Literature DB >> 3502127

Identification of a flunixin metabolite in the horse by gas chromatography-mass spectrometry.

P Jaussaud1, D Courtot, J L Guyot, J Paris.   

Abstract

The main metabolite of flunixin, a hydroxylated product, has been identified by gas chromatography-mass spectrometry and 1H NMR spectroscopy in equine urine and plasma. The method also permits the qualitative monitoring of the urinary elimination of the drug and its metabolite. The two products are detected up to 175 and 54 h, respectively, after a single intravenous administration at the dose of 1 mg/kg. Simultaneous detection of the two compounds increases the reliability of anti-doping control analysis.

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Year:  1987        PMID: 3502127     DOI: 10.1016/0378-4347(87)80334-1

Source DB:  PubMed          Journal:  J Chromatogr


  2 in total

1.  Voltammetric Determination of Flunixin on Molecularly Imprinted Polypyrrole Modified Glassy Carbon Electrode.

Authors:  Abd-Elgawad Radi; Nadia Abd El-Ghany; Tarek Wahdan
Journal:  J Anal Methods Chem       Date:  2016-05-08       Impact factor: 2.193

2.  Identification and characterization of the enzymes responsible for the metabolism of the non-steroidal anti-inflammatory drugs, flunixin meglumine and phenylbutazone, in horses.

Authors:  Heather K Knych; Carrie J Finno; Russell Baden; Rick M Arthur; Daniel S McKemie
Journal:  J Vet Pharmacol Ther       Date:  2020-08-05       Impact factor: 1.786

  2 in total

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