Rita Nisticò1, Andrea Quattrone2,3, Marianna Crasà4, Marida De Maria4, Basilio Vescio5, Aldo Quattrone6,7. 1. Institute of Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR), Catanzaro, Italy. 2. Institute of Neurology, University "Magna Graecia", Catanzaro, Italy. 3. Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK. 4. Neuroscience Research Center, University "Magna Graecia", Viale Europa, 88100, Catanzaro, Italy. 5. Biotecnomed S.C.aR.L., Catanzaro, Italy. 6. Institute of Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR), Catanzaro, Italy. quattrone@unicz.it. 7. Neuroscience Research Center, University "Magna Graecia", Viale Europa, 88100, Catanzaro, Italy. quattrone@unicz.it.
Abstract
BACKGROUND: Rest tremor (RT) can be observed in several positions (seated, standing, lying down) but it is unknown whether the tremor features may vary across them. This study aimed to compare the RT electrophysiological features across different positions in tremor-dominant Parkinson's disease (PD) and essential tremor plus (ET with RT, rET). METHODS: We consecutively enrolled 90 tremor-dominant PD and 24 rET patients. The RT presence was evaluated in three positions: with the patient seated, the arm flexed at 90°, the forearm supported against gravity, and the hand hanging down from the chair armrest (hand-hanging position), in lying down supine and in standing position. RT electrophysiological features (amplitude, frequency, burst duration, pattern) were compared between the two patient groups and across the different positions. RESULTS: All PD and rET patients showed RT in hand-hanging position. Supine and standing RT were significantly more common in PD (67.8% and 75.6%, respectively) than in rET patients (37.5% and 45.8%, respectively). RT amplitude, frequency and pattern were significantly different between groups in hand-hanging position whereas only pattern was significantly different between PD and rET in both standing and supine positions. In each patient group, all RT electrophysiological features did not significantly vary across different recording positions (p > 0.05). DISCUSSION: In our study, PD and rET showed RT in hand-hanging, supine, and standing positions. RT pattern was the only electrophysiological feature significantly different between PD and rET patients in all these positions, enabling clinicians to perform the RT analysis for diagnostic purposes in different tremor positions.
BACKGROUND: Rest tremor (RT) can be observed in several positions (seated, standing, lying down) but it is unknown whether the tremor features may vary across them. This study aimed to compare the RT electrophysiological features across different positions in tremor-dominant Parkinson's disease (PD) and essential tremor plus (ET with RT, rET). METHODS: We consecutively enrolled 90 tremor-dominant PD and 24 rET patients. The RT presence was evaluated in three positions: with the patient seated, the arm flexed at 90°, the forearm supported against gravity, and the hand hanging down from the chair armrest (hand-hanging position), in lying down supine and in standing position. RT electrophysiological features (amplitude, frequency, burst duration, pattern) were compared between the two patient groups and across the different positions. RESULTS: All PD and rET patients showed RT in hand-hanging position. Supine and standing RT were significantly more common in PD (67.8% and 75.6%, respectively) than in rET patients (37.5% and 45.8%, respectively). RT amplitude, frequency and pattern were significantly different between groups in hand-hanging position whereas only pattern was significantly different between PD and rET in both standing and supine positions. In each patient group, all RT electrophysiological features did not significantly vary across different recording positions (p > 0.05). DISCUSSION: In our study, PD and rET showed RT in hand-hanging, supine, and standing positions. RT pattern was the only electrophysiological feature significantly different between PD and rET patients in all these positions, enabling clinicians to perform the RT analysis for diagnostic purposes in different tremor positions.
Authors: R Nisticò; D Pirritano; M Salsone; F Novellino; F Del Giudice; M Morelli; M Trotta; G Bilotti; F Condino; A Cherubini; P Valentino; A Quattrone Journal: Parkinsonism Relat Disord Date: 2010-11-10 Impact factor: 4.891
Authors: R Nisticò; A Fratto; B Vescio; G Arabia; G Sciacca; M Morelli; A Labate; M Salsone; F Novellino; A Nicoletti; A Petralia; A Gambardella; M Zappia; A Quattrone Journal: Parkinsonism Relat Disord Date: 2016-02-03 Impact factor: 4.891
Authors: Kailash P Bhatia; Peter Bain; Nin Bajaj; Rodger J Elble; Mark Hallett; Elan D Louis; Jan Raethjen; Maria Stamelou; Claudia M Testa; Guenther Deuschl Journal: Mov Disord Date: 2017-11-30 Impact factor: 10.338
Authors: Jaron van de Wardt; A M Madelein van der Stouwe; Michiel Dirkx; Jan Willem J Elting; Bart Post; Marina Aj Tijssen; Rick C Helmich Journal: J Neurol Neurosurg Psychiatry Date: 2020-05-26 Impact factor: 10.154