Nonrandomized Comparison of Efficacy and Side Effects of Bicalutamide Compared With Luteinizing Hormone-Releasing Hormone (LHRH) Analogs in Combination With Radiation Therapy in the CHHiP Trial.

PURPOSE: CHHiP is a randomized trial evaluating moderately hypofractionated radiation therapy for treatment of localized prostate cancer. Of all participants, 97% of them had concurrent short-course hormone therapy (HT), either luteinizing hormone-releasing hormone analog (LHRHa) or 150 mg of bicalutamide daily. This exploratory analysis compares efficacy and side effects in a nonrandomized comparison. METHODS AND MATERIALS: In our study, 2700 patients received LHRHa and 403 received bicalutamide. The primary endpoint was biochemical/clinical failure. Groups were compared with Cox regression adjusted for various prognostic factors and stratified by radiation therapy dose. A key secondary endpoint was erectile dysfunction (ED) assessed by clinicians (using scores from Late Effects on Normal Tissues: Subjective/Objective/Management [LENT-SOM] subjective erectile function for vaginal penetration) and patients (single items within the University of California-Los Angeles Prostate Cancer Index [UCLA PCI] and Expanded Prostate Cancer Index Composite [EPIC]-50 questionnaires) at 2 years and compared between HT regimens by χ2 trend test.
RESULTS: Bicalutamide patients were significantly younger (median 67 vs 69 years LHRHa). Median follow-up was 9.3 years. There was no difference in biochemical or clinical failure with an adjusted hazard ratio or 0.97 (95% confidence interval, 0.77-1.23; P = .8). At 2 years, grade ≥2 LENT-SOM ED was reported in significantly more LHRHa patients (313 out of 590; 53%) versus bicalutamide (17 out of 68; 25%) (P < .0001). There were no differences in ED seen with UCLA-PCI and EPIC-50 questionnaires.
CONCLUSIONS: In this nonrandomized comparison, there was no evidence of a difference in efficacy according to type of HT received. Bicalutamide preserved clinician assessed (LENT-SOM) erectile function at 2 years but patient-reported outcomes were similar between groups.

Introduction

Neoadjuvant or adjuvant hormone therapy (HT) given with radiation therapy improves both biochemical progression-free survival and overall survival for men with localized prostate cancer.1, 2, 3 Most trials have used luteinizing hormone-releasing hormone analogs (LHRHa) to achieve this effect. Bicalutamide is an oral nonsteroidal antiandrogen which acts as a competitive antagonist at the androgen receptor. Bicalutamide is sometimes preferred to LHRHa due to perceived reduced cardiovascular risk or the patient's wish to preserve sexual function.

In the metastatic disease setting, bicalutamide results in inferior overall and progression-free survival compared with LHRHa although there is a suggestion that side effects might be reduced., However for patients with nonmetastatic disease, older studies showed no difference in overall survival or clinical progression in those receiving antiandrogens versus LHRH or orchidectomy., In the salvage radiation therapy setting, bicalutamide has been shown to reduce overall mortality.

To the best of our knowledge, there are no large randomized studies which have compared bicalutamide with LHRHa combined with radiation therapy. It is not known whether bicalutamide has equivalent efficacy to LHRHa and whether it preserves sexual function after curative radiation therapy.

The CHHiP trial is a multicenter, randomized, phase 3, noninferiority trial comparing 2 Gy per fraction (74 Gy in 37 fractions) with 3 Gy per fraction (either 60 Gy in 20 fractions or 57 Gy in 19 fractions) in men with localized prostate cancer. The trial showed noninferiority of 60 Gy in 20 fractions compared with 74 Gy in 37 fractions. The trial protocol permitted bicalutamide monotherapy or LHRHa. In these exploratory analyses, we compare the efficacy, clinician-reported, and patient-reported outcomes (PRO) of men receiving bicalutamide with those receiving LHRHa.

Materials and Methods

Trial design

The CHHiP trial design has been described elsewhere. Briefly, men with histologically proven, T1b-T3a N0M0 prostate cancer with a maximum Gleason score of 7 were eligible. Men were randomized (1:1:1) to receive 74 Gy in 37 fractions over 7.4 weeks or 60 Gy in 20 fractions over 4 weeks or 57 Gy in 19 fractions over 3.8 weeks. Randomization was stratified by National Comprehensive Cancer Network risk classification and treatment center. HT was nonrandomized. The trial was registered (ISRCTN97182923), approved by the London Multicenter Research Ethics Committee (04/MRE02/10), and conducted in accordance with principles of good clinical practice.

Procedures

We mandated HT in men with National Comprehensive Cancer Network intermediate and high-risk disease. HT was given in monthly depot injections of LHRH agonists with initial cyproterone acetate to prevent “flare” phenomenon, or alternatively 150 mg of bicalutamide was given daily if preferred by the patient and physician. The duration of HT was at least 3 months (maximum 6 months) before start of radiation therapy and continued until the end of radiation therapy. The last monthly depot injection was to be given within 1 week of the start or during radiation therapy. Bicalutamide was continued for 2 months after the end of radiation therapy to mimic the duration of action of monthly depot LHRHa injections.

PSA concentrations were recorded pre-HT and preradiation therapy; then at weeks 10, 18, and 26 after start of radiation therapy; and then at intervals of 6 months for 5 years thereafter annually. We assessed acute and late toxicity using clinician-reported outcome grading systems and PRO questionnaires. We conducted sexual function assessments pre-HT; pre-radiation therapy; and then at 6, 12, 18, 24, 36, 48, and 60 months, and graded the assessments according to the Late Effects on Normal Tissues: Subjective/Objective/Management (LENT-SOM) and the Royal Marsden (RMH) scoring systems. Men participating in a PRO substudy received questionnaires at baseline if they had not yet started androgen deprivation therapy (ADT), and all men received questionnaires preradiation therapy and at 10 weeks and 6, 12, 18, and 24 months after the start of radiation therapy thereafter annually until 5 years. Full details of the PRO substudy have been published previously. Initially, we used the University of California-Los Angeles Prostate Cancer Index, including Short Form 36 and Functional Assessment of Cancer Therapy-Prostate, but after a protocol amendment in 2009, we used the Expanded Prostate Cancer Index Composite (EPIC), and Short Form 12 instead. We used the Radiation Therapy Oncology Group (RTOG) system to score late bladder and bowel toxicity.

Outcomes

Efficacy was the primary endpoint, which we evaluated as biochemical or clinical failure (BCF) and overall survival. We used the Phoenix consensus definition of a prostate-specific antigen concentration > nadir + 2ng/mL to define biochemical failure; clinical failure events included recommencement of HT, local recurrence, lymph node, or pelvic recurrence and distant metastases. Key secondary endpoints for this analysis were the proportion of patients with LENT-SOM grade ≥2 erectile dysfunction (ED) for vaginal penetration at 2 years; we assessed erectile functioning over time by clinician-assessed LENT-SOM and RMH scales (Appendix E1); individual patient-reported sexual functioning scores (UCLA PCI/EPIC questionnaire); general quality of life measures including hot flushes, fatigue, breast tenderness, low mood, and general health scores; testosterone levels pre-HT and at 12 months; and RTOG bladder and bowel toxicity. We report disease-free survival and recommencement of hormone therapy as exploratory endpoints.

Statistical considerations

All analyses presented are exploratory in nature, but a statistical analysis plan was written before conducting the analyses. Because this was a nonrandomized comparison of LHRHa with bicalutamide, we made statistical comparisons for the baseline demographic data by HT group (t tests, Mann-Whitney, χ2 tests and χ2 trend tests were used as appropriate). We used Kaplan-Meier methods to analyze time-to-event data stratified by treatment regimen. We compared HT groups using the log-rank test. An adjusted Cox model included age (continuous), National Comprehensive Cancer Network risk group (low vs intermediate v high), Gleason score (≤6 vs 7 & 8), clinical T-stage (T1 vs T2 vs T3a), prehormone prostate-specific antigen concentration (<10 vs 10-20 vs >20 ng/mL), and the proportion of core biopsies that were positive (≤50 vs >50%).21, 22, 23 We used stratified log-rank tests to compare HT groups for baseline variables that were imbalanced. The proportional hazards assumption held for all time-to-event analyses. Hazard ratios (HR) less than 1 favored bicalutamide. We conducted competing risks analysis for BCF with death from any cause as the competing event.

We restricted analysis for the sexual functioning secondary endpoints to patients with preserved sexual function pre-HT. For the RMH scale, we analyzed data separately for patients with normal erections (grade 0) and decreased erections (grade 1) pre-HT. We used χ2 trend tests to compare hormone groups at 2 years. Due to the nonrandomized comparisons being made, we used multivariable logistic models for analysis of some secondary endpoints. We created binary variables for grade ≥2 (poor/very poor for PRO endpoints) at 2 years and adjusted models for age, pre-HT symptom score, and pre-HT testosterone level.

To account for multiple testing, we used a significance level of .5% for the primary endpoints of efficacy and key secondary endpoints (LENT-SOM erectile function for vaginal penetration and UCLA/EPIC question on ability to have an erection). For all other secondary endpoints, we used a significance level of .1%. We based analyses on a data snapshot taken on October 9, 2019, for the efficacy and clinician assessments (median follow-up 9.3; interquartile range [IQR], 8.2-11.0 years) and on August 26, 2018, for the PRO data (final data set, follow-up completed at 5 years for PRO). We undertook all analyses with STATA v15.1.

Results

Baseline demographics

Baseline demographics for patients in the LHRHa (n = 2700) and bicalutamide (n = 403) groups are shown in Table 1. All but 29 patients had started hormones before randomization. HT was omitted in 3% of men who are excluded from all analyses. Patients receiving bicalutamide were younger, with a median age of 67 years (IQR, 63-72) compared with 69 years (IQR, 65-73) for LHRHa. Men receiving bicalutamide had a shorter time between diagnosis and randomization and a lower burden of core involvement (see Table 1). Patients treated with LHRHa received HT for a median of 5.3 months (IQR, 4.5-6.2) (measured from date of first monthly injection to last injection plus 4 weeks) and bicalutamide patients for a median 6.3 months (IQR 5.7-7.1) months.

Table 1

Baseline Demographics by Hormone Therapy Received

Demographics	LHRHa (n = 2700)		Bicalutamide (n = 403)		P Value
	No.	%	No.	%
Treatment group
74Gy/37 fractions	881	33	144	36	.4*
60Gy/20 fractions	910	34	133	33
57Gy/19 fractions	909	33	126	31
NCCN risk group
High-risk	332	12	50	12	.4†
Intermediate risk	2006	74	308	76
Low Risk	362	13	45	11
Age (y)
Median (IQR)	69 (65-73)		67 (63-72)		<.001‡
Range	44-85		50-83
Age category
≤69 y	1445 (54)		256 (64)		<.001*
≥70 y	1255 (46)		147 (36)
Gleason score
≤6	918	34	114	28	.04†
3 + 4	1179	44	189	47
4 + 3	515	19	89	22
8	87	3	11	3
Clinical T stage
T1	945	35	158	39	0.4§
T2	1520	56	203	50
T3	232	9	42	11
TX	1	<1	0	0
MRI T stage
T1	158	8	51	16	.044§
T2	1235	66	184	59
T3	445	24	75	24
TX	44	2	4	1
Months from histologic confirmation of prostate cancer to randomization					<.001‡
N	2697		403
Median (IQR)	5 (3-6)		4 (3-5)
Range	0-177		1-102
Prehormone PSA (ng/mL)
N	2676		401		.8‡
Median (IQR)	10.3 (7.2, 14.6)		10.0 (7.2, 14.6)
Range	0.2, 33.6		1.3, 28.8
Number of core biopsies taken‖, ¶
N	2006		261		.3‡
Median (IQR)	11 (10-12)		11 (8-13)
Range	2-20		3-20
Number of positive core biopsies‖
N	1892		247		<.001‡
Median (IQR)	4 (3-7)		4 (2-6)
Range	0-16		0-12
Proportion of positive core biopsies‖
N	1862		234		.001*
<50%	973 (52)		150 (64)
≥50%	889 (48)		84 (36)
Maximum length of core involvement (%)
N	1426		259		.001‡
Median (IQR)	40 (16-70)		30 (10-60)
Range	1-100		1-100
Maximum length of core involvement¶ (mm)
N	383		79		<.001‡
Median (IQR)	10 (5-16)		6 (3-9)
Range	0.4-20		0.7-20

Abbreviations: IQR = interquartile range; MRI = magnetic resonance imaging; NCCN = National Comprehensive Cancer Network; PSA = prostate-specific antigen.

χ2.

Test for trend.

Mann-Whitney.

Test for trend excluding TX.

Number of core biopsies taken/positive was capped at 20 as part of central data cleaning with values >20 discarded as errors/implausible in an era when template biopsies were not used.

Maximum length of core involvement capped at 20 mm as part of central data cleaning with values >20 discarded as errors/implausible given cutting length of biopsy needle.

Efficacy

There was no evidence of a difference in BCF between the 2 HT groups with an unadjusted HR 0.97 (95% CI, 0.77-1.23, P = .8) (Fig. 1A). In the LHRHa group, the 5 year BCF-free rate was 88% (95% CI, 87-89) and 86% (95% CI, 82-89) in the bicalutamide group. In view of the imbalances in baseline characteristics we performed log-rank tests stratified for age (≤69 v >69) and proportion of positive core biopsies (≤50 v >50%). These indicated no difference between HT groups for BCF. The adjusted HR was 0.98 (95% confidence interval [CI], 0.70-1.36; P = .9) (Appendix E2). Competing risks analysis indicated no evidence of a difference between HT groups (Gray's test P = .9) (Appendix E3). An exploratory analysis restricted to unfavorable intermediate and high-risk patients (as defined by Zumsteg et al) gave similar results (Appendix E4). There was no evidence of a difference in overall survival between HT groups with an adjusted HR of 0.87 (95% CI, 0.60-1.26; P = .5). (Fig. 1B). Time to recommencement of hormone therapy and disease free survival also showed no evidence of a difference between the HT groups (Figs. 1C and 1D; also see Appendix E2).

Fig. 1

Kaplan-Meier curves for (A) biochemical and/or clinical failure, (B) overall survival, (C) recommencing hormone treatment, and (D) disease free survival by hormone therapy received.

Clinician-reported sexual functioning (LENT-SOM and RMH)

Before starting HT, 607 out of 786 patients (77%) receiving LHRHa and 73 out of 89 patients (82%) receiving bicalutamide had preserved erectile function (LENT-SOM grade ≤2) and were included in subsequent analyses (Appendix E5). At 2 years, grade ≥2 LENT-SOM ED (intermittently insufficient for vaginal penetration or worse) was reported in significantly more LHRHa patients (313 out of 590; 53%) compared with 17 out of 68 patients (25%) receiving bicalutamide patients (P <.0001). At 2 years, grade 3 to 4 ED (erections insufficient for penetration or impotent) was reported in 220 out of 585 patients (38%) receiving LHRHa and 14 out of 68 patients (21%) receiving bicalutamide. A similar pattern was seen throughout follow-up with fewer bicalutamide patients assessed as having severe symptoms according to the LENT-SOM sexual dysfunction scale (Figs. 2A-D). A multivariable logistic model including pre-HT erectile function score, age and pre-HT testosterone level also indicated reduced erectile dysfunction in the bicalutamide patients (odds ratio, 0.30; 99 % CI, 0.10-0.90; P = .005) (Appendix E6).

Fig. 2

LENTSOM sexual dysfunction items: distribution of grade at each time point assessed by hormone therapy received. (A) Subjective: erectile function for vaginal penetration. (B) Subjective worse grade. (C) Objective worse grade. (D) Management worse grade. Abbreviations: PH = prehormones; PR = preradiation therapy.

Using the RMH scale prehormones, 378 out of 761 patients (50%) and 44 out of 80 patients (55%) reported normal erections in the LHRHa and bicalutamide groups, respectively; and 259 out of 761 patients (34%) and 23 out of 80 patients (29%) reported decreased erections in the LHRHa and bicalutamide groups, respectively (Appendix E5). Of those with preserved sexual function at baseline, a lower proportion of the patients receiving bicalutamide developed ED defined using the RMH scale, but this did not reach statistical significance. At 2 years, there was no evidence of a difference between HT groups for either patients with normal erections (P = .1) or decreased erections (P = .6) prehormones (Appendix E7).

Patient-reported sexual functioning (UCLA-PCI)

Before starting hormones, 215 out of 553 patients (39%) and 17 out of 49 patients (34%) of LHRHa and bicalutamide patients reported very poor or poor ability to have an erection (see Appendix E5). At 2 years, there was no evidence of a difference between HT groups for ability to have an erection (P > .9). Multivariable models also indicate no difference between hormone treatments (odds ratio, 0.77; 99% CI, 0.15-3.85; P = .676) (Appendix E8). Patients reported worst erectile function at 10 weeks from the start of radiation therapy (Fig. 3A). UCLA/EPIC sexual function scores appeared better in bicalutamide patients before starting radiation therapy and at the week 10 and month 6 assessments (no statistical comparisons made). From 12 months onwards the distribution of scores remained similar for each HT group (Appendix E9). This pattern was also seen when all patients were included in the analysis, including those without erectile function documented prehormonal therapy (Appendix E10).

Fig. 3

Patient-reported outcomes of sexual function assessed using the University of California Los Angeles Prostate Cancer Index and Expanded Prostate Cancer Index Composite questionnaires—distribution of grade at each time point assessed by hormone therapy received. (A) Rate your ability to have an erection. (B) Usual quality of erections. (C) Rate your ability to function sexually. (D) How big a problem has sexual function been (sexual bother). Abbreviations: PH = prehormones; PR = preradiation therapy.

Patient-reported general items

Hot flushes were worse in the LHRHa group up to 6 months, but untroublesome thereafter (Fig. 4A) with no difference between HT groups at 2 years (P = .4). Lack of energy was reported similarly between HT groups, and there was little improvement in scores over time (Fig. 4B), with no evidence of difference at 2 years (P = .3). Breast tenderness was reported more often in patients receiving bicalutamide across all time points assessed (Fig. 4C). At week 10, moderate or worse breast tenderness was seen in 10 out of 39 patients (26%) on bicalutamide and 6 out of 214 patients (2.8%) on LHRHa. More bicalutamide patients (3 out of 40; 7.5%) remained with moderate or big problems with breast tenderness at 2 years than the LHRHa group (2 out of 299; 0.7%) (P = .002). General health assessments were similar in the HT groups over time (Fig. 4D) with no difference at 2 years (P = .5). Reported levels of depression were low, and there was no difference between HT groups at 2 years (P = .6) (Appendix E11).

Fig. 4

Patient-reported outcomes of general quality of life items—distribution of scores at each time point assessed by hormone therapy received (A) Hot flushes, (B) Lack of energy (C) Breast tenderness (D) General health score. Abbreviations: PH = prehormones; PR = preradiation therapy.

Before starting HT, there was no difference in the testosterone levels between patients receiving LHRHa or bicalutamide with median values of 12.6 and 11.9 nmol/L respectively (P >.9) (Fig. 5 and Appendix E12). By 12 months, the majority of patients who received LHRHa (1170 out of 1553; 75%) had testosterone levels within the normal range (>8 nmol/L), as did 181 out of 213 (85%) of bicalutamide patients (Appendix E12).

Fig. 5

Boxplots illustrating testosterone levels at baseline and 12 months.

Late RTOG bladder toxicity was reported by very few patients, with similar distributions for those receiving LHRHa or bicalutamide (Appendix E13). Small numbers of patients had predominantly grade 1 RTOG bowel toxicity, which was similar for both HT groups (see Appendix E13).

Discussion

This nonrandomized comparison of short course bicalutamide and LHRHa with prostate radiation therapy showed similar efficacy with a median follow-up over 8 years. Initially, sexual function declined less preradiation therapy using bicalutamide with some evidence of reduced ED 2 years after treatment. Hot flushes were reduced using bicalutamide. Gynaecomastia and breast discomfort were more common in the bicalutamide group (25.6% at 6 months) but less marked that in other studies which have reported rates of about 70%, likely due to the protocol recommendation to use tamoxifen if gynaecomastia developed and the shorter course of bicalutamide. Prophylactic use of Tamoxifen may be more effective. By 12 months, testosterone levels had recovered in most patients in both groups but there was no difference in levels of ongoing fatigue. Interventions using structured exercise might be of value.,

HT using LHRHa with radiation therapy is well established for the treatment of localized prostate cancer.,,, Bicalutamide has compared favorably with placebo in locally advanced and recurrent disease,, but no phase 3 comparisons with LHRHa have been performed. Single-center series,, albeit with short follow-up, have reported similar efficacy between bicalutamide and LHRHa. However, concerns about the efficacy of bicalutamide monotherapy have persisted. One randomized trial did not show the expected improvement in biochemical control with bicalutamide compared with radiation therapy alone, and, for earlier disease, overall survival with bicalutamide appeared to be worse than watchful waiting in another study.

Because bicalutamide is less effective in metastatic disease,, standard practice is to offer LHRHa concomitantly with radiation therapy, and our data does not change that. There is some concern relating to cardiovascular side effects with LHRHa and a suggestion that antiandrogens may have a more favorable profile, although this remains controversial, and higher cardiac events were noted in the bicalutamide arm of the RTOG 9601 study. For men wishing to minimize the chance of erectile dysfunction, our analysis suggests that bicalutamide is a safe option but any advantages are modest.

Long-term ED benefit for bicalutamide was apparent using the LENT-SOM assessment but not with the RMH scoring system nor the PRO. We speculate that this might be because patients selecting bicalutamide had higher expectations of retaining sexual function and were consequently more bothered by ED. With both HT options, ED remains a major concern; a combination of radiation therapy and increasing age appear responsible. It has been suggested that dose to the penile bulb may be important. The use of image guided radiation therapy facilitates small margins, sparing these structures in most patients. In addition, prehabilitation or early treatment with PDE5 after radiation therapy may be beneficial.

Limitations of our work are that it is a nonrandomized comparison, albeit from a large phase 3 trial. Only 13 % of the patient population had HT with bicalutamide. In consequence, there are imbalances in some presenting features; bicalutamide-treated patients were younger, with some more favorable pathologic parameters, although adjusted analyses continued to show similar efficacy between groups. Most patients had started HT before collection of baseline data and randomization (Appendix E14), limiting the number of patients with both baseline and 2-year data for comparison. However, when data for all patients was analyzed (see Appendix E10) similar patterns were seen. Additionally, PRO data collection decreased over time limiting the robustness of data interrogation.

We acknowledge the problems inherent with nonrandomized data, but our analysis should reassure oncologists considering prescribing short-course bicalutamide with radiation therapy and assist appropriate discussion with patients. Bicalutamide may be preferred in patients wishing to maintain sexual function, although the evidence presented here shows no guarantee of avoiding ED. Bicalutamide may also be preferred in patients who experience significant hot flushes, especially if this limits compliance with LHRHa, although this may be achieved at the cost of some breast symptoms, unless prophylactic tamoxifen is given.

Conclusion

In a nonrandomized analysis within the CHHiP trial, patients receiving HT with bicalutamide had similar 5-year BCF compared with those receiving LHRHa. There was some evidence that bicalutamide reduced ED, although this was not seen on all outcome scales. Bicalutamide also reduced hot flushes but global quality of life was unaffected. With appropriate patient counseling about risks and benefits, Bicalutamide can be considered as an option for men wishing to preserve sexual function or for those who have severe hot flushes.