 mg, 52%). Mp:129–132 °C. 1H NMR (400 MHz, CDCl3): δ 8.00 (d, J = 7.8 Hz, 1H), 7.54 (t, J = 7.8 Hz, 1H), 7.38 (t, J = 7.6 Hz, 1H), 7.29–7.22 (m, 3H), 7.13 (t, J = 7.3 Hz, 1H), 7.08 (t, J = 7.3 Hz, 1H), 5.30 (dd, J = 8.6, 5.7 Hz, 1H), 4.42 (t, J = 9.2 Hz, 1H), 3.75 (dd, J = 9.2, 5.7 Hz, 1H), 3.63 (s, 3H), 3.42 (s, 3H), 2.72 (s, 3H). 13C NMR (100 MHz, CDCl3): δ 159.6, 154.6, 137.5, 136.9, 133.1, 132.7, 130.7, 130.3, 129.9, 127.1, 126.9, 125.8, 123.4, 113.5, 74.8, 59.1, 42.9, 29.1, 20.0. HRESIMS calcd for [C19H20N2O2 + H]+ 309.1603, found 309.1612.

3-(1-(2,5-Dimethylphenyl)-2-methoxyethyl)-1-methylquinoxalin-2(1H)-one 4w. Yellow solid (22 mg, 35%). Mp: 58–61 °C. 1H NMR (400 MHz, CDCl3): δ 8.02 (d, J = 8.0 Hz, 1H), 7.55 (t, J = 7.6 Hz, 1H), 7.40 (t, J = 7.6 Hz, 1H), 7.28 (d, J = 8.0 Hz, 1H), 7.13 (d, J = 7.6 Hz, 1H), 7.04 (s, 1H), 6.95 (d, J = 7.6 Hz, 1H), 5.26 (dd, J = 8.8, 5.5 Hz, 1H), 4.42 (t, J = 9.2 Hz, 1H), 3.75 (dd, J = 9.2, 5.5 Hz, 1H), 3.63 (s, 3H), 3.43 (s, 3H), 2.68 (s, 3H), 2.23 (s, 3H). 13C NMR (100 MHz, CDCl3): δ 159.7, 154.6, 136.6, 135.1, 134.3, 133.1, 132.7, 130.6, 130.3, 129.8, 127.8, 127.7, 123.4, 113.5, 74.7, 59.0, 43.0, 29.1, 21.1, 19.6. HRESIMS calcd for [C20H22N2O2 + H]+ 323.1760, found 323.1781.

3-(1-(2-Chlorophenyl)-2-methoxyethyl)-1-methylquinoxalin-2(1H)-one 4x. Yellow solid (16 mg, 25%). Mp: 94–96 °C. 1H NMR (400 MHz, CDCl3): δ 7.96 (d, J = 7.9 Hz, 1H), 7.57 (t, J = 7.9 Hz, 1H), 7.44 (d, J = 7.5 Hz, 1H), 7.38 (t, J = 7.5 Hz, 1H), 7.32 (t, J = 8.0 Hz, 1H), 7.31 (d, J = 8.0 Hz, 1H), 7.16 (dt, J = 4.9, 8.0 Hz, 2H), 5.61 (t, J = 7.0 Hz, 1H), 4.33 (t, J = 9.0 Hz, 1H), 3.82 (dd, J = 9.0, 5.7 Hz, 1H), 3.67 (s, 3H), 3.44 (s, 3H). 13C NMR (100 MHz, CDCl3): δ 158.7, 154.5, 136.4, 135.0, 133.2, 132.6, 130.4, 130.2, 129.9, 128.8, 128.2, 126.6, 123.5, 113.6, 73.7, 59.0, 43.4, 29.2. HRESIMS calcd for [C18H17ClN2O2 + H]+ 329.1057, found 329.1077.

3-(2-Methoxyl-1-(naphthalen-2-yl)ethyl)-1-methylquinoxalin-2(1H)-one 4y. Yellow solid (18 mg, 26%). Mp: 107–109 °C. 1H NMR (400 MHz, CDCl3): δ 8.00 (d, J = 8.0 Hz, 1H), 7.91 (s, 1H), 7.83–7.76 (m, 3H), 7.67 (d, J = 8.4 Hz, 1H), 7.54 (t, J = 8.0 Hz, 1H), 7.46–7.40 (s, 2H), 7.39 (d, J = 7.6 Hz, 1H), 7.27 (d, J = 8.4 Hz, 1H), 5.23 (t, J = 7.3 Hz, 1H), 4.49 (t, J = 9.0 Hz, 1H), 4.03 (t, J = 8.0 Hz, 1H), 3.63 (s, 3H), 3.43 (s, 3H). 13C NMR (100 MHz, CDCl3): δ 159.1, 154.5, 136.2, 133.5, 133.1, 132.7, 132.6, 130.3, 130.0, 128.2, 127.9, 127.6, 127.5, 126.9, 125.9, 125.6, 123.5, 113.6, 74.7, 59.1, 47.5, 29.2. HRESIMS calcd for [C22H20N2O2 + H]+ 345.1603, found 345.1615.

3-(2-ethoxy-1-phenylethyl)-1-methylquinoxalin-2(1H)-one 4z. Yellow solid (38 mg, 62%). Mp: 72–74 °C. 1H NMR (400 MHz, CDCl3): δ 7.93 (dd, J = 8.0, 1.3 Hz, 1H), 7.51 (dt, J = 1.3, 8.5 Hz, 1H), 7.46 (d, J = 7.3 Hz, 2H), 7.34 (t, J = 1.0, 8.0 Hz, 1H), 7.28 (t, J = 7.3 Hz, 1H), 7.26 (t, J = 8.5 Hz, 2H), 7.20 (dt, J = 1.0, 7.3 Hz, 1H), 5.03 (dd, J = 8.8, 6.0 Hz, 1H), 4.44 (t, J = 9.2 Hz, 1H), 3.90 (dd, J = 9.5, 6.0 Hz, 1H), 3.62 (s, 3H), 3.56 (q, J = 7.0 Hz, 2H), 1.13 (t, J = 7.0 Hz, 3H). 13C NMR (100 MHz, CDCl3): δ 159.3, 154.6, 138.8, 133.1, 132.7, 130.2, 129.9, 128.7, 128.5, 127.0, 123.4, 113.5, 72.5, 66.5, 47.5, 29.1, 15.1. HRESIMS calcd for [C19H20N2O2 + H]+ 309.1603, found 309.1620.

4. Conclusions

In summary, we have developed a novel GO/visible light dual catalytic system for the multicomponent anti-Markovnikov alkoxylation of styrenes with excellent regioselectivity under mild reaction conditions. This methodology exploits a commercially available GO as the inexpensive and green photoredox catalyst for the synthesis of methoxylquinoxalones. In this study, various synthetically relevant functional groups, such as halides, trifluoromethyl, esters, allyl, and propargyl, can be compatible. We believe this GO/visible light dual catalytic strategy will add prospective luminescence over expensive and toxic metal-catalyzed reactions in organic synthesis.