Angela Sekely1,2, Konstantine K Zakzanis3,4, Donald Mabbott4,5, Derek S Tsang6,7, Paul Kongkham8, Gelareh Zadeh8, Kim Edelstein3,9,10. 1. Graduate Department of Psychological Clinical Science, University of Toronto, Toronto, ON, Canada. angie.sekely@mail.utoronto.ca. 2. Department of Supportive Care, Princess Margaret Cancer Centre, Toronto, ON, Canada. angie.sekely@mail.utoronto.ca. 3. Graduate Department of Psychological Clinical Science, University of Toronto, Toronto, ON, Canada. 4. Department of Psychology, University of Toronto, Toronto, ON, Canada. 5. Department of Psychology, Neurosciences, and Mental Health Program, The Hospital for Sick Children, Toronto, ON, Canada. 6. Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON, Canada. 7. Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada. 8. Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, Toronto, ON, Canada. 9. Department of Supportive Care, Princess Margaret Cancer Centre, Toronto, ON, Canada. 10. Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
Abstract
INTRODUCTION: This study aimed to investigate long-term neurocognitive, psychological, and return to work (RTW) outcomes in meningioma patients, and to explore whether neurocognitive and psychological factors influence RTW outcomes in this population. METHODS: In this retrospective study, 61 meningioma patients completed in-depth clinical neuropsychological assessments. Of these participants, 42 were of working-age and had RTW information available following neuropsychological assessment. Seventy-one percent and 80% of patients received radiation and surgery, respectively, with 49% receiving both radiation and surgery. Associations between demographic, medical, neurocognitive, psychological, and RTW data were analyzed using multivariable logistic regression analyses. RESULTS: In our sample, 68% of patients exhibited global neurocognitive impairment, with the largest effect sizes found on tests of visual memory (d = 0.73), executive function (d = 0.61), and attention (d = 0.54). Twenty-seven percent exhibited moderate to severe levels of depressive symptoms. In addition, 23% and 30% exhibited clinically significant state and trait anxiety, respectively. Forty-eight percent of patients were unable to RTW. Younger age, faster visuomotor processing speed, and, unexpectedly, higher trait anxiety scores were associated with an increased likelihood of returning to work. CONCLUSIONS: Meningioma patients are at risk of experiencing neurocognitive deficits, psychological symptoms, and difficulties returning to work. Our results suggest that neurocognitive and psychological factors contribute to RTW status in meningioma patients. Prospective research studies are necessary to increase our understanding of the complexity of functional disability in this growing population.
INTRODUCTION: This study aimed to investigate long-term neurocognitive, psychological, and return to work (RTW) outcomes in meningioma patients, and to explore whether neurocognitive and psychological factors influence RTW outcomes in this population. METHODS: In this retrospective study, 61 meningioma patients completed in-depth clinical neuropsychological assessments. Of these participants, 42 were of working-age and had RTW information available following neuropsychological assessment. Seventy-one percent and 80% of patients received radiation and surgery, respectively, with 49% receiving both radiation and surgery. Associations between demographic, medical, neurocognitive, psychological, and RTW data were analyzed using multivariable logistic regression analyses. RESULTS: In our sample, 68% of patients exhibited global neurocognitive impairment, with the largest effect sizes found on tests of visual memory (d = 0.73), executive function (d = 0.61), and attention (d = 0.54). Twenty-seven percent exhibited moderate to severe levels of depressive symptoms. In addition, 23% and 30% exhibited clinically significant state and trait anxiety, respectively. Forty-eight percent of patients were unable to RTW. Younger age, faster visuomotor processing speed, and, unexpectedly, higher trait anxiety scores were associated with an increased likelihood of returning to work. CONCLUSIONS: Meningioma patients are at risk of experiencing neurocognitive deficits, psychological symptoms, and difficulties returning to work. Our results suggest that neurocognitive and psychological factors contribute to RTW status in meningioma patients. Prospective research studies are necessary to increase our understanding of the complexity of functional disability in this growing population.
Authors: David N Louis; Arie Perry; Guido Reifenberger; Andreas von Deimling; Dominique Figarella-Branger; Webster K Cavenee; Hiroko Ohgaki; Otmar D Wiestler; Paul Kleihues; David W Ellison Journal: Acta Neuropathol Date: 2016-05-09 Impact factor: 17.088
Authors: M Dijkstra; D van Nieuwenhuizen; L J A Stalpers; M Wumkes; M Waagemans; W P Vandertop; J J Heimans; S Leenstra; C M Dirven; J C Reijneveld; M Klein Journal: J Neurol Neurosurg Psychiatry Date: 2008-07-24 Impact factor: 10.154