Sarah Beth Nossov1, Alejandro Quinonez2, Justin SanJuan2, John P Gaughan3, Josh Pahys2, Amer Samdani2, Jack Flynn4, Oscar H Mayer4, Sumeet Garg5, Michael Glotzbecker6, John Smith7, Patrick J Cahill4. 1. Shriners Hospitals for Children, 3551 N. Broad St., Philadelphia, PA, 19140, USA. snossov@gmail.com. 2. Shriners Hospitals for Children, 3551 N. Broad St., Philadelphia, PA, 19140, USA. 3. Cooper Medical School of Rowan University, Camden, NJ, USA. 4. Children's Hospital of Philadelphia, Philadelphia, PA, USA. 5. Children's Hospital Colorado, Aurora, CO, USA. 6. Rainbow Babies and Children's Hospital, Cleveland, OH, USA. 7. Primary Children's Medical Center, Salt Lake City, UT, USA.
Abstract
PURPOSE: Pulmonary function and quality of life (QOL) are important outcome measures for patients with early-onset scoliosis (EOS) undergoing rib-based growing system (RBGS) implantation. The Assisted Ventilation Rating (AVR) measures ventilator requirements in this population. A higher, more severe, score implies negative changes in QOL. The EOS Questionnaire (EOSQ) is a validated outcome measure. Paired measurements for both ratings were compared to clarify correlation between ventilator status and QOL. Secondary analysis aimed at defining QOL between more broad subgroups defined by ventilator use. METHODS: AVR and EOSQ scores were extracted from the Pediatric Spine Study Group database for patients 10 years of age and under. Instances were excluded if the time between AVR and EOSQ assessment was greater than 6 months. Scores were compared using Spearman correlation coefficient. Subgroup analysis included control for age, gender, and etiology. Secondary analysis was performed for broad functional grouping using ranked analysis of variance for repeated measures using median scores. RESULTS: Two thousand five hundred and forty-two instances of paired EOSQ and AVR in 329 patients were analyzed. A statistically significant weak correlation between AVR and EOSQ was identified in Child's Health Related QOL and Family Impact sections, in nine subsets. Subgroup analysis showed little variation, except increased correlation in female patients to near moderate level. Analysis of variance for demonstrated decreased medians for all subdomains when comparing those mechanically ventilated to patients who did not require ventilation. CONCLUSION: Ventilator status tracks with QOL were measured by EOSQ. A more severe AVR is negatively correlated with most domains of the EOSQ for patients with EOS who have undergone RBGS implantation. The strength of this correlation is weak, and so AVR alone may be insufficient to precisely determine QOL in this population. LEVEL OF EVIDENCE: Level-III, Retrospective.
PURPOSE: Pulmonary function and quality of life (QOL) are important outcome measures for patients with early-onset scoliosis (EOS) undergoing rib-based growing system (RBGS) implantation. The Assisted Ventilation Rating (AVR) measures ventilator requirements in this population. A higher, more severe, score implies negative changes in QOL. The EOS Questionnaire (EOSQ) is a validated outcome measure. Paired measurements for both ratings were compared to clarify correlation between ventilator status and QOL. Secondary analysis aimed at defining QOL between more broad subgroups defined by ventilator use. METHODS: AVR and EOSQ scores were extracted from the Pediatric Spine Study Group database for patients 10 years of age and under. Instances were excluded if the time between AVR and EOSQ assessment was greater than 6 months. Scores were compared using Spearman correlation coefficient. Subgroup analysis included control for age, gender, and etiology. Secondary analysis was performed for broad functional grouping using ranked analysis of variance for repeated measures using median scores. RESULTS: Two thousand five hundred and forty-two instances of paired EOSQ and AVR in 329 patients were analyzed. A statistically significant weak correlation between AVR and EOSQ was identified in Child's Health Related QOL and Family Impact sections, in nine subsets. Subgroup analysis showed little variation, except increased correlation in female patients to near moderate level. Analysis of variance for demonstrated decreased medians for all subdomains when comparing those mechanically ventilated to patients who did not require ventilation. CONCLUSION: Ventilator status tracks with QOL were measured by EOSQ. A more severe AVR is negatively correlated with most domains of the EOSQ for patients with EOS who have undergone RBGS implantation. The strength of this correlation is weak, and so AVR alone may be insufficient to precisely determine QOL in this population. LEVEL OF EVIDENCE: Level-III, Retrospective.
Authors: Sarah B Nossov; Evan Curatolo; Robert M Campbell; Oscar H Mayer; Sumeet Garg; And Patrick J Cahill Journal: J Pediatr Orthop Date: 2019-01 Impact factor: 2.324
Authors: Hiroko Matsumoto; Brendan Williams; Howard Y Park; Julie Y Yoshimachi; Benjamin D Roye; David P Roye; Behrooz A Akbarnia; John Emans; David Skaggs; John T Smith; Michael G Vitale Journal: J Pediatr Orthop Date: 2018-03 Impact factor: 2.324
Authors: Anna K Hell; Lena Braunschweig; Jennifer Behrend; Heiko M Lorenz; Konstantinos Tsaknakis; Urs von Deimling; Kiril Mladenov Journal: BMC Musculoskelet Disord Date: 2019-12-07 Impact factor: 2.362