Giulio Maltoni1, Maximiliano Zioutas2, Marta Mosticchio2, Lorenzo Iughetti3, Barbara Predieri3, Patrizia Bruzzi3, Brunella Iovane4, Pietro Lazzeroni4, Vanna Graziani5, Tosca Suprani6, Sara Monti6, Maria E Street7, Anna Lasagni7, Francesca De Luca8, Francesca Libertucci9, Benedetta Mainetti10, Sara Riboni11, Paola Sogno Valin12, Andrea Pession2, Stefano Zucchini2. 1. Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, via Massarenti 11, 40138, Bologna, Italy. giulio.maltoni@aosp.bo.it. 2. Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, via Massarenti 11, 40138, Bologna, Italy. 3. Pediatric Unit, Department of Medical and SurgicalSciences of the Mothers, Children and Adults, University of Modena and Reggio Emilia, 41124, Modena, Italy. 4. Center for Diabetes in Children and Adolescents, Department of Woman and Child Health, Parma University Hospital, Parma, Italy. 5. Department of Pediatrics, Santa Maria Delle Croci Hospital, Ravenna, Italy. 6. Department of Pediatrics, Bufalini Hospital, Cesena, Italy. 7. Division of Pediatric Endocrinology and Diabetology Pediatrics, Department of Mother and Child, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy. 8. Pediatrics Unit, Azienda Ospedaliero-Universitaria di Ferrara, 44124, Ferrara, Italy. 9. Pediatrics Unit, AUSL Romagna, 47921, Rimini, Italy. 10. Pediatrics Unit, Ospedale "G.B. Morgagni - L. Pierantoni", Forlì, Italy. 11. Department of Pediatrics and Neonatology, Guglielmo da Saliceto Hospital, Cantone del Cristo 50, Piacenza, Italy. 12. Department of Pediatrics, Santa Maria Della Scaletta Hospital, Imola, Italy.
Abstract
In the last few decades, many studies have reported an increasing global incidence of type 1 diabetes. Studies on migrant populations have underlined the importance of both environmental and genetic factors. AIMS: Evaluate the incidence of type 1 diabetes in North African vs Italian children aged 0-14 years from 1 January 2015, to 31st December 2018, in Emilia-Romagna region, Italy. METHODS: Clinical and epidemiological data about childhood onset type 1 diabetes in Emilia Romagna region were retrospectively collected by the regional centers of pediatric diabetology and matched using 3 different data sources. RESULTS: 365 new cases were diagnosed. Total cumulative incidence was 15.4/100,000/year. North African cases showed a cumulative incidence of 53.8/100,000/year, statistically significant compared to cumulative incidence of the Italian cases alone 13.1/100,000/year (p value < 0.001). The annual incidence did not differ in the 4 years for both groups. Conclusion: The incidence of type 1 diabetes in the pediatric age (0 14 years) was significantly higher in the North African population than in the Italian one, suggesting that a mix of genetic and environmental factors may have caused the increase in newly diagnosed cases. WHAT IS KNOWN: • The incidence of type 1 diabetes largely varies worldwide. • Study on immigrants helped to better understand the interplay role between genetics and environment. WHAT IS NEW: • This is the first study focused on the incidence of children and adolescents of North African migrants in Italy. • The incidence of children and adolescents of North African migrants in Emilia Romagna region, Italy, seems to be higher than that reported in the host countries, and, above all, than that reported in highest-incidence countries in Europe and in the world.
In the last few decades, many studies have reported an increasing global incidence of type 1 diabetes. Studies on migrant populations have underlined the importance of both environmental and genetic factors. AIMS: Evaluate the incidence of type 1 diabetes in North African vs Italian children aged 0-14 years from 1 January 2015, to 31st December 2018, in Emilia-Romagna region, Italy. METHODS: Clinical and epidemiological data about childhood onset type 1 diabetes in Emilia Romagna region were retrospectively collected by the regional centers of pediatric diabetology and matched using 3 different data sources. RESULTS: 365 new cases were diagnosed. Total cumulative incidence was 15.4/100,000/year. North African cases showed a cumulative incidence of 53.8/100,000/year, statistically significant compared to cumulative incidence of the Italian cases alone 13.1/100,000/year (p value < 0.001). The annual incidence did not differ in the 4 years for both groups. Conclusion: The incidence of type 1 diabetes in the pediatric age (0 14 years) was significantly higher in the North African population than in the Italian one, suggesting that a mix of genetic and environmental factors may have caused the increase in newly diagnosed cases. WHAT IS KNOWN: • The incidence of type 1 diabetes largely varies worldwide. • Study on immigrants helped to better understand the interplay role between genetics and environment. WHAT IS NEW: • This is the first study focused on the incidence of children and adolescents of North African migrants in Italy. • The incidence of children and adolescents of North African migrants in Emilia Romagna region, Italy, seems to be higher than that reported in the host countries, and, above all, than that reported in highest-incidence countries in Europe and in the world.
Authors: Joseph I Wolfsdorf; Nicole Glaser; Michael Agus; Maria Fritsch; Ragnar Hanas; Arleta Rewers; Mark A Sperling; Ethel Codner Journal: Pediatr Diabetes Date: 2018-10 Impact factor: 4.866
Authors: Patrizia Banin; Fiorenza Rimondi; Aldo De Togni; Stefano Cantoni; Giovanni Chiari; Lorenzo Iughetti; Silvana Salardi; Stefano Zucchini; Alberto Marsciani; Tosca Suprani; Luis Tarchini; Anna Tozzola; Rossella Xella; Maria Marsella; Vincenzo De Sanctis Journal: Acta Biomed Date: 2010-12
Authors: A Zung; M Elizur; N Weintrob; T Bistritzer; A Hanukoglu; Z Zadik; M Phillip; K Miller; I Koren; C Brautbar; S Israel Journal: Hum Immunol Date: 2004-12 Impact factor: 2.850