R Patel1, J Shen2, J F Nichols2, J T Schousboe3, G N Woods4, W B Katzman5, D M Kado6. 1. Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA. 2. Herbert Wertheim School of Public Health and Human Longevity Sciences, University of California San Diego, La Jolla, CA, USA. 3. Park Nicollet Clinic and Health Partners Institute and University of Minnesota, Minneapolis, MN, USA. 4. Department of Medicine, University of California San Diego and VA San Diego Health Care System, La Jolla, CA, USA. 5. University of California, San Francisco, San Francisco, CA, USA. 6. Department of Medicine, Stanford University, Stanford, California and VA Palo Alto, Palo Alto, CA, USA. dkado@stanford.edu.
Abstract
Hyperkyphosis (HK), or accentuated forward spinal curvature, commonly affects older people, although its causes are not completely understood. We tested whether a measure of bone quality, trabecular bone score (TBS), is associated with HK in 1997 older men, and determined that men with degraded TBS were more likely to have HK. INTRODUCTION: While vertebral fractures and low bone mineral density (BMD) contribute to kyphosis progression, it is unknown whether the trabecular bone score (TBS) may provide additional information on bone quality that could influence the degree of kyphosis. We hypothesized that degraded TBS would be associated with hyperkyphosis (HK) defined as a Cobb angle > 50°. METHODS: Using data from 1997 participants of the Osteoporotic Fractures in Men (MrOS) Study who had baseline TBS and Cobb angle kyphosis measured, we investigated whether men with degraded TBS were more likely to be hyperkyphotic, even after adjustment for BMD and prevalent vertebral fractures. RESULTS: Men were an average age of 74 ± 6 (mean ± SD) years with a mean kyphosis angle of 38.6 ± 11.5°, 295 (15%) were classified as hyperkyphotic, and 416 (21%) had degraded TBS. Compared with men with TBS > 1.2, men with degraded TBS were more likely to have HK (OR: 1.47, 95% CI: 1.06-2.06, p = 0.02) after adjusting for age, clinic, race, BMI, hip BMD, and prevalent vertebral fracture. If spine instead of hip BMD was included in the model, the odds ratio decreased to 1.35 (95% CI: 0.97-1.89, p = 0.08). CONCLUSIONS: Older men with degraded TBS are more likely to have HK not explained by underlying vertebral fractures.
Hyperkyphosis (HK), or accentuated forward spinal curvature, commonly affects older people, although its causes are not completely understood. We tested whether a measure of bone quality, trabecular bone score (TBS), is associated with HK in 1997 older men, and determined that men with degraded TBS were more likely to have HK. INTRODUCTION: While vertebral fractures and low bone mineral density (BMD) contribute to kyphosis progression, it is unknown whether the trabecular bone score (TBS) may provide additional information on bone quality that could influence the degree of kyphosis. We hypothesized that degraded TBS would be associated with hyperkyphosis (HK) defined as a Cobb angle > 50°. METHODS: Using data from 1997 participants of the Osteoporotic Fractures in Men (MrOS) Study who had baseline TBS and Cobb angle kyphosis measured, we investigated whether men with degraded TBS were more likely to be hyperkyphotic, even after adjustment for BMD and prevalent vertebral fractures. RESULTS: Men were an average age of 74 ± 6 (mean ± SD) years with a mean kyphosis angle of 38.6 ± 11.5°, 295 (15%) were classified as hyperkyphotic, and 416 (21%) had degraded TBS. Compared with men with TBS > 1.2, men with degraded TBS were more likely to have HK (OR: 1.47, 95% CI: 1.06-2.06, p = 0.02) after adjusting for age, clinic, race, BMI, hip BMD, and prevalent vertebral fracture. If spine instead of hip BMD was included in the model, the odds ratio decreased to 1.35 (95% CI: 0.97-1.89, p = 0.08). CONCLUSIONS: Older men with degraded TBS are more likely to have HK not explained by underlying vertebral fractures.
Authors: Deborah M Kado; Mei-Hua Huang; Arun S Karlamangla; Peggy Cawthon; Wendy Katzman; Teresa A Hillier; Kristine Ensrud; Steven R Cummings Journal: J Bone Miner Res Date: 2013-01 Impact factor: 6.741
Authors: C McDaniels-Davidson; A Davis; D Wing; C Macera; S P Lindsay; J T Schousboe; J F Nichols; D M Kado Journal: Osteoporos Int Date: 2017-10-10 Impact factor: 4.507
Authors: Karine Briot; Simon Paternotte; Sami Kolta; Richard Eastell; David M Reid; Dieter Felsenberg; Claus C Glüer; Christian Roux Journal: Bone Date: 2013-08-12 Impact factor: 4.398
Authors: Gina N Woods; Mei-Hua Huang; Joo-Hyun Lee; Peggy M Cawthon; Howard A Fink; John T Schousboe; Deborah M Kado Journal: J Bone Miner Res Date: 2020-08-12 Impact factor: 6.741