| Literature DB >> 3503710 |
N Fraser1, A Ballabio, M Zollo, G Persico, I Craig.
Abstract
A cDNA clone (p422) containing about 200bp of coding sequences for steroid sulphatase (STS) has been isolated from a lambda gt11 expression library by antibody screening and has been assigned by mapping with a somatic cell hybrid panel and by in situ hybridization to Xp22.3; a localization coincident with the previously identified locus for STS expression. Although no significant hybridization of this clone to the Y chromosome was observed, p422 has been used to isolate a longer cDNA clone and genomic sequences which do recognize Y-specific restriction fragments. An abbreviated STS gene has been localized to Yq11.2. The coding sequences for the human enzyme shows little homology to sequences in mice.Entities:
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Year: 1987 PMID: 3503710 DOI: 10.1242/dev.101.Supplement.127
Source DB: PubMed Journal: Development ISSN: 0950-1991 Impact factor: 6.868