Qi Cao1, Wei Zeng2, Jingmin Nie1, Yongjun Ye3, Yanchao Chen4. 1. First Department of Infectious Diseases, Chongqing Public Health Medical Center Chongqing 400033, China. 2. Department of Emergency, Chongqing Public Health Medical Center Chongqing 400033, China. 3. Department of General Surgery, Chongqing Public Health Medical Center Chongqing 400033, China. 4. Department of General Internal Medicine, Chongqing Public Health Medical Center Chongqing 400033, China.
Abstract
OBJECTIVE: To analyze the factors influencing the clinical effect of using respiratory humidifier in patients with AIDS complicated with severe Pneumocystis jiroveci pneumonia (PCP). METHODS: According to the treatment results, AIDS patients with severe PCP were divided into two groups, successful group (n=68) and failure group (n=94), to compare the early ventilation changes between the two groups. RESULTS: The ICU ratio of the successful group was lower than that of the failure group (P<0.05). The respiratory frequency, heart rate, PaO2, C-reactive protein and SOFA score of the successful group were lower than those in the failure group (P<0.05), while SpO2, FiO2, PaO2/FiO2, SpO2/FiO2, Rox index and IL-10 levels were increased in the successful group (P<0.05). The successful group had higher IL-6 and IL-1β level than that of the failure group. The levels of IL-8 were decreased (P<0.05). The success of respiratory humidifier was negatively correlated with the score of SOFA (P<0.05). CONCLUSION: The clinical effect of respiratory humidifier in the treatment of AIDS patients with severe PCP was related to PaO2/FiO2, PaO2, ROX index, SOFA score, and IL-6 and IL-8 levels. AJTR
OBJECTIVE: To analyze the factors influencing the clinical effect of using respiratory humidifier in patients with AIDS complicated with severe Pneumocystis jiroveci pneumonia (PCP). METHODS: According to the treatment results, AIDS patients with severe PCP were divided into two groups, successful group (n=68) and failure group (n=94), to compare the early ventilation changes between the two groups. RESULTS: The ICU ratio of the successful group was lower than that of the failure group (P<0.05). The respiratory frequency, heart rate, PaO2, C-reactive protein and SOFA score of the successful group were lower than those in the failure group (P<0.05), while SpO2, FiO2, PaO2/FiO2, SpO2/FiO2, Rox index and IL-10 levels were increased in the successful group (P<0.05). The successful group had higher IL-6 and IL-1β level than that of the failure group. The levels of IL-8 were decreased (P<0.05). The success of respiratory humidifier was negatively correlated with the score of SOFA (P<0.05). CONCLUSION: The clinical effect of respiratory humidifier in the treatment of AIDS patients with severe PCP was related to PaO2/FiO2, PaO2, ROX index, SOFA score, and IL-6 and IL-8 levels. AJTR
Authors: Oriol Roca; Berta Caralt; Jonathan Messika; Manuel Samper; Benjamin Sztrymf; Gonzalo Hernández; Marina García-de-Acilu; Jean-Pierre Frat; Joan R Masclans; Jean-Damien Ricard Journal: Am J Respir Crit Care Med Date: 2019-06-01 Impact factor: 21.405
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