Letizia Squarcina1, Lana Kambeitz-Ilankovic2,3, Carolina Bonivento4, Cecilia Prunas5, Lucio Oldani5, Julian Wenzel3, Anne Ruef2, Dominic Dwyer2, Adele Ferro5, Stefan Borgwardt6,7, Joseph Kambeitz3, Theresa Katharina Lichtenstein3, Eva Meisenzahl8, Christos Pantelis9, Marlene Rosen2, Rachel Upthegrove10, Linda A Antonucci11, Alessandro Bertolino12, Rebekka Lencer7,13, Stephan Ruhrmann3, Raimo R K Salokangas14, Frauke Schultze-Lutter8,15, Katharine Chisholm10, Alexandra Stainton16, Stephen J Wood16,17,18, Nikolaos Koutsouleris2, Paolo Brambilla1,5. 1. Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy. 2. Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, Germany. 3. Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany. 4. IRCCS E. Medea, San Vito al Tagliamento, Italy. 5. Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. 6. Department of Psychiatry, (Psychiatric University Hospital, UPK), University of Basel, Basel, Switzerland. 7. Department of Psychiatry and Psychotherapy, University of Lubeck, Lubeck, Germany. 8. Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine University, Dusseldorf, Germany. 9. Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Melbourne, Australia. 10. Institute for Mental Health and Centre for Human Brain Health, University of Birmingham, Birmingham, UK. 11. Department of Education, Psychology and Communication, University of Bari "Aldo Moro" - Bari, Italy. 12. Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari "Aldo Moro", Bari, Italy. 13. Institute for Translational Psychiatry, Westfalische-Wilhelms-University Munster, Munster, Germany. 14. Department of Psychiatry, University of Turku, Turku, Finland. 15. Department of Psychology, Faculty of Psychology, Airlangga University, Surabaya, Indonesia. 16. Centre for Youth Mental Health, University of Melbourne, Parkville, Australia. 17. Orygen, Melbourne, Australia. 18. Institute for Mental Health, University of Birmingham, Birmingham, UK.
Abstract
OBJECTIVE: Psychotic disorders are frequently associated with decline in functioning and cognitive difficulties are observed in subjects at clinical high risk (CHR) for psychosis. In this work, we applied automatic approaches to neurocognitive and functioning measures, with the aim of investigating the link between global, social and occupational functioning, and cognition. METHODS: 102 CHR subjects and 110 patients with recent onset depression (ROD) were recruited. Global assessment of functioning (GAF) related to symptoms (GAF-S) and disability (GAF-D). and global functioning social (GF-S) and role (GF-R), at baseline and of the previous month and year, and a set of neurocognitive measures, were used for classification and regression. RESULTS: Neurocognitive measures related to GF-R at baseline (r = 0.20, p = 0.004), GF-S at present (r = 0.14, p = 0.042) and of the past year (r = 0.19, p = 0.005), for GAF-F of the past month (r = 0.24, p < 0.001) and GAF-D of the past year (r = 0.28, p = 0.002). Classification reached values of balanced accuracy of 61% for GF-R and GAF-D. CONCLUSION: We found that neurocognition was related to psychosocial functioning. More specifically, a deficit in executive functions was associated to poor social and occupational functioning.
OBJECTIVE: Psychotic disorders are frequently associated with decline in functioning and cognitive difficulties are observed in subjects at clinical high risk (CHR) for psychosis. In this work, we applied automatic approaches to neurocognitive and functioning measures, with the aim of investigating the link between global, social and occupational functioning, and cognition. METHODS: 102 CHR subjects and 110 patients with recent onset depression (ROD) were recruited. Global assessment of functioning (GAF) related to symptoms (GAF-S) and disability (GAF-D). and global functioning social (GF-S) and role (GF-R), at baseline and of the previous month and year, and a set of neurocognitive measures, were used for classification and regression. RESULTS: Neurocognitive measures related to GF-R at baseline (r = 0.20, p = 0.004), GF-S at present (r = 0.14, p = 0.042) and of the past year (r = 0.19, p = 0.005), for GAF-F of the past month (r = 0.24, p < 0.001) and GAF-D of the past year (r = 0.28, p = 0.002). Classification reached values of balanced accuracy of 61% for GF-R and GAF-D. CONCLUSION: We found that neurocognition was related to psychosocial functioning. More specifically, a deficit in executive functions was associated to poor social and occupational functioning.
Authors: Jonah F Byrne; Colm Healy; David Mongan; Subash Raj Susai; Stan Zammit; Melanie Fӧcking; Mary Cannon; David R Cotter Journal: Transl Psychiatry Date: 2022-09-09 Impact factor: 7.989