Rossybelle P Amorrortu1, Yayi Zhao1, Neil A Fenske2, Basil S Cherpelis2, Jane L Messina3,4, Anna R Giuliano5, Vernon K Sondak4, Michael J Schell6, Sandrine Mckay-Chopin7, Tarik Gheit7, Tim Waterboer8, Massimo Tommasino7, Dana E Rollison1. 1. Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA. 2. Department of Dermatology and Cutaneous Surgery, University of South Florida College of Medicine, Tampa, Florida, USA. 3. Department of Anatomic Pathology, Moffitt Cancer Center, Tampa, Florida, USA. 4. Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, Florida, USA. 5. Center for Immunization and Infection Research in Cancer, Moffitt Cancer Center, Tampa, Florida, USA. 6. Biostatistics and Bioinformatics Shared Resource, Moffitt Cancer Center, Tampa, Florida, USA. 7. International Agency for Research on Cancer, World Health Organization, Lyon, France. 8. Infections and Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
Abstract
BACKGROUND: Cutaneous human papillomaviruses (cuHPV) and polyomaviruses (HPyV) have been implicated in skin cancers; however, interpretation of findings across studies is complicated by limited understanding of the natural history of these infections across normal tissue types. METHODS: In total, 675 eyebrow hair (EBH) and skin swab (SSW) samples were collected from 71 skin cancer screening patients every 6 months over 2 years and measured for presence of β-HPV, γ-HPV, and HPyV. Incidence, persistence, and clearance of cuHPV/HPyV were estimated, and risk factors associated with infection were examined. RESULTS: Prevalence, incidence, and persistence of β-HPV, γ-HPV, and HPyV were consistently higher in SSW than in EBH, with types 5, 24, 49, 76 and Merkel cell polyomavirus (MCPyV) having incidence rates greater than 20 per 1000 person-months. Prevalent γ-HPV EBH infections persisted more often in women (P = .024), incident β-HPV EBH infections persisted less often among individuals with history of blistering sunburn (P = .019), and prevalent MCPyV SSW infections persisted more often in those with a history of skin cancer (P = .033). CONCLUSIONS: Incidence and persistence of cuHPV/HPyV were observed in SSW and EBH; however, none of the risk factors examined were commonly associated with cuHPV/HPyV infections across normal tissue types.
BACKGROUND: Cutaneous human papillomaviruses (cuHPV) and polyomaviruses (HPyV) have been implicated in skin cancers; however, interpretation of findings across studies is complicated by limited understanding of the natural history of these infections across normal tissue types. METHODS: In total, 675 eyebrow hair (EBH) and skin swab (SSW) samples were collected from 71 skin cancer screening patients every 6 months over 2 years and measured for presence of β-HPV, γ-HPV, and HPyV. Incidence, persistence, and clearance of cuHPV/HPyV were estimated, and risk factors associated with infection were examined. RESULTS: Prevalence, incidence, and persistence of β-HPV, γ-HPV, and HPyV were consistently higher in SSW than in EBH, with types 5, 24, 49, 76 and Merkel cell polyomavirus (MCPyV) having incidence rates greater than 20 per 1000 person-months. Prevalent γ-HPV EBH infections persisted more often in women (P = .024), incident β-HPV EBH infections persisted less often among individuals with history of blistering sunburn (P = .019), and prevalent MCPyV SSW infections persisted more often in those with a history of skin cancer (P = .033). CONCLUSIONS: Incidence and persistence of cuHPV/HPyV were observed in SSW and EBH; however, none of the risk factors examined were commonly associated with cuHPV/HPyV infections across normal tissue types.
Authors: Margaret R Karagas; Heather H Nelson; Peter Sehr; Tim Waterboer; Therese A Stukel; Angeline Andrew; Adele C Green; Jan Nico Bouwes Bavinck; Ann Perry; Steven Spencer; Judy R Rees; Leila A Mott; Michael Pawlita Journal: J Natl Cancer Inst Date: 2006-03-15 Impact factor: 13.506
Authors: Linda Struijk; Jan Nico Bouwes Bavinck; Patrick Wanningen; Els van der Meijden; Rudi G J Westendorp; Jan Ter Schegget; Mariet C W Feltkamp Journal: J Invest Dermatol Date: 2003-12 Impact factor: 8.551
Authors: Amy M Dworkin; Stephanie Y Tseng; Dawn C Allain; O Hans Iwenofu; Sara B Peters; Amanda E Toland Journal: J Invest Dermatol Date: 2009-06-25 Impact factor: 8.551
Authors: Yayi Zhao; Rossybelle P Amorrortu; Neil A Fenske; Basil Cherpelis; Jane L Messina; Vernon K Sondak; Anna R Giuliano; Michael J Schell; Tim Waterboer; Michael Pawlita; Sandrine McKay-Chopin; Tarik Gheit; Massimo Tommasino; Dana E Rollison Journal: Int J Cancer Date: 2020-09-07 Impact factor: 7.396