Sijing Duan1, Yong Jiang2, Kai Mou3, Yi Wang1, Shanshan Zhou4, Bingxin Sun5. 1. Department of Obstetrics, Zibo First Hospital Zibo, Shandong Province, China. 2. Department of Obstetrics, Zibo Maternal and Child Health Hospital Zibo, Shandong Province, China. 3. Department of Genetic Laboratory, Zibo Maternal and Child Health Hospital Zibo, Shandong Province, China. 4. Department of Pre-school Education, Zibo Normal College Zibo, Shandong Province, China. 5. Hospital Office, The Sixth People's Hospital of Zibo Zibo, Shandong Province, China.
Abstract
OBJECTIVE: To investigate the correlation of serum vitamin A and vitamin E levels with the occurrence and severity of preeclampsia. METHODS: The clinical data of 5,000 pregnant women in our hospital were retrospectively studied. Five hundred and sixty-five pregnant women with preeclampsia were divided into a mild group (259 cases) and a severe group (306 cases). The rest 4435 healthy pregnant women were classified as the healthy group. The concentrations of serum vitamin A and vitamin E in each group were compared to analyze the risk factors for preeclampsia. RESULTS: The levels of vitamin A and vitamin E were negatively correlated with the severity of preeclampsia (P<0.001). The logistic regression analysis showed that older age (OR=1.674), vitamin A deficiency (OR=2.463) and vitamin E deficiency (OR=2.206) were independent risk factors for preeclampsia (all P<0.05). CONCLUSION: Older age, vitamin A deficiency and vitamin E deficiency are the risk factors for preeclampsia. The concentrations of vitamin A and vitamin E are negatively correlated with the severity of preeclampsia. Vitamin A and vitamin E deficiencies in preeclampsia can increase the risk of adverse pregnancy outcomes, which needs timely intervention. AJTR
OBJECTIVE: To investigate the correlation of serum vitamin A and vitamin E levels with the occurrence and severity of preeclampsia. METHODS: The clinical data of 5,000 pregnant women in our hospital were retrospectively studied. Five hundred and sixty-five pregnant women with preeclampsia were divided into a mild group (259 cases) and a severe group (306 cases). The rest 4435 healthy pregnant women were classified as the healthy group. The concentrations of serum vitamin A and vitamin E in each group were compared to analyze the risk factors for preeclampsia. RESULTS: The levels of vitamin A and vitamin E were negatively correlated with the severity of preeclampsia (P<0.001). The logistic regression analysis showed that older age (OR=1.674), vitamin A deficiency (OR=2.463) and vitamin E deficiency (OR=2.206) were independent risk factors for preeclampsia (all P<0.05). CONCLUSION: Older age, vitamin A deficiency and vitamin E deficiency are the risk factors for preeclampsia. The concentrations of vitamin A and vitamin E are negatively correlated with the severity of preeclampsia. Vitamin A and vitamin E deficiencies in preeclampsia can increase the risk of adverse pregnancy outcomes, which needs timely intervention. AJTR
Authors: John Henry Dasinger; Justine M Abais-Battad; David L Mattson Journal: Am J Physiol Regul Integr Comp Physiol Date: 2020-05-20 Impact factor: 3.619
Authors: Piya Chaemsaithong; Diana Cuenca-Gomez; María N Plana; María M Gil; Liona C Poon Journal: Am J Obstet Gynecol Date: 2019-09-05 Impact factor: 8.661