Literature DB >> 35038767

Nasal epithelial cells as a gold-standard predictive model for personalized medicine in cystic fibrosis.

Nicoletta Pedemonte1.   

Abstract

Entities:  

Keywords:  CFTR; modulators; mutation mechanism; organoids; theratype

Mesh：

Substances：

Year:  2022        PMID： 35038767     DOI： 10.1113/JP282586

Source DB:  PubMed          Journal:  J Physiol        ISSN： 0022-3751            Impact factor:   5.182


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  3 in total

Review 1.  Established and novel human translational models to advance cystic fibrosis research, drug discovery, and optimize CFTR-targeting therapeutics.

Authors:  Deborah M Cholon; Martina Gentzsch
Journal:  Curr Opin Pharmacol       Date:  2022-04-21       Impact factor: 4.768

2.  Theratyping of the Rare CFTR Variants E193K and R334W in Rectal Organoid-Derived Epithelial Monolayers.

Authors:  Fabiana Ciciriello; Marcel J C Bijvelds; Federico Alghisi; Kelly F Meijsen; Luca Cristiani; Claudio Sorio; Paola Melotti; Alessandro G Fiocchi; Vincenzina Lucidi; Hugo R De Jonge
Journal:  J Pers Med       Date:  2022-04-14

3.  The L467F-F508del Complex Allele Hampers Pharmacological Rescue of Mutant CFTR by Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis Patients: The Value of the Ex Vivo Nasal Epithelial Model to Address Non-Responders to CFTR-Modulating Drugs.

Authors:  Elvira Sondo; Federico Cresta; Cristina Pastorino; Valeria Tomati; Valeria Capurro; Emanuela Pesce; Mariateresa Lena; Michele Iacomino; Ave Maria Baffico; Domenico Coviello; Tiziano Bandiera; Federico Zara; Luis J V Galietta; Renata Bocciardi; Carlo Castellani; Nicoletta Pedemonte
Journal:  Int J Mol Sci       Date:  2022-03-15       Impact factor: 5.923
  3 in total

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