Literature DB >> 35023131

Developing Treatments for Alzheimer's and Related Disorders with Precision Medicine: A Vision.

Dimitrios Avramopoulos1, Dimitrios Kapogiannis2,3, Jeannie-Marie Leoutsakos4, Constantine G Lyketsos5, Vasiliki Mahairaki2, Milap Nowrangi4, Kenichi Oishi6, Esther S Oh7, Paul B Rosenberg4, Quincy Samus4, Gwenn S Smith4, Kenneth Witwer8, Sevil Yasar7, Peter P Zandi4.   

Abstract

Precision medicine, also known as personalized medicine, is concerned with finding the right treatment for the right patient at the right time. It is a way of thinking focused on parsing heterogeneity ultimately down to the level of the individual. Its main mission is to identify characteristics of heterogeneous clinical conditions so as to target tailored therapies to individuals. Precision Medicine however is not an agnostic collection of all manner of clinical, genetic and other biologic data in select cohorts. This is an important point. Simply collecting as much information as possible on individuals without applying this way of thinking should not be considered Precision Medicine.
© 2021. The Author(s), under exclusive license to Springer Nature Switzerland AG.

Entities:  

Keywords:  Alzheimer’s; Precision medicine treatments

Mesh:

Year:  2021        PMID: 35023131      PMCID: PMC9358929          DOI: 10.1007/978-3-030-78787-5_49

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN: 0065-2598            Impact factor:   3.650


  8 in total

1.  Concordance between the assessment of Aβ42, T-tau, and P-T181-tau in peripheral blood neuronal-derived exosomes and cerebrospinal fluid.

Authors:  Longfei Jia; Qiongqiong Qiu; Heng Zhang; Lan Chu; Yifeng Du; Jiewen Zhang; Chunkui Zhou; Furu Liang; Shengliang Shi; Shan Wang; Wei Qin; Qi Wang; Fangyu Li; Qigeng Wang; Yan Li; Luxi Shen; Yiping Wei; Jianping Jia
Journal:  Alzheimers Dement       Date:  2019-08       Impact factor: 21.566

2.  A Precision Medicine Model for Targeted NSAID Therapy in Alzheimer's Disease.

Authors:  Sid E O'Bryant; Fan Zhang; Leigh A Johnson; James Hall; Melissa Edwards; Paula Grammas; Esther Oh; Constantine G Lyketsos; Robert A Rissman
Journal:  J Alzheimers Dis       Date:  2018       Impact factor: 4.472

3.  A multidimensional home-based care coordination intervention for elders with memory disorders: the maximizing independence at home (MIND) pilot randomized trial.

Authors:  Quincy M Samus; Deirdre Johnston; Betty S Black; Edward Hess; Christopher Lyman; Amrita Vavilikolanu; Jane Pollutra; Jeannie-Marie Leoutsakos; Laura N Gitlin; Peter V Rabins; Constantine G Lyketsos
Journal:  Am J Geriatr Psychiatry       Date:  2014-01-04       Impact factor: 4.105

Review 4.  Dementia prevention, intervention, and care.

Authors:  Gill Livingston; Andrew Sommerlad; Vasiliki Orgeta; Sergi G Costafreda; Jonathan Huntley; David Ames; Clive Ballard; Sube Banerjee; Alistair Burns; Jiska Cohen-Mansfield; Claudia Cooper; Nick Fox; Laura N Gitlin; Robert Howard; Helen C Kales; Eric B Larson; Karen Ritchie; Kenneth Rockwood; Elizabeth L Sampson; Quincy Samus; Lon S Schneider; Geir Selbæk; Linda Teri; Naaheed Mukadam
Journal:  Lancet       Date:  2017-07-20       Impact factor: 202.731

5.  Time course of neuropsychiatric symptoms and cognitive diagnosis in National Alzheimer's Coordinating Centers volunteers.

Authors:  Elizabeth A Wise; Paul B Rosenberg; Constantine G Lyketsos; Jeannie-Marie Leoutsakos
Journal:  Alzheimers Dement (Amst)       Date:  2019-04-18

Review 6.  The new genetic landscape of Alzheimer's disease: from amyloid cascade to genetically driven synaptic failure hypothesis?

Authors:  Pierre Dourlen; Devrim Kilinc; Nicolas Malmanche; Julien Chapuis; Jean-Charles Lambert
Journal:  Acta Neuropathol       Date:  2019-04-13       Impact factor: 17.088

7.  Effect of reductions in amyloid levels on cognitive change in randomized trials: instrumental variable meta-analysis.

Authors:  Sarah F Ackley; Scott C Zimmerman; Willa D Brenowitz; Eric J Tchetgen Tchetgen; Audra L Gold; Jennifer J Manly; Elizabeth Rose Mayeda; Teresa J Filshtein; Melinda C Power; Fanny M Elahi; Adam M Brickman; M Maria Glymour
Journal:  BMJ       Date:  2021-02-25

8.  Abnormal CSF amyloid-β42 and tau levels in hip fracture patients without dementia.

Authors:  Esther S Oh; Kaj Blennow; George E Bigelow; Sharon K Inouye; Edward R Marcantonio; Karin J Neufeld; Paul B Rosenberg; Juan C Troncoso; Nae-Yuh Wang; Henrik Zetterberg; Frederick E Sieber; Constantine G Lyketsos
Journal:  PLoS One       Date:  2018-09-25       Impact factor: 3.240

  8 in total

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