The Development of Antisense RNA Treatments Using Engineered Protein Substrates.

Current efforts to design supercharged protein assemblies have opened the door for the creation of substrates that could be used for drug delivery and as substrates for antiviral delivery mechanisms. We explore the potential for antiviral delivery with antisense RNAs that bind their phosphate backbone to the charge of an engineered protein oligomer, providing structural integrity to the RNA strand and adding possible steric effects to prevent reaction with unintended targets.