| Literature DB >> 35027728 |
Chansavath Phetsouphanh1, David R Darley2, Anthony D Kelleher3,4, Gail V Matthews5,6, Daniel B Wilson7, Annett Howe8, C Mee Ling Munier8, Sheila K Patel9, Jennifer A Juno10, Louise M Burrell9, Stephen J Kent10,11, Gregory J Dore8,2.
Abstract
A proportion of patients surviving acute coronavirus disease 2019 (COVID-19) infection develop post-acute COVID syndrome (long COVID (LC)) lasting longer than 12 weeks. Here, we studied individuals with LC compared to age- and gender-matched recovered individuals without LC, unexposed donors and individuals infected with other coronaviruses. Patients with LC had highly activated innate immune cells, lacked naive T and B cells and showed elevated expression of type I IFN (IFN-β) and type III IFN (IFN-λ1) that remained persistently high at 8 months after infection. Using a log-linear classification model, we defined an optimal set of analytes that had the strongest association with LC among the 28 analytes measured. Combinations of the inflammatory mediators IFN-β, PTX3, IFN-γ, IFN-λ2/3 and IL-6 associated with LC with 78.5-81.6% accuracy. This work defines immunological parameters associated with LC and suggests future opportunities for prevention and treatment.Entities:
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Year: 2022 PMID： 35027728 DOI： 10.1038/s41590-021-01113-x
Source DB: PubMed Journal: Nat Immunol ISSN： 1529-2908 Impact factor: 31.250