Henry Lai1, Emine O Bayman2, Michael O Bishop3, Richard Landis4, Steven E Harte5, Quentin Clemens6, Larissa V Rodriguez7, Siobhan Sutcliffe8, Bayley J Taple9, Bruce D Naliboff10. 1. Departments of Surgery (Urology) and Anesthesiology, Washington University School of Medicine, St Louis, MO. Electronic address: laih@wustl.edu. 2. Department of Biostatistics, University of Iowa, Iowa City, IA; Department of Anesthesiology, University of Iowa, Iowa City, IA. 3. Department of Biostatistics, University of Iowa, Iowa City, IA. 4. Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. 5. Chronic Pain and Fatigue Research Center, Department of Anesthesiology, University of Michigan, Ann Arbor, MI. 6. Department of Urology, University of Michigan, Ann Arbor, MI. 7. Departments of Urology, and Obstetrics and Gynecology, University of Southern California, Los Angeles, CA. 8. Departments of Surgery (Public Health Sciences), Washington University School of Medicine, St Louis, MO. 9. Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL. 10. Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Abstract
OBJECTIVE: To examine how often urologic chronic pelvic pain syndrome (UCPPS) patients progressed from Pelvic Pain Only at baseline to Widespread Pain, or vice versa, during 1-year longitudinal follow-up. METHODS: Men and women with UCPPS enrolled in the MAPP-I Epidemiology and Phenotyping Study completed a self-report body map to indicate their locations of pain every 2 months over 12 months. Patients were categorized at each assessment into one of three pain phenotypes: (1) Pelvic Pain Only, (2) an Intermediate group, (3) Widespread Pain. Only patients who completed 3 or more follow-ups were included in this longitudinal analysis. The primary outcome measure was pain classification at the majority (≥60%) of follow-up assessments. Longitudinal trends of somatic symptom burden were also assessed. RESULTS: Among the 93 UCPPS participants with Pelvic Pain Only at baseline, only 2% (n = 2) showed a Widespread Pain phenotype for the majority of assessments over 12 months. Among the 121 participants who had Widespread Pain at baseline, 6% (n = 7) demonstrated Pelvic Pain Only for the majority of assessments over 12 months. Over half of participants (≥53%) stayed in their baseline phenotypic group. Somatic symptom burden remained stable over 12 months for each of the groups with high intra-class correlation coefficient (0.67 to 0.82). CONCLUSION: It was uncommon for UCPPS patients to progress from Pelvic Pain Only to Widespread Pain, or vice versa, over 12 months. These data suggest that Pelvic Pain Only and Widespread Pain are distinct UCPPS phenotypes that are relatively stable over 12 months of follow up.
OBJECTIVE: To examine how often urologic chronic pelvic pain syndrome (UCPPS) patients progressed from Pelvic Pain Only at baseline to Widespread Pain, or vice versa, during 1-year longitudinal follow-up. METHODS: Men and women with UCPPS enrolled in the MAPP-I Epidemiology and Phenotyping Study completed a self-report body map to indicate their locations of pain every 2 months over 12 months. Patients were categorized at each assessment into one of three pain phenotypes: (1) Pelvic Pain Only, (2) an Intermediate group, (3) Widespread Pain. Only patients who completed 3 or more follow-ups were included in this longitudinal analysis. The primary outcome measure was pain classification at the majority (≥60%) of follow-up assessments. Longitudinal trends of somatic symptom burden were also assessed. RESULTS: Among the 93 UCPPS participants with Pelvic Pain Only at baseline, only 2% (n = 2) showed a Widespread Pain phenotype for the majority of assessments over 12 months. Among the 121 participants who had Widespread Pain at baseline, 6% (n = 7) demonstrated Pelvic Pain Only for the majority of assessments over 12 months. Over half of participants (≥53%) stayed in their baseline phenotypic group. Somatic symptom burden remained stable over 12 months for each of the groups with high intra-class correlation coefficient (0.67 to 0.82). CONCLUSION: It was uncommon for UCPPS patients to progress from Pelvic Pain Only to Widespread Pain, or vice versa, over 12 months. These data suggest that Pelvic Pain Only and Widespread Pain are distinct UCPPS phenotypes that are relatively stable over 12 months of follow up.
Authors: H Henry Lai; Thomas Jemielita; Siobhan Sutcliffe; Catherine S Bradley; Bruce Naliboff; David A Williams; Robert W Gereau; Karl Kreder; J Quentin Clemens; Larissa V Rodriguez; John N Krieger; John T Farrar; Nancy Robinson; J Richard Landis Journal: J Urol Date: 2017-03-31 Impact factor: 7.450
Authors: J Curtis Nickel; Dean A Tripp; Michel Pontari; Robert Moldwin; Robert Mayer; Lesley K Carr; Ragi Doggweiler; Claire C Yang; Nagendra Mishra; Jorgen Nordling Journal: J Urol Date: 2010-08-17 Impact factor: 7.450
Authors: Larissa V Rodríguez; Alisa J Stephens; J Quentin Clemens; Dedra Buchwald; Claire Yang; Henry H Lai; John N Krieger; Craig Newcomb; Cate S Bradley; Bruce Naliboff Journal: Urology Date: 2018-11-16 Impact factor: 2.649
Authors: H Henry Lai; Carol S North; Gerald L Andriole; Lori Cupps; David Song; Timothy J Ness; Barry A Hong Journal: J Urol Date: 2013-12-19 Impact factor: 7.450
Authors: J Richard Landis; David A Williams; M Scott Lucia; Daniel J Clauw; Bruce D Naliboff; Nancy A Robinson; Adrie van Bokhoven; Siobhan Sutcliffe; Anthony J Schaeffer; Larissa V Rodriguez; Emeran A Mayer; H Henry Lai; John N Krieger; Karl J Kreder; Niloofar Afari; Gerald L Andriole; Catherine S Bradley; James W Griffith; David J Klumpp; Barry A Hong; Susan K Lutgendorf; Dedra Buchwald; Claire C Yang; Sean Mackey; Michel A Pontari; Philip Hanno; John W Kusek; Chris Mullins; J Quentin Clemens Journal: BMC Urol Date: 2014-08-01 Impact factor: 2.264