Literature DB >> 3501321

Differential selectivity of endothelium-derived relaxing factor and nitric oxide in smooth muscle.

K Shikano1, E H Ohlstein, B A Berkowitz.   

Abstract

The selectivity of endothelium-derived relaxing factor (EDRF) and nitric oxide (NO) on smooth muscle relaxation was examined and compared. EDRF released from was examined and compared. EDRF released from bovine pulmonary arterial endothelium (BPAE) in culture and NO were superfused over vascular, tracheal, gastrointestinal and uterine smooth muscle. EDRF relaxed vascular smooth muscle but not tracheal, gastrointestinal or uterine smooth muscle. NO relaxed vascular and gastrointestinal smooth muscle but not tracheal or uterine smooth muscle. There was a differential selectivity between the relaxant effect of EDRF and NO on smooth muscle.

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Year:  1987        PMID： 3501321      PMCID： PMC1853672          DOI： 10.1111/j.1476-5381.1987.tb11347.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  5 in total

1.  Mechanism of action of some inhibitors of endothelium-derived relaxing factor.

Authors:  S Moncada; R M Palmer; R J Gryglewski
Journal:  Proc Natl Acad Sci U S A       Date:  1986-12       Impact factor: 11.205

2.  Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor.

Authors:  R J Gryglewski; R M Palmer; S Moncada
Journal:  Nature       Date:  1986 Apr 3-9       Impact factor: 49.962

3.  Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor.

Authors:  G M Rubanyi; P M Vanhoutte
Journal:  Am J Physiol       Date:  1986-05

4.  The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine.

Authors:  R F Furchgott; J V Zawadzki
Journal:  Nature       Date:  1980-11-27       Impact factor: 49.962

5.  Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor.

Authors:  R M Palmer; A G Ferrige; S Moncada
Journal:  Nature       Date:  1987 Jun 11-17       Impact factor: 49.962
  5 in total
  24 in total

1.  Mechanisms of gastroprotection by transdermal nitroglycerin in the rat.

Authors:  S Calatayud; M J Sanz; A Canet; R Bello; F D de Rojas; J V Esplugues
Journal:  Br J Pharmacol       Date:  1999-07       Impact factor: 8.739

2.  Comparison of relaxation responses of vascular and non-vascular smooth muscle to endothelium-derived relaxing factor (EDRF), acidified sodium nitrite (NO) and sodium nitroprusside.

Authors:  T M Cocks; J A Angus
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-04       Impact factor: 3.000

Review 3.  Vascular endothelium in ischemic heart disease: possible role for endothelium-derived relaxing factor.

Authors:  A H Henderson
Journal:  Cardiovasc Drugs Ther       Date:  1989-06       Impact factor: 3.727

4.  Co-axial bioassay of a smooth muscle relaxant factor released from guinea-pig tracheal epithelium.

Authors:  L B Fernandes; J W Paterson; R G Goldie
Journal:  Br J Pharmacol       Date:  1989-01       Impact factor: 8.739

5.  Influence of haemoglobin and erythrocytes on the effects of EDRF, a smooth muscle inhibitory factor, and nitric oxide on vascular and non-vascular smooth muscle.

Authors:  J S Gillespie; H Sheng
Journal:  Br J Pharmacol       Date:  1988-12       Impact factor: 8.739

6.  S-nitrosothiols as vasodilators: implications regarding tolerance to nitric oxide-containing vasodilators.

Authors:  P J Henry; O H Drummer; J D Horowitz
Journal:  Br J Pharmacol       Date:  1989-11       Impact factor: 8.739

7.  The role of the L-arginine-nitric oxide pathway in relaxation of the opossum lower oesophageal sphincter.

Authors:  A Tøttrup; M A Knudsen; H Gregersen
Journal:  Br J Pharmacol       Date:  1991-09       Impact factor: 8.739

8.  Bioassay of nitric oxide released upon stimulation of non-adrenergic non-cholinergic nerves in the canine ileocolonic junction.

Authors:  G E Boeckxstaens; P A Pelckmans; I F Ruytjens; H Bult; J G De Man; A G Herman; Y M Van Maercke
Journal:  Br J Pharmacol       Date:  1991-05       Impact factor: 8.739

9.  Role of NO in vagally-mediated relaxations of guinea-pig stomach.

Authors:  A L Meulemans; L F Helsen; J A Schuurkes
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-02       Impact factor: 3.000

10.  Oral N(G)-nitro-L-arginine in conscious dogs: 24 hour hypertensive response in relation to plasma levels.

Authors:  S Huber; J G Grohs; S Schwarzacher; G Raberger
Journal:  Amino Acids       Date:  1992-10       Impact factor: 3.520
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