| Literature DB >> 35039640 |
Janie F Shelton1, Anjali J Shastri1, Kipper Fletez-Brant1, Stella Aslibekyan1, Adam Auton2.
Abstract
Using online surveys, we collected data regarding COVID-19-related loss of smell or taste from 69,841 individuals. We performed a multi-ancestry genome-wide association study and identified a genome-wide significant locus in the vicinity of the UGT2A1 and UGT2A2 genes. Both genes are expressed in the olfactory epithelium and play a role in metabolizing odorants. These findings provide a genetic link to the biological mechanisms underlying COVID-19-related loss of smell or taste.Entities:
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Year: 2022 PMID： 35039640 DOI： 10.1038/s41588-021-00986-w
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330