Manganese Oxide Nanoclusters for Skin Photoprotection.

An ultraviolet (UV) filter is the core component of sunscreen and protects skin from various photo damages. Current UV filters are hampered by skin penetration, poor photostability, photocatalytic generation of harmful reactive oxygen species (ROS), and potential environmental risks. In this work, manganese dioxide nanoclusters were developed as an eco-friendly UV filter by a facile two-step synthesis, using colloid silica as support under ambient conditions. These nanoclusters show a better UV-shielding profile than commercial titanium dioxide nanoparticles and capability to scavenge various ROS. They can be easily incorporated by a sunscreen formula and demonstrate an excellent skin photoprotection performance both in vitro and in vivo.