Literature DB >> 35018803

Short Communication: Population Representation in HIV Cure Research: A Review of Diversity Within HIV Cure Studies Based in the United States.

Carly Roberts1, Emma Creamer2, Cheriko A Boone3, A Toni Young2, Manya Magnus1.   

Abstract

HIV is experienced across diverse populations, with gender and racial/ethnic minority populations bearing a significant proportion of disease. With National Institutes of Health (NIH) placing a priority on the enrollment of women and racial/ethnic minorities into studies, it is important to understand the diversity of participants in research. We sought to characterize how HIV cure research studies report data on diversity. A sampling frame of publications with funding provided by the Martin Delaney Collaboratories for HIV Research in 2019 was reviewed for reporting of demographic data. Of 55 publications that included research on humans/human specimens, only 51% provided any demographic description. There often is insufficient consideration of diversity of populations in HIV cure research. Ameliorating gaps in this regard will require recruitment of diverse populations/specimens and specifications to report demographic data in articles. This will ensure inclusion of diverse participants in HIV cure research from earliest laboratory to eventual phase III studies.

Entities:  

Keywords:  HIV cure research; diversity; generalizability; representativeness

Mesh:

Year:  2022        PMID: 35018803      PMCID: PMC9464046          DOI: 10.1089/AID.2021.0127

Source DB:  PubMed          Journal:  AIDS Res Hum Retroviruses        ISSN: 0889-2229            Impact factor:   1.723


  9 in total

Review 1.  Sex, age, race and intervention type in clinical studies of HIV cure: a systematic review.

Authors:  Rowena E Johnston; Mary M Heitzeg
Journal:  AIDS Res Hum Retroviruses       Date:  2015-01       Impact factor: 2.205

2.  Estimating the Prevalence of HIV and Sexual Behaviors Among the US Transgender Population: A Systematic Review and Meta-Analysis, 2006-2017.

Authors:  Jeffrey S Becasen; Christa L Denard; Mary M Mullins; Darrel H Higa; Theresa Ann Sipe
Journal:  Am J Public Health       Date:  2018-11-29       Impact factor: 9.308

3.  African ancestry influences CCR5 -2459G>A genotype-associated virologic success of highly active antiretroviral therapy.

Authors:  Vinay K Cheruvu; Robert P Igo; Richard J Jurevic; David Serre; Peter A Zimmerman; Benigno Rodriguez; Rajeev K Mehlotra
Journal:  J Acquir Immune Defic Syndr       Date:  2014-05-01       Impact factor: 3.731

4.  A landscape analysis of HIV cure-related clinical research in 2019.

Authors:  Liz Barr; Richard Jefferys
Journal:  J Virus Erad       Date:  2020-09-02

5.  Race/Ethnicity and Protease Inhibitor Use Influence Plasma Tenofovir Exposure in Adults Living with HIV-1 in AIDS Clinical Trials Group Study A5202.

Authors:  Cindy J Bednasz; Charles S Venuto; Qing Ma; Eric S Daar; Paul E Sax; Margaret A Fischl; Ann C Collier; Kimberly Y Smith; Camlin Tierney; Edward P Acosta; Donald E Mager; Gene D Morse
Journal:  Antimicrob Agents Chemother       Date:  2019-03-27       Impact factor: 5.191

6.  Considerations for Increasing Racial, Ethnic, Gender, and Sexual Diversity in HIV Cure-Related Research with Analytical Treatment Interruptions: A Qualitative Inquiry.

Authors:  Karine Dubé; John Kanazawa; Chadwick Campbell; Cheriko A Boone; Allysha C Maragh-Bass; Danielle M Campbell; Moisés Agosto-Rosario; Jamila K Stockman; Dázon Dixon Diallo; Tonia Poteat; Mallory Johnson; Parya Saberi; John A Sauceda
Journal:  AIDS Res Hum Retroviruses       Date:  2021-05-31       Impact factor: 2.205

7.  Safety, tolerability, and pharmacokinetics of long-acting injectable cabotegravir in low-risk HIV-uninfected individuals: HPTN 077, a phase 2a randomized controlled trial.

Authors:  Raphael J Landovitz; Sue Li; Beatriz Grinsztejn; Halima Dawood; Albert Y Liu; Manya Magnus; Mina C Hosseinipour; Ravindre Panchia; Leslie Cottle; Gordon Chau; Paul Richardson; Mark A Marzinke; Craig W Hendrix; Susan H Eshleman; Yinfeng Zhang; Elizabeth Tolley; Jeremy Sugarman; Ryan Kofron; Adeola Adeyeye; David Burns; Alex R Rinehart; David Margolis; William R Spreen; Myron S Cohen; Marybeth McCauley; Joseph J Eron
Journal:  PLoS Med       Date:  2018-11-08       Impact factor: 11.069

Review 8.  A Systematic Review of the Inclusion (or Exclusion) of Women in HIV Research: From Clinical Studies of Antiretrovirals and Vaccines to Cure Strategies.

Authors:  Mirjam J Curno; Samuela Rossi; Ioannis Hodges-Mameletzis; Rowena Johnston; Matt A Price; Shirin Heidari
Journal:  J Acquir Immune Defic Syndr       Date:  2016-02-01       Impact factor: 3.731

9.  A landscape analysis of HIV cure-related clinical trials and observational studies in 2018.

Authors:  Liz Barr; Richard Jefferys
Journal:  J Virus Erad       Date:  2019-11-04
  9 in total
  1 in total

1.  Perceptions of Risks and Benefits of Participating in HIV Cure-Related Research Among Diverse Young Adults Living with HIV in the United States: Qualitative Research Findings.

Authors:  Parya Saberi; Chadwick K Campbell; John A Sauceda; Samuel Ndukwe; Karine Dubé
Journal:  AIDS Res Hum Retroviruses       Date:  2022-06-28       Impact factor: 1.723

  1 in total

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