Literature DB >> 35044

Effects of maternal position on epidural anesthesia for cesarean section, acid-base status, and bupivacaine concentrations at delivery.

S Datta, M H Alper, G W Ostheimer, W U Brown, J B Weiss.   

Abstract

In 25 patients excellent clinical anesthesia for elective cesarean section was obtained with lumbar epidural block using an average dose of bupivacaine of 130 mg (18 ml of 0.75 per cent solution). Supplemental drugs were not needed. All infants had normal Apgar scores at delivery. Ten patients were kept in a 35--40 degree semi-sitting supine position during induction, while 15 patients were similarly semi-sitting but turned into the left lateral position. Maternal position did not affect the adequacy of the anesthesia or the clinical condition of the infants, but did alter acid-base state and bupivacaine concentrations in the infants. At delivery, the infants whose mothers had been supine had significantly lower pH values in umbilical cord blood than those whose mothers had been in the lateral position. Also, high concentrations of bupivacaine were found in the umbilical vein blood of infants whose mothers were supine.

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Year:  1979        PMID: 35044     DOI: 10.1097/00000542-197903000-00007

Source DB:  PubMed          Journal:  Anesthesiology        ISSN: 0003-3022            Impact factor:   7.892


  4 in total

1.  Prophylactic intramuscular ephedrine before epidural anaesthesia for caesarean section: efficacy and actions on the fetus and newborn.

Authors:  S H Rolbin; A F Cole; E M Hew; A Pollard; S Virgint
Journal:  Can Anaesth Soc J       Date:  1982-03

Review 2.  Drug kinetics in childbirth.

Authors:  R L Nation
Journal:  Clin Pharmacokinet       Date:  1980 Jul-Aug       Impact factor: 6.447

3.  Obstetrical anaesthesia practice in the University of Toronto affiliated hospitals and some randomly selected community hospitals.

Authors:  E M Hew; S H Rolbin; A F Cole; S Virgint
Journal:  Can Anaesth Soc J       Date:  1981-03

Review 4.  Drug Transporters Expressed in the Human Placenta and Models for Studying Maternal-Fetal Drug Transfer.

Authors:  André Dallmann; Xiaomei I Liu; Gilbert J Burckart; John van den Anker
Journal:  J Clin Pharmacol       Date:  2019-09       Impact factor: 3.126

  4 in total

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