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Literature DB >> 3504233

Preservation of the substantia nigra and locus coeruleus in a patient receiving levodopa (2 kg) plus decarboxylase inhibitor over a four-year period.

N Quinn¹, D Parkes, I Janota, C D Marsden.

Abstract

A 72-year-old hypertensive man developed parkinsonism and was treated with Sinemet for 4 years but then died of a bronchial carcinoma. Necropsy revealed cerebrovascular disease and amyloid angiopathy. The substantia nigra and locus coeruleus were normal on light microscopy.

Entities: Chemical Disease Species

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Year: 1986 PMID： 3504233 DOI： 10.1002/mds.870010109

Source DB: PubMed Journal: Mov Disord ISSN： 0885-3185 Impact factor: 10.338

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Cited

20 in total

Review 1. Pharmacological treatment of Parkinson's disease.

Authors: A Münchau; K P Bhatia
Journal: Postgrad Med J Date: 2000-10 Impact factor: 2.401

2. The L-dopa response in vascular parkinsonism.

Authors: J C M Zijlmans; R Katzenschlager; S E Daniel; A J L Lees
Journal: J Neurol Neurosurg Psychiatry Date: 2004-04 Impact factor: 10.154

3. Motor function, graft survival and gliosis in rats with 6-OHDA lesions and foetal ventral mesencephalic grafts chronically treated with L-dopa and carbidopa.

Authors: S B Blunt; P Jenner; C D Marsden
Journal: Exp Brain Res Date: 1992 Impact factor: 1.972

4. Glia protect fetal midbrain dopamine neurons in culture from L-DOPA toxicity through multiple mechanisms.

Authors: M A Mena; M J Casarejos; A Carazo; C L Paíno; J García de Yébenes
Journal: J Neural Transm (Vienna) Date: 1997 Impact factor: 3.575

5. Induction of apoptosis in catecholaminergic PC12 cells by L-DOPA. Implications for the treatment of Parkinson's disease.

Authors: G Walkinshaw; C M Waters
Journal: J Clin Invest Date: 1995-06 Impact factor: 14.808

Preservation of the substantia nigra and locus coeruleus in a patient receiving levodopa (2 kg) plus decarboxylase inhibitor over a four-year period.

Review 1. Pharmacological treatment of Parkinson's disease.

2. The L-dopa response in vascular parkinsonism.

3. Motor function, graft survival and gliosis in rats with 6-OHDA lesions and foetal ventral mesencephalic grafts chronically treated with L-dopa and carbidopa.

4. Glia protect fetal midbrain dopamine neurons in culture from L-DOPA toxicity through multiple mechanisms.

5. Induction of apoptosis in catecholaminergic PC12 cells by L-DOPA. Implications for the treatment of Parkinson's disease.

Review 6. Drug treatment of Parkinson's disease: is "polypharmacy" best?

Review 7. Levodopa in Parkinson's disease: neurotoxicity issue laid to rest?

Review 8. Does levodopa accelerate Parkinson's disease?

Review 9. The role of astroglia on the survival of dopamine neurons.

Review 10. Idiopathic Parkinson's disease: epidemiology, diagnosis and management.