Sylvie Belleville1,2, Simon Cloutier1,2, Samira Mellah1, Sherry Willis3, Bruno Vellas4,5,6, Sandrine Andrieu5,6,7, Nicola Coley5,6,7, Tiia Ngandu8. 1. Research Center, Institut Universitaire de gériatrie de Montréal, Montreal, Quebec, Canada. 2. Psychology department, Faculty of Arts and Science, Université de Montréal, Montreal, Canada. 3. Department of Psychiatry, University of Washington, Seattle, Washington, USA. 4. Gérontopôle de Toulouse, CHU de Toulouse, Toulouse, France. 5. Center for Epidemiology and Research in Population health (CERPOP), University of Toulouse, Toulouse, France. 6. INSERM UMR1295, UPS, Toulouse, France. 7. Department of Clinical Epidemiology and Public Health, Toulouse University Hospital, Toulouse, France. 8. Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.
Abstract
BACKGROUND: Little is known regarding the dose-response function in multidomain interventions for dementia prevention. METHOD: The Multidomain Alzheimer Preventive Trial is a 3-year randomized controlled trial comprising cognitive training, physical activity, nutrition, and omega-3 polyunsaturated fatty acids for at-risk older adults. The dose delivered (number of sessions attended) was modeled against global cognition, memory, and fluency in 749 participants. Interaction effects were assessed for age, sex, education, dementia score (CAIDE), frailty score, and apolipoprotein E (APOE) ε4 status. RESULTS: The dose-response models were non-linear functions indicating benefits up to about 12 to 14 training hours or 15 to 20 multidomain sessions followed by a plateau. Participants who benefited from a higher dose included women, younger participants, frail individuals, and those with lower education or lower risk of dementia. DISCUSSION: The non-linear function indicates that a higher dose is not necessarily better in multidomain interventions. The optimal dose was about half of the potentially available sessions.
BACKGROUND: Little is known regarding the dose-response function in multidomain interventions for dementia prevention. METHOD: The Multidomain Alzheimer Preventive Trial is a 3-year randomized controlled trial comprising cognitive training, physical activity, nutrition, and omega-3 polyunsaturated fatty acids for at-risk older adults. The dose delivered (number of sessions attended) was modeled against global cognition, memory, and fluency in 749 participants. Interaction effects were assessed for age, sex, education, dementia score (CAIDE), frailty score, and apolipoprotein E (APOE) ε4 status. RESULTS: The dose-response models were non-linear functions indicating benefits up to about 12 to 14 training hours or 15 to 20 multidomain sessions followed by a plateau. Participants who benefited from a higher dose included women, younger participants, frail individuals, and those with lower education or lower risk of dementia. DISCUSSION: The non-linear function indicates that a higher dose is not necessarily better in multidomain interventions. The optimal dose was about half of the potentially available sessions.
Authors: Manuel Montero-Odasso; G Y Zou; Nellie Kamkar; Howard H Feldman; Sylvie Belleville; Howard Chertkow; Haakon B Nygaard; Surim Son; Mark Speechley Journal: Alzheimers Res Ther Date: 2022-07-11 Impact factor: 8.823
Authors: Rosie Essery; Sebastien Pollet; Katherine Bradbury; Max J Western; Elisabeth Grey; James Denison-Day; Kirsten A Smith; Victoria Hayter; Joanne Kelly; Jane Somerville; Beth Stuart; Taeko Becque; Jin Zhang; Joanna Slodkowska-Barabasz; Fiona Mowbray; Anne Ferrey; Guiqing Yao; Shihua Zhu; Tony Kendrick; Simon Griffin; Nanette Mutrie; Sian Robinson; Helen Brooker; Gareth Griffiths; Louise Robinson; Martin Rossor; Clive Ballard; John Gallacher; Shanaya Rathod; Bernard Gudgin; Rosemary Phillips; Tom Stokes; John Niven; Paul Little; Lucy Yardley Journal: Front Public Health Date: 2022-09-20