Literature DB >> 35040114

Histopathological evaluation of insulin-DMSO formula designed for direct nose-to-brain delivery.

Mustafa A Maher1, Wafaa A Kandeel2, Olfat A Hammam3, Yasmeen M Attia4, Soheir Mahmoud5, Mohamed Salah6.   

Abstract

The combination of insulin and DMSO is a patented (Publication No US8987199B2), noninvasive, pharmaceutically strategized preparation for direct nose-to-brain delivery (DN2BD) suggested for the treatment of Alzheimer's disease (AD). Although its main ingredients have been individually researched, no histopathological investigations have been conducted to address this combination effect on the CNS and nasal tissues in animals. The present work was, therefore, designed to investigate the potential histopathological changes induced by this new pharmaceutical combination using a newly developed refractory staining method. The findings presented herein showed no signs of treatment-related lesions or behavioral changes in Sprague Dawley rats following a three-month successive treatment with two strengths of the formula.

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Year:  2021        PMID： 35040114     DOI： 10.14670/HH-18-421

Source DB:  PubMed          Journal:  Histol Histopathol        ISSN： 0213-3911            Impact factor:   2.303


  24 in total

1.  Phenol stabilizes more helix in a new symmetrical zinc insulin hexamer.

Authors:  U Derewenda; Z Derewenda; E J Dodson; G G Dodson; C D Reynolds; G D Smith; C Sparks; D Swenson
Journal:  Nature       Date:  1989-04-13       Impact factor: 49.962

2.  Nanoformulation of synergistic TLR ligands to enhance vaccination against Entamoeba histolytica.

Authors:  Mayuresh M Abhyankar; Zannatun Noor; Mark A Tomai; James Elvecrog; Christopher B Fox; William A Petri
Journal:  Vaccine       Date:  2017-01-12       Impact factor: 3.641

Review 3.  Intranasal delivery to the central nervous system: mechanisms and experimental considerations.

Authors:  Shyeilla V Dhuria; Leah R Hanson; William H Frey
Journal:  J Pharm Sci       Date:  2010-04       Impact factor: 3.534

Review 4.  Histopathological image analysis: a review.

Authors:  Metin N Gurcan; Laura E Boucheron; Ali Can; Anant Madabhushi; Nasir M Rajpoot; B Yener
Journal:  IEEE Rev Biomed Eng       Date:  2009-10-30

Review 5.  Recent advances in carrier mediated nose-to-brain delivery of pharmaceutics.

Authors:  Vassilis Bourganis; Olga Kammona; Aleck Alexopoulos; Costas Kiparissides
Journal:  Eur J Pharm Biopharm       Date:  2018-05-04       Impact factor: 5.571

Review 6.  Intranasal insulin in Alzheimer's dementia or mild cognitive impairment: a systematic review.

Authors:  Konstantinos Ioannis Avgerinos; Grigorios Kalaitzidis; Antonia Malli; Dimitrios Kalaitzoglou; Pavlos Gr Myserlis; Vasileios-Arsenios Lioutas
Journal:  J Neurol       Date:  2018-02-01       Impact factor: 4.849

Review 7.  Diagnosis and treatment of dementia: 3. Mild cognitive impairment and cognitive impairment without dementia.

Authors:  Howard Chertkow; Fadi Massoud; Ziad Nasreddine; Sylvie Belleville; Yves Joanette; Christian Bocti; Valérie Drolet; John Kirk; Morris Freedman; Howard Bergman
Journal:  CMAJ       Date:  2008-05-06       Impact factor: 8.262

8.  Nose-to-brain drug delivery approach: A key to easily accessing the brain for the treatment of Alzheimer's disease.

Authors:  Amit Alexander; Shailendra Saraf
Journal:  Neural Regen Res       Date:  2018-12       Impact factor: 5.135

Review 9.  Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease.

Authors:  Leah R Hanson; William H Frey
Journal:  BMC Neurosci       Date:  2008-12-10       Impact factor: 3.288

Review 10.  Histological Stains: A Literature Review and Case Study.

Authors:  Hani A Alturkistani; Faris M Tashkandi; Zuhair M Mohammedsaleh
Journal:  Glob J Health Sci       Date:  2015-06-25
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